Weekend Briefing from NEJM.org

[NEJM]

View in browser

JJ LUNGZ MD SUBSCRIBE

Weekend Briefing November 21, 2020

 

WELCOME TO WEEKEND BRIEFING

Introducing a new weekly email alert from NEJM that brings you newly published articles and highlights trending content, this week’s CME activities, and popular features such as Quick Take videos, Visual Abstracts, and Images in Clinical Medicine.

IMAGES IN CLINICAL MEDICINE A 3-day-old boy presented with vomiting and inability to pass stools. A radiograph of the abdomen showed dilated colonic loops. Biopsy of the colon revealed an absence of ganglion cells, and a diagnosis of Hirschsprung’s disease was made. Read the article. VIEW MORE IMAGES »

To access the CME exam, look for the CME icon in the toolbar on the article page. ORIGINAL ARTICLE First-Line Lorlatinib or Crizotinib in Advanced ALK-Positive Lung Cancer REVIEW ARTICLE Endometrial Cancer CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL Case 36-2020: A 72-Year-Old Woman with Dark Urine and Weakness FIND MORE CME »

IMAGES IN CLINICAL MEDICINE LEARN MORE »

PERSPECTIVE Banning Genetic Discrimination in Life Insurance — Time to Follow Florida’s Lead M.A. Rothstein and K.B. Brothers Fear of discrimination by life insurance companies has been an obstacle to progress in the use of genetic technologies in medicine and research. A new Florida law will allow residents to undergo genetic testing without fear of the financial consequences of results. Read the article. PERSPECTIVE “You Are Now Entering a Guilt-free Zone” D.R. Taylor Patients who in late middle age have smoked 20 cigarettes a day since their teens constitute an at-risk group. One thing they’re clearly at risk for is the acute sense of guilt that a clinician can incite, which immediately makes a consultation tense. Read the article.

FACEBOOK A Randomized Trial Comparing Antibiotics with Appendectomy for Appendicitis TWITTER Rivaroxaban in Patients with Atrial Fibrillation and a Bioprosthetic Mitral Valve INSTAGRAM Perspective: The Inequity of Isolation

ORIGINAL ARTICLE SARS-CoV-2 Transmission among Marine Recruits during Quarantine A.G. Letizia and Others U.S. Marine Corps recruits quarantined at home for 2 weeks; after this period, 0.9% were found to be infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). During a second, supervised 2-week quarantine on a college campus, 1.9% had become newly infected, and most were asymptomatic. Read the article.

PERSPECTIVE Screen Time E. Rourke and N. Koscal This Graphic Perspective explores the triumphs and tribulations of caring for patients remotely in the Covid-19 era. Suddenly forced to use technology that may not be ready for prime time, a primary care physician and her patients discover its risks and benefits. Read the article. LISTEN TO THE PODCAST »

Lorlatinib versus Crizotinib in Advanced ALK-Positive Lung Cancer Read the related article. VIEW ALL QUICK TAKES »

Read the related article. VIEW ALL VISUAL ABSTRACTS »

Physician Jobs November 21, 2020 Chiefs/Directors New York Seeking Chief of Gastroenterology The Department of Medicine at Albany Medical College is seeking a Chief to lead our Division of Gastroenterology. The Division directs a Fellowship training program and has unique faculty expertise in hepatology, motility disorders, inflammatory bowel disease, pancreaticobiliary disease, and advanced endoscopy.... Critical Care Florida Night shift Critical Care physician Memorial Healthcare System is seeking a critical care physician, dedicated to night shifts, to join the critical care team. Successful candidates will have excellent clinical skills, a broad knowledge base in critical care, and be dedicated to providing high quality, evidence-based cares.… Looking for a new practice opportunity? View these jobs and other listings at NEJM CareerCenter. Search now for both permanents and locum tenens job in many specialties.

FOLLOW US

As a valued reader of NEJM, you are receiving this Weekend Briefing because you selected to receive the NEJM Weekly Table of Contents. The Weekend Briefing is a companion to the Table of Contents. To ensure consistent delivery of NEJM emails, please add webm...@n.nejm.org to your Contacts or Address Book. Click here to unsubscribe from Weekend Briefing. If you prefer not to receive content alerts, information about updates, services, or special offers from NEJM.org, sign in to My NEJM Alerts to update your email preferences. The New England Journal of Medicine 860 Winter Street Waltham, MA 02451 USA Copyright © 2020 Massachusetts Medical Society. All rights reserved.

[NEJM]

View in browser

JJ LUNGZ MD SUBSCRIBE

Weekend Briefing November 28, 2020

 

IMAGES IN CLINICAL MEDICINE A 29-year-old man presented with progressive skin lesions on the face, back, trunk, and limbs. Biopsy was performed, and a diagnosis of blastic plasmacytoid dendritic-cell neoplasm was made. Read the article. VIEW MORE IMAGES »

To access the CME exam, look for the CME icon in the toolbar on the article page.

