The O'Brien Baronetcy, of Merrion Square in Dublin and Boris-in-Ossory in Queen's County, was created in the Baronetage of the United Kingdom on 25 September 1849 for Timothy O'Brien. He was a merchant, Lord Mayor of Dublin and Liberal Member of Parliament for Cashel. The second Baronet represented King's County in the House of Commons as a Liberal for over thirty years. The third Baronet was Lord Lieutenant of County Cork.
In 2017 the seventh and present Baronet (Devin James Connor O’Brien) claimed succession and was listed in the Official Roll of the Baronetage. The baronetcy was considered temporarily dormant from 2013 to 2017 while this claim was verified.