IBS/IBD calculation in Plink for haploid organisms

142 views
Skip to first unread message

Masih

unread,
Feb 6, 2019, 9:13:01 PM2/6/19
to plink2-users
I am trying to run plink GWAS for a non-human haploid organism which has shown to have significant population structure. To correct for this structure, I want to use plink IBS clustering but plink automatically eliminates all non-autosomal chromosome from this analysis resulting in error. 

I was wondering why Plink removes haploid chromosome data for calculation of IBS ( This is not explained in the official webpage of plink) and if I just rename chromosome name to human chromosome 1 and run the IBS analysis, would the results be reliable for stratification correction?
Thanks

Christopher Chang

unread,
Feb 6, 2019, 9:15:42 PM2/6/19
to plink2-users
You'd have to interpret the raw numbers a bit differently than usual, but yes, it is reasonable to make plink think the data is diploid just for the purpose of calculating the IBS matrix.
Reply all
Reply to author
Forward
0 new messages