How to Map Phecode to Corresponding ICD-9/ICD-10 Codes

[liaoming he]

Dear PheWeb-UMich Research Team,

I hope this message finds you well. I seek your assistance regarding an issue I encountered while accessing summary statistics through the PheWeb-UKB-SAIGE portal (https://pheweb.org/UKB-SAIGE/).

Specifically, I am unsure how to map Phecode to its corresponding ICD-9 or ICD-10 codes. For instance, when I search for “Cholelithiasis,” the portal displays the Phecode (574.1). However, the corresponding ICD-9/ICD-10 codes are not referenced.

As these ICD codes are critical for my analysis, I would greatly appreciate any guidance on how to resolve this issue. Could you advise on how to identify the ICD-9/ICD-10 codes associated with a specific Phecode in this portal?

Thank you in advance for your time and support. I look forward to your insights.

Best regards,

Liaoming

[Sarah Gagliano Taliun]

Thanks for your interest in PheWeb. 

For the PheWebs displaying GWASs for PheCodes in the UK Biobank, ICD codes were mapped to PheCodes using a published scheme (https://academic.oup.com/bioinformatics/article/30/16/2375/2748157). Please refer to the section "Phenotype definitions in UK Biobank" in the SAIGE paper (https://pmc.ncbi.nlm.nih.gov/articles/PMC6119127/), which was the tool used to run the GWASs for the UK Biobank PheWebs.

Hope this helps!

Sarah