Dear developers,
Thanks so much for developing such a wonderful tool!
I have a mapping/interpretation question related to the KO_metagenome_out: I have identified 12 KO functions with an KO ID, also successfully annotated with a description through the add_descriptions.py command, however when I went to search over on the KEGG database for a detailed map/network relationship with other enzymes, I happen to found there's no current KEGG page for these identifier.
Here is the list of ID and their descriptions provided from picrust2-SC v2.6.2--
feature description
<chr> <chr>
1 K01144 exodeoxyribonuclease V [EC:3.1.11.5]
2 K01263 cytosol alanyl aminopeptidase [EC:3.4.11.14]
3 K02428 XTP/dITP diphosphohydrolase [EC:3.6.1.66]
4 K03827 putative acetyltransferase [EC:2.3.1.-]
5 K06421 small acid-soluble spore protein D (minor alpha/beta-type SASP)
6 K07239 heavy-metal exporter, HME family
7 K09469 2-aminoethylphosphonate-pyruvate transaminase
8 K16291 L,D-transpeptidase ErfK/SrfK
9 K18707 threonylcarbamoyladenosine tRNA methylthiotransferase MtaB [EC:2.8.4.5]
10 K18821 lipoyl amidotransferase [EC:2.3.1.200]
11 K19234 L,D-transpeptidase YnhG
12 K21394 TRAP-type transport system small permease protein
Database: ORTHOLOGY
Entry: K18821No such data was found.
Another example would be K03827 also shows "No such data was found." But I actually googled out publications discussed about it's annotation and its relatedness with human brain functions if it likely came from B.theta. citation: PMC12123878.
I guess I am mostly worried if I should be dropping these IDs out of my project or carry them on to go further with KO => KEGG pathway integration/interpretation. I would really appreciate your insights in this aspect. Thank you so much for your help.
Best Wishes,
Shuqi