On C#, the profiler shows the entire call stack as well, including the native calls - which is really great compared to AIR.
The GC system for C# and PlayScript are shared, so when you plug memory profiling in, it will be for both. Also the profiler will work for pure C# projects so you could potentially use it without PlayScript. The code that implements telementry is written in C#, and could be extracted to a library that did not depend on any AS/PlayScript code.