Sure assuming the *.DSK file is a something like a SimH Disk container file, many tools exist in the wild for Unix, Windows and Macs:
SIMH supplies a number in the "extractors" sub-directory of "simtools". In particular, Tim Liitt's port of the vhd_util(1) will give you raw access to the sectors, and disk ods2(1) will allow you to manipulate the image as a VMS file system. Paul Koning has supplied flx(1), which manipulates RSTS images. There are other tools for other formats like magenetic and paper tapes for other systems.
The late 1970s USENIX distribution included rtpip(1), a Unix program to read and write RT-11 disks (warning: it is not very smart and assumes the disk is RT11 format if you run it as root on a UNIX format RK05—bad things happen, as some of us know from the old days). ISTR that these images can be used to talk to RSX and maybe DOS11.
At some point, I remember seeing a tool to read/write DOS-8 disks, but I don't have a copy or a pointer to offer you.
Jay Logue has an awesome set of tools using the user space file system support: FUSE for Linux and MacOS: https://github.com/jaylogue/retro-fuse which support UNIX v6, v7 and 2.9BSD filesystem formats.
With the release of the PiDP-10, tools for some of the TOPS-10, TOPS-20, and ITS are appearing, but I'll let you look for these on your own.
If you do an Internet search, there are also tools for CP/M and MS-DOS that run on Unix systems at a minimum and will manipulate floppy images as well as real disks. I would expect the same for old Mac file systems but I have yet to look (google is your friend).
I would expect some of the other simulators, such as Hecurles for IBM, DTCyber for CDC, and the Multics simulator (which is a derivative of simh), to have similar tools, but I have not played with them, so I can not specifically say.