Nanozoomer Download
Autumn Pitz
HALO AP is a case-centric digital pathology platform that is deployed worldwide and has transformed the way pathologists and researchers analyze, manage, and utilize digital pathology images through its comprehensive suite of tools and features for efficient and accurate image evaluation, management, and collaboration. HALO AP and Hamamatsu NanoZoomer Slide scanners are already in use together at a variety of institutions and centers in the US for research purposes, and in the EU and the UK for clinical applications. In the US, Indica Labs will continue to offer HALO AP for Research Use Only applications, and will now also offer HALO AP Dx for primary diagnosis of surgical pathology slides prepared from FFPE tissue.
The NanoZoomer S360MD Slide scanner system is an expertly crafted digital pathology solution that displays images and provides image management tools and aids qualified pathologists in the review and interpretation of digital images of surgical pathology slides prepared from FFPE tissue.
1HALO AP Dx (K232833) is FDA-cleared for primary diagnostic use with the Hamamatsu NanoZoomer S360MD Slide scanner in the US. In addition, HALO AP Dx provides built-in compliance and certifications with FDA 21 CFR Part 11 and HIPAA.
HALO AP is CE-IVDR marked for in-vitro diagnostic use in Europe, the UK, and Switzerland. HALO AP is For Research Use Only in the US and is not FDA cleared for clinical diagnostic use. In addition, HALO AP provides built-in compliance and certifications with FDA 21 CFR Part 11, HIPAA, and GDPR.
Hamamatsu Photonics K.K. is a global leader in the design and manufacturing of photonics devices, including advanced imaging detectors for medical, environmental, biological, and semi-conductor industries. Building on over 60 years of engineering experience, our NanoZoomer line of digital scanners has been a trailblazer in whole slide imaging scanner technology for pathology research and clinical diagnostics with 510(k) cleared NanoZoomer S360MD Slide scanner system. Renowned for excellent image quality, reliability, and interoperability, the NanoZoomer line has been at the forefront of digital pathology for over two decades. For more information we welcome you to visit www.nanozoomer.com.
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Laser light of specific wavelengths is scanned across the sample and filtered before detection to produce a high resolution image composed of a small optical slice of the sample. Deconvolution further enhances resolution.
Laser light of specific wavelengths is scanned across the sample and filtered before detection to produce a high resolution image composed of a small optical slice of the sample. STED enahances resolution by shrinking fluorescence to a small spot with a depletion laser. Deconvolution further enhances resolution, including STED images.
Fluorescent light from lasers filtered for emission produce an image from wide-field resolutions to super resolutions down to 60nm XY. A lattice pattern is placed in the light path to surpass the diffraction limit and produce super resolutions in lattice SIM. A lattice pattern is placed in the light path to improve resolutions over wide-field.
Serial block face scanning electron microscopy generates EM resolution 3D images. The system has an ultramicrotome inside the chamber of the SEM, which allows for automatic cutting of a tissue block. The surface of the block is imaged by detection of back-scattered electrons and then a thin section (30-50nm) is cut from the block face. The sample block is then imaged again and a sequence of images can be compiled automatically.
Laser light of specific wavelengths is passed through the sample as a sheet from 1 or 2 sides, perpendicular to the detection optics. Laser excitation, Emission filters and 2 CMOS cameras generate an image at a specific wavelength. Sample is moved through the sheet of light for Z stack acquisition.
Laser light of specific wavelengths is scanned across the sample and filtered before detection to produce a high resolution image composed of a small optical slice of the sample. Alternative detection at high resolution and sensitivity avoids discrimination of light with a pinhole, and utliizes a 32 detector array that can generate higher resolution images by detection of specific airy units.
The Hamamatsu Nanozoomer is an older system. Therefore we no longer perform training sessions on this microscope. Our new Olympus VS200 slide scanner is the replacement system for the nanozoomer. Please request training on the Olympus VS200 slide scanner if you want access to slide scanning technology.
Deconvolution with image correction featuring constrained iterative 3D image restoration and image correction, a quantitatively validated deconvolution solution generating the most accurate measure of sample fluorescence available.
If you want us to do fluorescence scans, you MUST circle the tissue section that you exposure times set from. It should be the first slide in the set. Circle the section in sharpie on the back of the slide, not the coverslip.
If you wish to do any live cell imaging in the core, you must have approval by submitting a BUA authorization form to core staff along with a copy of your BUA report listing the proposed research material.
Drug-Gene Interaction Database (DGIdb)
Helps investigators annotate genes of interest with respect to known drug-gene interactions and potential druggability. Developed at The McDonnell Genome Institute at Washington University School of Medicine.
DGIdb database
Gynecologic Oncology Tissue Bank (GOTB)
Provides human biological specimens to support cancer research, as well as lab support for clinical trials and academic research.
GOTB information
Siteman Cancer Center Tissue Procurement Core (TPC)
Assists cancer researchers in the collection, storage, quality assurance and scientific utilization/impact of biospecimens collected from cancer patients and study participants, in order to better understand the molecular and genomic basis of cancer.
TPC information
Tissue Histology Core
Includes a slate of microtome, cryostats, embedding center, oven, tissue processor, microscope, hood, chemical cabinets, a nanozoomer microscope, H&E staining station, and a full time histology technician. Also has full capacity to process and analyze human and mouse tissues.
Tissue Histology Core information
Women and Infants Health Specimen Consortium (WISHC)
Pools resources across patient clinics to provide researchers unique access to pregnancy-related biospecimens and data collected over months and even years of care. In addition to providing banked samples, WIHSC can fulfill custom specimen requests.
WIHSC website