mapped KO ID not found on KEGG database

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Shuqi

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Jul 16, 2026, 1:19:40 PM (10 days ago) Jul 16
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Dear developers,

Thanks so much for developing such a wonderful tool!

I have a mapping/interpretation question related to the KO_metagenome_out: I have identified 12 KO functions with an KO ID, also successfully annotated with a description through the add_descriptions.py command, however when I went to search over on the KEGG database for a detailed map/network relationship with other enzymes, I happen to found there's no current KEGG page for these identifier. 

Here is the list of ID and their descriptions provided from picrust2-SC v2.6.2--
 feature description                                                            
   <chr>   <chr>                                                                  
 1 K01144  exodeoxyribonuclease V [EC:3.1.11.5]                                  
 2 K01263  cytosol alanyl aminopeptidase [EC:3.4.11.14]                          
 3 K02428  XTP/dITP diphosphohydrolase [EC:3.6.1.66]                              
 4 K03827  putative acetyltransferase [EC:2.3.1.-]                                
 5 K06421  small acid-soluble spore protein D (minor alpha/beta-type SASP)        
 6 K07239  heavy-metal exporter, HME family                                      
 7 K09469  2-aminoethylphosphonate-pyruvate transaminase                          
 8 K16291  L,D-transpeptidase ErfK/SrfK                                          
 9 K18707  threonylcarbamoyladenosine tRNA methylthiotransferase MtaB [EC:2.8.4.5]
10 K18821  lipoyl amidotransferase [EC:2.3.1.200]                                
11 K19234  L,D-transpeptidase YnhG                                                
12 K21394  TRAP-type transport system small permease protein                  

Using line10, K18821 as an example for my question, here is the webpage I could find having the K18821 pointed to "lipoyl amidotransferase" (https://www.kegg.jp/kegg-bin/get_htext#B11 ) however, if I go on click on the related hyperlink, the pop up window (https://www.kegg.jp/entry/K18821) shows 

Database: ORTHOLOGY
Entry: K18821
No such data was found.

Another example would be K03827 also shows "No such data was found." But I actually googled out publications discussed about it's annotation and its relatedness with human brain functions if it likely came from B.theta. citation: PMC12123878.

I guess I am mostly worried if I should be dropping these IDs out of my project or carry them on to go further with KO => KEGG pathway integration/interpretation. I would really appreciate your insights in this aspect. Thank you so much for your help.

Best Wishes,
Shuqi 
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