The New England Journal of Medicine, May 5, 2022

[NEJM]

The New England Journal of Medicine

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JJ LUNGZ MD

Audio Summary This Week at NEJM.org, May 5, 2022

CASE CHALLENGE A Man with Persistent Cough and Pulmonary Opacities A 57-year-old man with polyarteritis nodosa was evaluated for cough and pulmonary opacities. Chest CT revealed multifocal clustered centrilobular nodules and opacities in a tree-in-bud pattern. A galactomannan test was positive. What is the diagnosis? Vote and comment. Find the answers in the story text of the case, to be published on May 19. Browse more cases and challenge yourself at the Clinical Cases Resource Center.

New Covid-19 Explore our collection of articles and resources on Covid-19. Efficacy and Safety of the RBD-Dimer–Based Covid-19 Vaccine ZF2001 in Adults L. Dai and Others DOI: 10.1056/NEJMoa2202261 | May 4, 2022 Efficacy and Safety of a Recombinant Plant-Based Adjuvanted Covid-19 Vaccine K.J. Hager and Others DOI: 10.1056/NEJMoa2201300 | May 4, 2022 Does the World Still Need New Covid-19 Vaccines? H. Nohynek and A. Wilder-Smith DOI: 10.1056/NEJMe2204695 | May 4, 2022 Effectiveness of Ad26.COV2.S and BNT162b2 Vaccines against Omicron Variant in South Africa G. Gray and Others DOI: 10.1056/NEJMc2202061 | May 4, 2022 Perspective A Comprehensive Covid-19 Response — The Need for Economic Evaluation G. Persad and A. Pandya DOI: 10.1056/NEJMp2202828 | May 4, 2022 Your Money or Your Life — The High Cost of Cancer Drugs under Medicare Part D S.B. Dusetzina DOI: 10.1056/NEJMp2202726 | May 4, 2022 Designing Cures 2.0 — From Corridors to Cornerstones K.T. Kadakia and H.M. Krumholz N Engl J Med 2022;386:1677-1679 | Published Online April 30, 2022 Real-World Evidence — Where Are We Now? J. Concato and J. Corrigan-Curay N Engl J Med 2022;386:1680-1682 | Published Online April 30, 2022 Supporting Health Care Workers to Address Misinformation on Social Media V.M. Arora, E. Bloomgarden, and S. Jain N Engl J Med 2022;386:1683-1685 | Published Online March 30, 2022 Original Articles Two Phase 3 Trials of Baricitinib for Alopecia Areata B. King and Others N Engl J Med 2022;386:1687-1699 | Published Online March 26, 2022 Early Outpatient Treatment for Covid-19 with Convalescent Plasma D.J. Sullivan and Others N Engl J Med 2022;386:1700-1711 | Published Online March 30, 2022 Protection by a Fourth Dose of BNT162b2 against Omicron in Israel Y.M. Bar-On and Others N Engl J Med 2022;386:1712-1720 | Published Online April 5, 2022 Effect of Early Treatment with Ivermectin among Patients with Covid-19 G. Reis and Others N Engl J Med 2022;386:1721-1731 | Published Online March 30, 2022 Clinical Practice Nonspecific Low Back Pain A. Chiarotto and B.W. Koes N Engl J Med 2022;386:1732-1740 Image Challenge What’s the diagnosis? Additional Published Content

Images in Clinical Medicine Foreign-Body Aspiration in a Child K.M. Saar and C.R. Grindle N Engl J Med 2022;386:1741 | Published Online April 30, 2022 Primary Cutaneous Blastomycosis A. Alhatem and K.C. Smith N Engl J Med 2022;386:e49 Clinical Problem-Solving Looking Back L. Glick, L.A. Fitzpatrick, A.S. Detsky, and R.P. Rush N Engl J Med 2022;386:1742-1749 Editorials Baricitinib in Alopecia Areata A. Messenger and M. Harries N Engl J Med 2022;386:1751-1752 Convalescent Plasma for Covid-19 — Making Sense of the Inconsistencies L. Estcourt and J. Callum N Engl J Med 2022;386:1753-1754 Audio Interview: Do We Need New Covid-19 Vaccines? E.J. Rubin, L.R. Baden, and S. Morrissey N Engl J Med 2022;386:e52 Clinical Implications of Basic Research A New Image for Cell Sorting A. Filby and A.E. Carpenter N Engl J Med 2022;386:1755-1758 Medicine and Society The Quality Movement — Part 2: Metric Myopia — Trading Away Our Clinical Judgment L. Rosenbaum N Engl J Med 2022;386:1759-1763 | Published Online April 20, 2022 Correspondence Neutralization Profile after Recovery from SARS-CoV-2 Omicron Infection Published Online March 23, 2022 Cardiovascular and Cancer Risk with Tofacitinib in Rheumatoid Arthritis Trastuzumab Deruxtecan in Non–Small-Cell Lung Cancer Pembrolizumab in Early Triple-Negative Breast Cancer Physician Jobs May 5, 2022 Pulmonary/Critical Care South Carolina Seeking BC/BE physician for West Columbia practice Lexington Medical Center is seeking outstanding BC/BE Pulmonary Critical Care physicians to join its expanding its Intensivist program. Lexington Medical Center is a 557-bed acute care hospital network in West Columbia, South Carolina. In March of 2019, the Medical Center opened the doors to the largest clinical expansion in South Carolina's history. The network includes six community medical centers.... Hematology Colorado Northern Colorado opening for Hem/Onc generalist The Division of Cancer Medicine is actively recruiting a Hematologist/Oncologist (Generalist) to join our team at Banner MD Anderson Cancer Center in the Northern Colorado area. This unique candidate will join a national leader in multidisciplinary cancer care, education, and discovery. Banner Health is ranked in the top 10 healthcare systems nationwide. As a partner member of the MD Anderson Cancer Network®, our cancer program is a fully integrated, clinical extension of.... Looking for a new practice opportunity? View these jobs and other listings at NEJM CareerCenter. Search now for both permanent and locum tenens jobs in many specialties. Subscribe to the New England Journal of Medicine The New England Journal of Medicine delivers the most significant, most clinically relevant research in medicine. Advance your knowledge with the information you trust to stay informed and improve patient care. Your subscription includes 52 weeks of NEJM.org access, 50 FREE article views from the NEJM Archive (1812-1989), and free access to all NEJM Weekly CME activities (Choose from over 350). Subscribe today. Question of the Week What medical therapy is most appropriate for a patient with hematemesis who is otherwise hemodynamically stable, who has a clean-base stomach ulcer with no active bleeding, who has been treated with an initial bolus and an 8-hour continuous infusion of intravenous omeprazole, and whose follow-up hematocrit has been stable? Continue the intravenous omeprazole for 72 hours and then initiate oral omeprazole Continue the omeprazole infusion and recommend repeat endoscopy in 24 hours Discontinue the omeprazole infusion now and initiate oral omeprazole therapy Provide another bolus of intravenous omeprazole followed by oral omeprazole therapy Continue the omeprazole infusion for 24 hours and then initiate oral omeprazole

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