His father was nephew of the 1st Lord Jessel, and double first cousin on the 2nd Lord Jessel:
Sir George Jessel (13 Feb 1824-21 Mar 1883); m.20 Aug 1856 Amelia Moses (d.27 Sep 1898)
1.Sir Charles James, cr Baronet 1883 (11 May 1860-15 Jul 1928); m.15 Jul 1890 Edith (d.1 Jan 1956), dau of Sir Julian Goldsmid, 3rd Bt.
1.1.Sir George, 2nd Bt. (17 May 1891-18 Aug 1977); m.1st 1 Feb 1923 Mrs Muriel Gladys Swetenham, née Chaplin (d.26 Jan 1948); m.2nd 7 Jun 1948 [Joan] Betty, née Ewart, formerly wife of 2nd Lord Russell of Liverpool
1.1.1.Sir Charles John, 3rd Bt. (29 Dec 1924-1 Apr 2022); m.1st 9 Jun 1956 Shirley Cornelia Waters (d.23 Oct 1977); m.2nd 1979 (div 1983) Gwendolyn Mary Devereux
2.Sir Herbert Merton, cr Baronet 1917, cr 1924 Baron Jessel, of Westminster (27 Oct 1866-1 Nov 1950); m.20 Dec 1894 Maud (d.28 Oct 1965), dau of Sir Julian Goldsmid, 3rd Bt.
2.1.Edward Herbert, 2nd Lord Jessel (25 Mar 1904-1990); m.1st 14 Feb 1935 (div 1960) Lady Helen Maglona Vane-Tempest-Stewart (8 Jul 1911-11 Mar 1986); m.2nd 20 Dec 1960 Jessica Marian de Wet