Embryo

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Patricia Tran

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Oct 24, 2012, 7:20:58 PM10/24/12
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Not an all inclusive list, just what I remember him mentioning in group last year. Attached is the lineage map with the things he told me to highlight circled. Know where those circled things came from and the major things they go to.


Teratogens

-          Alcohol – FAS; IUGR

-          Isotretinoin – NTDs, thymic aplasia

-          MTX – skeletal defects (Face, cranium, limbs, vertebral column)

-          Misoprostol – Limb anomalies, ocular and CN defects, autism

-          Tetracycline – stained teeth, hypoplasia of enamel

-          Thalidomide – No limbs/limb buds

-          CMV – sensorineural hearing loss, hepatosplenomegaly, cerebral palsy

-          HSV – skin vesicles, hemolytic anemia, thrombocytopenia

-          Parvovirus B19 – anemia, hydrops fetalis, death

-          Rubella – cataracts at birth

-          T. gondii – micropthalmia, hydrocephaly, hearing loss

-          Varicella – scars in a dermatome, limb paresis, seizures, appendage skeletal hypoplasia, urogenital anomalies

Disorders

-          In addition to the table, add Hirschsprung/Congenital Megacolon

 

Patricia Tran
Mercer University School of Medicine

Lineage Map.pdf
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