mutation nsp14
Lynda Zeise
While investigating Ivermectin use in Japan, I came across information on a mutation which is fascinating.
Depending on the percentage of virus that has this mutation, it could cause the virus to disappear.
(And, as postulated, it could be why SARS-C0V mysteriously disappeared.)
Japan - Covid19 History, Ivermectin, and Mutation in nsp14
There are many contradictions surrounding information on SARS-Cov-2 and COVID-19. Since proper numbers are not being kept (e.g. OSHA not requiring reports of adverse vaccination reactions), it is difficult to analyze data and come to a conclusion on which one can base a prediction. One may find different numbers depending on the source and/or the date. Never-the-less, even working with incomplete information, some interesting details are worth consideration.
Here are numbers from Johns Hopkins Corona Virus Resource Center,
December 30,2021 - 28-Day Total:
Case-Fatality Ratio
Covid Cases Deaths. Incidence per 100,000 28 day Total Time
Japan 4,695 31 1,369 0.660% 1.06%
United States. 4,960,478. 39,563. 16,304 0.798% 1.53%
At the beginning of world infection, Japan was struggling, then, something happened which caused the total number of cases to dramatically drop. There are three events that are worth investigating: Levels of Vaccination, Dosing of Ivermectin, and (most interesting to me), Mutations in the virus possibly combined with unique DNA in the Japanese population.
Dr. John Campbell gives an interesting presentation of what could be happening in Japan. If you want to watch his presentation in full:
https://www.youtube.com/watch?v=E1GF0H9V_1g If you want a summary with a little more background information pulled together from several sources, you can read the following:
According to Akshay Narang, November 8, 2021 TFIGlobal, Japan:
Japan, a mask wearing country of 126 million people, has been traditionally averse to vaccines and is one of the more hesitant countries when it comes to trusting vaccine companies. Tokyo waited for two months before offering Pfizer/BioNTech to the public. Presently, Japan is more inclined towards acknowledging vaccine injuries and moving towards other treatment options, as compared to other developed nations. For example, Japan recommends the lowest number of vaccine shots to infants under one year of age. Japan also has the third-lowest infant mortality rate amongst all developed nations. (A reminder if you are not inclined to do statistics: Regression Analysis is a statistical method that allows one to examine the relationship between variables of interest as a way of sorting out if one variable has an impact on another.) A study of thirty-four developed nations reveals a definite pattern - lower infant mortality rates regressed against the number of vaccine doses given routinely in the nation. Japan’s medical infrastructure, therefore, works on a system that allows it to prevent excessive vaccination.
A history of COVID-19 infections per million people in Japan from Jan 2020 to Nov 2021.
Source: Johns Hopkins University, Seven Day Rolling Average,
Due to limited testing, the number of confirmed cases is lower
Than the number of infections.
In August of 2020, Coronavirus vaccination campaigns had not been widely introduced. As with other countries, Japan was struggling to tackle the Pandemic before it rolled out a vaccination campaign. In early January, it had recorded a total of more than 9,000 new infections; over a hundred deaths were recorded on February 4, 2021 as Japan faced pressure from other governments to roll out a vaccination campaign. With vaccination, the Coronavirus outbreak in Japan did get contained for some time, but by May 12, the infections started peaking again and over 7,000 new infections were recorded.
In August 2021, most of the people in Japan were inoculated, but still, the country recorded 22,301 new infections on August 22, 2021. The number of recorded COVID deaths in Japan in August 2021 were, on average, five times higher than those in August 2020.
The Peak Confirmed Cases Appears to be around August 22
Dr Haruo Ozaki, Chairman of the Tokyo Medical Association, published an
article in Japanese.
https://www.japantimes.co.ip/news/2021/11/22/national/japan-caronavirus-november22/
The doctor expresses frustration that, in spite of his official position and personal knowledge, his advice is not listened to. He states that in African countries where Ivermectin (a safe, inexpensive, and efficacious drug) is routinely used in the general population to prevent River Blindness, there is a low Coronavirus infection rate.
He feels that this is a well known fact that should be proved rigorous testing, but until that testing happens, the Japanese people should have access to Ivermectin to safely use at their own discretion. The following is a Google Translate summary of what Dr. Ozaki says:
“The situation is that the whole country is suffering from disasters. No one will listen to me so I will come up with a new policy.
The antiparasitic drug, Ivermectin, shows the number of infections and deaths of the new corona in a country that is prophylactically administered for another disease in Africa, but it seems that we are at the stage where it is Okay to have the patient give an informed outlet and get permission to use it.”
Here is a handy spot to give the history of River Blindness. Onchocerciasis, or river blindness, is a tropical disease caused by the parasitic worm Onchocerca volvulus. It is transmitted through repeated bites by blackflies of the genus Simulium. River Blindness was the second-leading infectious cause of blindness worldwide, according to the World Health Organization. Scientists William C. Campbell and Satoshi Ōmura shared the 2015 Nobel Prize for the discovery that Ivermectin could control River Blindness. Ivermectin works both preventively, through programs that spray river areas where the black flies breed, and as a treatment for people infected with the parasite. Ivermectin has been shown to work against several other parasitic diseases as well. See https://www.aoa.org/news/inside-optometry/aoa-news/river-blindness-treatment-receives-nobel-prize?sso=y
Ivermectin has been widely used in general African populations for 30 years to prevent River Blindness. Ivermectin kills the larvae and prevents them from causing damage but it does not kill the adults. The recommended treatment is Ivermectin, given every 6 months for the life span of the adult worms, 10-15 years. )
One can check Johns Hopkins Corona Virus Resource Center to confirm the numbers that many African countries which control River Blindness also have fewer deaths from COVID-19, but remember the old caveat “correlation does not necessarily imply causation”.
