Features that have been added in the last four months include:
- General linear/logistic regression with permutation (--linear/--logistic). (This is slow, but should not be unusably so.)
- Fast complete linkage clustering (--cluster).
- Classical multidimensional scaling (--mds-plot), with a list of eigenvalues if desired.
-
Run-of-homozygosity analysis (--homozyg). Pools of overlapping runs
can also be analyzed (this is where the main speedups are).
- Support for arbitrary chromosome names (--allow-extra-chr).
As before, bugfixes will go into the stable 0.22.x builds, while new features will go into the 0.23+ development branch.
The
next major stable build announcement, scheduled for early 2014, is
planned to be a PLINK 1.50 release candidate. It will include most
remaining PLINK flags which have not been rendered obsolete by more
accurate free software, including CNV analysis commands and multimarker
tests. (After discussing the issue with someone who actually spent some
time trying to optimize MaCH, though, I have decided to just drop
imputation for now.) It will also add support for arbitrarily long
allele names (which have actually been supported by PLINK this whole
time).
The #1 priority after that point will be adding support
for non-biallelic markers and phased data. (This will be
time-consuming.)
I will be in Boston for the ASHG 2013 meeting next week; you are welcome to talk to me there.