ORIGINAL ARTICLE

Once-Weekly Insulin for Type 2 Diabetes without Previous Insulin Treatment ORIGINAL ARTICLE

Rivaroxaban in Patients with Atrial Fibrillation and a Bioprosthetic Mitral Valve

ORIGINAL ARTICLE A Randomized Trial of Laryngeal Mask Airway in Neonatal Resuscitation FIND MORE CME »

IMAGES IN CLINICAL MEDICINE LEARN MORE »

PERSPECTIVE The NAM at 50: Solving Population-wide Obesity — Progress and Future Prospects S. Kumanyika and W.H. Dietz The global obesity rate has tripled since the mid-1970s. Major investments have been made in this area, and there have been some legislative and regulatory successes. But addressing obesity and other major health threats in concert could enable more effective solutions. Read the article. PERSPECTIVE The Bottom of the Health Care Rationing Iceberg T. Lahey Here I was, trying to do a perfect job allocating a handful of mechanical ventilators for an unprecedented viral pandemic, while every day the entire health care system fails utterly to fairly allocate all kinds of health care to an enormous number of vulnerable people. Read the article. PERSPECTIVE From Portraits to Role Models — Why We Need Black Physicians in Academic Medicine A.V. Owoseni To become something, you must see it first — whether in the faces of those who have gone before you or in your own mind. The importance of role models is one reason why representation in medicine matters, because Black students need to see people who look like future versions of themselves. Read the article.

FACEBOOK Rapid Response to an Outbreak in Qingdao, China TWITTER An Unexpected Education — Unclaimed Bodies in the Anatomy Lab INSTAGRAM Killing the Pathogen and Sparing the Placenta

ORIGINAL ARTICLE

An mRNA Vaccine against SARS-CoV-2 — Preliminary Report L.A. Jackson and Others Two inoculations with a new SARS-CoV-2 mRNA-based vaccine that encodes a protein in the coronavirus spike elicited high titers of virus-neutralizing antibody in healthy adult volunteers. Virus-specific T-cell responses were also elicited. Interim findings indicated that a dose of 100 μg per injection maximized immune response and minimized the reactogenicity of the vaccine. Read the article.

PERSPECTIVE Delaying Pregnancy during a Public Health Crisis — Examining Public Health Recommendations for Covid-19 and Beyond S.A. Rasmussen, A.D. Lyerly, and D.J. Jamieson

Whether public health agencies should recommend that women avoid becoming pregnant during public health crises like Covid-19 because of potential risks to themselves and their newborns has been controversial. Such discussions involve important ethical considerations. Read the article. LISTEN TO THE PODCAST »

Once-Weekly Insulin for Type 2 Diabetes

Read the related article. VIEW ALL QUICK TAKES »

Read the related article. VIEW ALL VISUAL ABSTRACTS »

Physician Jobs November 28, 2020 Cardiology Nebraska Seeking FT Cardiologist in Scottsbluff Our well-established cardiology program is adding a full-time, fellowship-trained non-invasive or invasive cardiologist, board certified in internal medicine and board eligible/certified cardiovascular disease. Here are a few good reasons to join our cardiology team in Scottsbluff.... Internal Medicine Colorado Denver opportunity for IM physician Our established and busy practice in Cherry Creek is seeking a board-certified, patient-driven internal medicine physician to join our premier primary care practice in Denver. This is an exceptional opportunity to be part of a collaborative and dynamic team. Live your passion.…

Looking for a new practice opportunity? View these jobs and other listings at NEJM CareerCenter. Search now for both permanents and locum tenens job in many specialties.

FOLLOW US

As a valued reader of NEJM, you are receiving this Weekend Briefing because you selected to receive the NEJM Weekly Table of Contents. The Weekend Briefing is a companion to the Table of Contents. To ensure consistent delivery of NEJM emails, please add webm...@n.nejm.org to your Contacts or Address Book. Click here to unsubscribe from Weekend Briefing. If you prefer not to receive content alerts, information about updates, services, or special offers from NEJM.org, sign in to My NEJM Alerts to update your email preferences. The New England Journal of Medicine 860 Winter Street Waltham, MA 02451 USA Copyright © 2020 Massachusetts Medical Society. All rights reserved.

[NEJM]

View in browser

JJ LUNGZ MD SUBSCRIBE

Weekend Briefing December 5, 2020

  

Register now: “Chasing Science to Save Lives” with Anthony Fauci, M.D.

On December 9, 3–4 pm ET, watch Dr. Anthony Fauci deliver the latest on the pandemic in part 6 of “When Public Health Means Business.” Register >>

IMAGES IN CLINICAL MEDICINE A 62-year-old man with hypercapnic respiratory failure was intubated, and a propofol infusion was initiated. Five days after admission, his urine became green. Read the article. VIEW MORE IMAGES »

To access the CME exam, look for the CME icon in the toolbar on the article page.

