The New England Journal of Medicine, April 21, 2022

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The New England Journal of Medicine

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JJ LUNGZ MD

Audio Summary This Week at NEJM.org, April 21, 2022

New Covid-19 Explore our collection of articles and resources on Covid-19. Intramuscular AZD7442 (Tixagevimab–Cilgavimab) for Prevention of Covid-19 M.J. Levin and Others DOI: 10.1056/NEJMoa2116620 | April 20, 2022 Perspective Physicians as Political Pawns — The Texas Directive on Gender-Affirming Care and Other Moves A. Kirkland DOI: 10.1056/NEJMp2203746 | April 20, 2022 Policy Strategies for Addressing Current Threats to the U.S. Nursing Workforce D.K. Costa and C.R. Friese DOI: 10.1056/NEJMp2202662 | April 20, 2022 Crossing Lines — A Change in the Leading Cause of Death among U.S. Children L.K. Lee, K. Douglas, and D. Hemenway N Engl J Med 2022;386:1485-1487 | Published Online April 16, 2022 Strengthening the Medicaid Reentry Act — Supporting the Health of People Who Are Incarcerated U.G. Khatri and T.N.A. Winkelman N Engl J Med 2022;386:1488-1490 | Published Online January 26, 2022 Covid-19’s Devastating Effect on Tuberculosis Care — A Path to Recovery M. Pai, T. Kasaeva, and S. Swaminathan N Engl J Med 2022;386:1490-1493 | Published Online January 5, 2022 Not Ready for the End Game — Why Ending Federal Covid-19 Emergency Declarations Will Harm Access to Care J.R. Horwitz and L.F. Wiley N Engl J Med 2022;386:e40 | Published Online April 6, 2022 Misusing Public Health as a Pretext to End Asylum — Title 42 A.G. Beckett, L. Viaud, M. Heisler, and J. Mukherjee N Engl J Med 2022;386:e41 | Published Online March 23, 2022 Original Articles Calorie Restriction with or without Time-Restricted Eating in Weight Loss D. Liu and Others N Engl J Med 2022;386:1495-1504 Reliever-Triggered Inhaled Glucocorticoid in Black and Latinx Adults with Asthma E. Israel and Others N Engl J Med 2022;386:1505-1518 | Published Online February 26, 2022 Ivosidenib and Azacitidine in IDH1-Mutated Acute Myeloid Leukemia P. Montesinos and Others N Engl J Med 2022;386:1519-1531 Covid-19 Vaccine Effectiveness against the Omicron (B.1.1.529) Variant N. Andrews and Others N Engl J Med 2022;386:1532-1546 | Published Online March 2, 2022 Review Article Increasing Incidence of Early-Onset Colorectal Cancer F.A. Sinicrope N Engl J Med 2022;386:1547-1558 Image Challenge What’s the diagnosis? Additional Published Content

Images in Clinical Medicine Larva Currens in Strongyloides Hyperinfection Syndrome M. Puerta-Peña and A. Calleja Algarra N Engl J Med 2022;386:1559 Congenital Diaphragmatic Hernia in an Adult H.-H. Liu and Y.-C. Liu N Engl J Med 2022;386:e42 | Published Online April 16, 2022 Case Records of the Massachusetts General Hospital Case 12-2022: A 41-Year-Old Woman with Transient Ischemic Attack and Mitral Valve Masses M.A. Matza and Others N Engl J Med 2022;386:1560-1570 Editorials Calorie and Time Restriction in Weight Loss B. Laferrère and S. Panda N Engl J Med 2022;386:1572-1573 Breaking the Skin Color Barriers for Asthma Medications — It’s Not Black, Brown, or White T. Bryant-Stephens N Engl J Med 2022;386:1574-1575 Audio Interview: The Effects of Covid-19 on Children E.J. Rubin, L.R. Baden, J.R. Ingelfinger, and S. Morrissey N Engl J Med 2022;386:e51 Clinical Implications of Basic Research Fighting Cardiac Fibrosis with CAR T Cells S.L. Friedman N Engl J Med 2022;386:1576-1578 Medicine and Society The Quality Movement — Part 2: Metric Myopia — Trading Away Our Clinical Judgment L. Rosenbaum DOI: 10.1056/NEJMms2200977 | April 20, 2022 Correspondence Neutralization of the SARS-CoV-2 Omicron BA.1 and BA.2 Variants Published Online March 16, 2022 Cardiovascular Events with Finerenone in CKD and Diabetes Determination of Brain Death Current Causes of Death in Children and Adolescents in the United States DOI: 10.1056/NEJMc2201761 | April 20, 2022 Intrinsic Severity of the SARS-CoV-2 Omicron Variant DOI: 10.1056/NEJMc2203679 | April 20, 2022 Physician Jobs April 21, 2022 Cardiology Arizona Tucson opportunity for heart failure physician The Advanced Heart Failure and Mechanical Circulatory Support Division of Cardiovascular Medicine at the University of Arizona, in partnership with the Banner University Medical Center in Tucson, AZ (BUMC-T) is seeking a BC/BE Invasive Non-Interventional Heart Failure Physician. The successful candidate will thrive in a fast-changing, multi-disciplinary environment. Ideally, candidates should have clinical expertise.... Chiefs/Directors/Dept. Heads Virginia Leadership role with PC group in Luray Unique opportunity to provide medical leadership and drive quality improvement throughout the primary care medical group. This opportunity will allow you to practice patient care in an outpatient setting boosting a well-established patient base. We seek an experienced physician leader with demonstrated record of improvement in quality of care. In this role, you will lead primary care council, analyze communication and action strategies.... Looking for a new practice opportunity? View these jobs and other listings at NEJM CareerCenter. Search now for both permanent and locum tenens jobs in many specialties. Subscribe to the New England Journal of Medicine The New England Journal of Medicine delivers the most significant, most clinically relevant research in medicine. Advance your knowledge with the information you trust to stay informed and improve patient care. Your subscription includes 52 weeks of NEJM.org access, 50 FREE article views from the NEJM Archive (1812-1989), and free access to all NEJM Weekly CME activities (Choose from over 350). Subscribe today. Question of the Week Which one of the following cardiac murmurs is most likely in a 22-year-old man with a history of acute rheumatic fever who presents with dyspnea? Midsystolic ejection murmur over the second right intercostal space Holosystolic murmur at the apex Systolic and diastolic machine-like murmur over the second left intercostal space Harsh systolic crescendo–decrescendo murmur in the second left intercostal space, radiating to the neck Holosystolic murmur, at the lower-left sternal border, that increases with inspiration

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