Hi Andy,
It is possible, and it's not horribly difficult. The problem is that I am half a world away from my PiDP-10 so I can't offer detailed instructions. There are only a few things that are important:
-- Create a directory at the same level as /opt/pidp10/systems/tops10-603/, calling it whatever you want
-- Put your .dsk image into that new directory. As well, copy the boot script files out of the /tops10-603/ directory into your directory. There are two, one for with PiDP-10 hardware and one for without
-- Edit the two boot script files to match your new configuration (e.g., system disk name(s)).
Part of the tricky-ness is that the SCANSW program does not necessarily recognize all switch configurations for booting. Well, at least it didn't a month or so ago. Oscar said he would modify it so that it did. If it's been modified then you're pretty well home free. There's a file, I think it's named "/opt/pidp10/systems/systems" or something like that. Edit that file to add in both your selected switch configuration and the name of your new directory. If everything is working then simply restarting the PiDP-10 with your selected switch configuration should start your version of TOPS-10.
If SCANSW has not been modified yet, then you may have to also do some editing in one of the other programs that is triggered in the boot process that translates the switch settings into the selected directory in /opt/pidp10/systems/. Sorry I can't provide more detail than this, but again I'm quite far from my PiDP-10. The code in that file is pretty easy to read and tweak. I had to hijack it because the switch setting group I wanted to use was pre-reserved for KL-10 and I needed KS-10 for my version of TOPS-10.
If you can get all of the details from someone else, great. If not, I will be back home around 10-July and can fill in all of the missing details then. So don't worry, it's possible without a lot of work, but you may have to wait a bit before you can make it all work on your PiDP-10.
Best,
-- steve