Now back to Dr.Ozaki. The problem is not necessarily that “no one will listen”, the problem is that countries sign agreements with the pharmaceutical companies which completely indemnify the company while putting the country at risk of paying for clearly wrongful doing by the company. Information security expert Ehden Biber had recently alleged, “If you were wondering why Ivermectin was suppressed, it is because the agreement that countries had with Pfizer does not allow them to escape their contract, which states that even if a drug will be found to treat COVID-19, the contract cannot be voided”.
A big stake for pharmaceutical companies amidst the ongoing Pandemic, is that a cheap treatment or a permanent cure for COVID-19 vaccines could end the need for multiple booster vaccine shots.
The pharmaceutical companies can “discourage” the use of cheap possible treatments, while in some cases, asking for additional indemnity from civil cases, meaning that the company would not be held liable for rare adverse effects or for its own acts of negligence, fraud or malice. The Bureau of Investigative Journalism reports Pfizer has been accused of “bullying” Latin American governments in Covid vaccine negotiations and has asked some countries to put up sovereign assets, such as embassy buildings and military bases, as a guarantee against the cost of any future legal cases,. https://www.thebureauinvestigates.com/stories/2021-02-23/held-to-ransom-pfizer-demands-governments-gamble-with-state-assets-to-secure-vaccine-deal
This includes those linked to company practices – say, if Pfizer sent the wrong vaccine or made errors during manufacturing. In comments featured in the Bureau of Investigative Journalism report, Georgetown Law professor Lawrence Gostin explained that “[s]ome liability protection is warranted, but certainly not for fraud, gross negligence, mismanagement, failure to follow good manufacturing practices.”
Here is a link to the Unredacted Pfizer contract with Dominican Republic, which shows broad indemnity provisions for COVID-19 vaccine sales (scroll down past the cover pages to page1 – the agreement is in English and Spanish):
https://www.keionline.org/misc-docs/Pfizer-DominicanRepublic-Vaccine-Term-Sheet-19Jan2021.pdf
The “Fact Checkers” point out that the Japanese Government has not endorsed Ivermectin. However, in August 2021, their Director in the FDA equivalent Governmental Ministry allowed its importation (e.g. from India) and doctors to prescribe it as needed regardless of the government’s official position. (Remember the contract with big Pharma.) Within two weeks the COVID-19 cases began to dramatically fall. See the peak of the graph.
About 2 weeks after allowing Ivermectin for treatment of COVID-19, the cases precipitously dropped. Interesting, but could something else have been partially, or uniquely responsible for the drop?
What else could have caused this precipitous drop in cases of COVID-19?
1. A more vaccinated population
2. Delta variant wave has ended in Japan with mutations in nsp14 which lead to “non-viability” ….( “non-viability” is Dr Campbell’s wording. I don’t like that word – I think “non-functional” is more accurate.)
3. Japanese genetics
Could the drop in cases be because of a more vaccinated population?
Japan, Canada, and UK vaccinated around 70% of their populations to US 60%. UK had more confirmed cases per million – possibly due to the US not having tests available. Canada, UK , and US have more reported deaths per million, while Japan deaths per million is approaching closer to zero. If Japan’s drop in death rate was due to vaccination alone, one could expect the shape of the graph to be similar for the other countries as they became more vaccinated. (The fact that Japan is an island nation may be important to spread, but not to death rate.)
The importance of nsp14:
The Delta wave has ended in Japan. Was that due to immunity in the population (natural immunity by having COVID-19 and immunity by vaccination) or was that due to what Dr. Campbell call “self-extinction” due to a genetic change in the virus itself?
Ituro Inoue, Professor at the National Institute of Genetics in Japan, postulates that the Delta variant in Japan accumulated too many mutations. Many viruses have a protein which checks for errors in copying the RNA code. If there is an error in creating the error-check protein, the error-check protein cannot do its job. If the error-check protein cannot do its job, other errors in the RNA copy cannot be corrected. If errors are not corrected, the virus becomes non-functional. (A review for newcomers to viruses – a virus does damage by taking over a cell nucleus and having the cell reproduce more viruses. The cell will be so busy making more viruses that the cell cannot do its job. Eventually the cell will have made so many copies of the virus, that the cell will burst and release all the newly made viruses into the body to enter more cells.) If the virus is stopped from entering the cell, the virus will be harmless. It will not be copied. The body will destroy the string of RNA and dispose of it.
In SARS-Cov-2, the virus that causes COVID-19, the mutation in the RNA virus error-correcting protein nsp14 is coded by a string of RNA nucleotides A394V. The majority of SARS-Cov-2 specimens in Japan have mutation A394V. This mutation has definitely occurred; the debate is over how much difference it is making.
Remember that SARS-CoV died off on its own. Could that have had something to do with an nsp14 protein mutation? There seems to be no specimen of SARS-CoV saved, so that is conjecture but if so, then the mutation in the nsp14 protein could be important to the decline of the virus.
Japanese Genetics
Japan is an island nation with very little interbreeding for centuries. People in Asia, especially Japanese, have a defense enzyme, APOBEC3A, that is not prominent in Europe and Africa. The protein (enzymes are proteins) APOBEC3A attacks RNA viruses. Could this have helped the drop in SARS-CoV-2 infections in Japan? Do Japanese immigrants to the US show less vulnerability to SARS-CoV-2?