Profact Construct Srl

[Brayan Jacobsen]

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Background: Validity is the ability of an instrument to measure what it claims to measure. It means the degree to which the empirical evidence supports the trustworthiness of interpretations based on the calculated scores. The hematological malignancy (HM) specific patient reported outcome measure (HM-PRO), is a newly developed instrument for use in daily clinical practice as well as in research. This study, provides the evidence for construct validity of the HM-PRO, specifically focusing on the convergent and divergent validity compared to the other established instruments used in hematology.

Methods: This validation study adopted a prospective cross-sectional design where a heterogeneous group of patients diagnosed with different HMs and different disease state were recruited. A total of 905 patients were recruited from seven secondary care hospitals in the UK and online through five patient organizations. Patients were asked to complete the HM-PRO and other cancer specific PRO's, FACT-G and EORTC QLQ C-30. Data analysis was performed using IBM SPSS 23 statistical software.

Conclusion: The construct validity evidence presented in this research is a testimony to the HM-PRO's ability to measure HRQoL issues which it intends to measure. This is of utmost importance when a PRO is used in routine clinical practice so that the interpretation of the scores or response to an individual item is understood by the clinicians/nurses as intended by the patients.

Harnage, who has been at Old Dominion for 21 of the last 32 years, will retire at the end of June. He developed a reputation as the University's master builder, overseeing construction of 17 buildings - from the Virginia Beach Center in 1999 to the Education Building this year.

"I believe in spending a lot of time on buildings - how do the materials work together, how does it fit into the campus, the shape of the buildings, the glass you use, the finishes inside the building.... All of these ingredients go together to make a successful building."

Old Dominion's president, John R. Broderick, said: "David was the heart, soul and architect for the way our campus looks today. His vision is one of the reasons why students elected to come here in record numbers and why faculty and staff appreciate our home-away-from-home feel."

Deb Swiecinski, the associate vice president for financial services, has worked for or with Harnage for almost two decades. "It sometimes seems that he has a rough exterior," she said, "but deep down he cares about people and will extend himself in any way to help them."

That includes visiting employees in the hospital and attending funerals of their relatives. "He does little random acts of kindness without seeking attention for them," said Earl Nance, the university counsel.

He's more eager to discuss the five Old Dominion presidents, from Joseph Marchello to Broderick, for whom he's worked - and learned. "The day I walked onto this campus," Harnage said, "I was given the opportunity to work on interesting, complicated, important tasks by people who showed a lot of trust and care for me."

Broderick noted that Harnage wasn't just the building guy: "His leadership in technology development, strategic planning and budgeting will remain key ingredients to ODU's success long after he has retired."

In Broderick's campus email announcing Harnage's retirement, he wrote: "He arranged one of the best deals in Old Dominion's history many years ago, when he secured a $7 million IBM supercomputer - for free."

10. Human civilizations have harnessed wind power for thousands of years. Early forms of windmills used wind to crush grain or pump water. Now, modern wind turbines use the wind to create electricity. Learn how a wind turbine works.

6. Many of the components of wind turbines installed in the United States are manufactured here, with more than 500 wind-related manufacturing facilities across the country. The U.S. wind industry currently employs more than 125,000 people, including 23,543 in manufacturing and 45,088 in construction.

5. Offshore wind represents a major opportunity to provide power to highly populated coastal cities. There are small projects installed off the coasts of Rhode Island and Virginia, and dozens of larger projects in the works. See what the Energy Department is doing to develop offshore wind in the United States.

3. The United States has installed over 144,000 megawatts of wind capacity, making it the largest renewable energy source in the United States. In 2022, the U.S. wind industry added over 8,500 MW of new capacity, representing $12 billion in investment.

1. Wind energy provides more than 20% of total electricity generation in 12 states, with more than 50% in Iowa and South Dakota, and more than 30% in Kansas, Oklahoma, North Dakota, New Mexico, and Nebraska. Overall, wind energy supplied more than 10% of total U.S. electricity generation in 2022.

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