Ascertaining ROHs with a single genome assembly using PLINK

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Emily Dziedzic

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Feb 13, 2026, 10:00:29 PMFeb 13
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I've completed a chromosome-level genome assembly of a single individual—there is no available data from other individuals from this species at this time—and I'm wondering if it would be possible to determine ROHs using PLINK with just this individual assembly?

I don't know if using data from closely related species would be helpful... I'm honestly not sure where to start, so any advice would be much appreciated.

Cheers,
Emily
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