ORIGINAL ARTICLE

Pembrolizumab in Microsatellite-Instability–High Advanced Colorectal Cancer ORIGINAL ARTICLE Effect of Finerenone on Chronic Kidney Disease Outcomes in Type 2 Diabetes CLINICAL PROBLEM-SOLVING Looking for the Outsider FIND MORE CME »

IMAGES IN CLINICAL MEDICINE LEARN MORE »

PERSPECTIVE The Discovery of Hepatitis C — The 2020 Nobel Prize in Physiology or Medicine J.H. Hoofnagle and S.M. Feinstone The discovery of HCV was a major milestone in 20th-century medicine, and the 2020 Nobel awardees represent three critical periods of research on this important virus. Their discovery led to elimination of post-transfusion hepatitis and a means to cure hepatitis C. Read the article. PERSPECTIVE Broken Promises — How Medicare Part D Has Failed to Deliver Savings to Older Adults S.B. Dusetzina, B. Muluneh, N.L. Keating, and H.A. Huskamp For expensive specialty drugs, it’s unclear how quickly substantial price competition among generics manufacturers can be achieved. Even if generic specialty drugs have far lower list prices than brand-name versions, savings may not accrue to Medicare beneficiaries. Read the article.

FACEBOOK Women Physicians and Promotion in Academic Medicine TWITTER N-of-1 Trial of a Statin, Placebo, or No Treatment to Assess Side Effects INSTAGRAM

Banning Genetic Discrimination in Life Insurance — Time to Follow Florida’s Lead

ORIGINAL ARTICLE

A Randomized Trial of Convalescent Plasma in Covid-19 Severe Pneumonia V.A. Simonovich and Others Hospitalized adults with severe Covid-19 pneumonia were randomly assigned in a 2:1 ratio to receive convalescent plasma or placebo. At 30 days, no significant difference in clinical status was noted between the two groups. Overall mortality was 11.43% with placebo and 10.96% with convalescent plasma, a difference that was not significant. Read the article.

PERSPECTIVE Solving Population-wide Obesity — Progress and Future Prospects

S. Kumanyika and W.H. Dietz

The global obesity rate has tripled since the mid-1970s. Major investments have been made in this area, and there have been some legislative and regulatory successes. But addressing obesity and other major health threats in concert could enable more effective solutions. Read the article.

LISTEN TO THE PODCAST »

Effect of Finerenone on Chronic Kidney Disease Outcomes in Type 2 Diabetes

Read the related article. VIEW ALL QUICK TAKES »

Read the related article. VIEW ALL VISUAL ABSTRACTS »

Physician Jobs December 5, 2020

Cardiology Nebraska Seeking FT Cardiologist in Scottsbluff Our well-established cardiology program is adding a full-time, fellowship-trained non-invasive or invasive cardiologist, board certified in internal medicine and board eligible/certified cardiovascular disease. Here are a few good reasons to join our cardiology team in Scottsbluff.... Internal Medicine Colorado

Opportunity for IM physician in Longmont Enjoy beautiful Longmont, Colorado as a full-time Internal Medicine physician. At UCHealth, our mission is simple - to improve lives. That starts with you. We help you live your passion of providing personalized, evidence-based patient care at the highest level. Join our growing practice at UCHealth.…

Looking for a new practice opportunity? View these jobs and other listings at NEJM CareerCenter. Search now for both permanents and locum tenens job in many specialties.

FOLLOW US

As a valued reader of NEJM, you are receiving this Weekend Briefing because you selected to receive the NEJM Weekly Table of Contents. The Weekend Briefing is a companion to the Table of Contents. To ensure consistent delivery of NEJM emails, please add webm...@n.nejm.org to your Contacts or Address Book. Click here to unsubscribe from Weekend Briefing. If you prefer not to receive content alerts, information about updates, services, or special offers from NEJM.org, sign in to My NEJM Alerts to update your email preferences. The New England Journal of Medicine 860 Winter Street Waltham, MA 02451 USA Copyright © 2020 Massachusetts Medical Society. All rights reserved.

[NEJM]

View in browser

JJ LUNGZ MD SUBSCRIBE

Weekend Briefing December 12, 2020

  

IMAGES IN CLINICAL MEDICINE A 46-year-old man presented with diarrhea, weight loss, and abdominal pain and was found to have acute kidney injury. A renal biopsy was performed, and a diagnosis of renal cryptococcosis was made. Read the article. VIEW MORE IMAGES »

To access the CME exam, look for the CME icon in the toolbar on the article page.

ORIGINAL ARTICLE

Efficacy of Tocilizumab in Patients Hospitalized with Covid-19 ORIGINAL ARTICLE Survival with Olaparib in Metastatic Castration-Resistant Prostate Cancer REVIEW ARTICLE Spontaneous Coronary-Artery Dissection FIND MORE CME »

IMAGES IN CLINICAL MEDICINE LEARN MORE »

PERSPECTIVE Health Coverage and Care for Transgender People — Threats and Opportunities D. Stroumsa and A.R. Kirkland The fate of Russell Toomey’s case against Arizona, and of other transgender Americans’ access to care, depends on the influence of Bostock v. Clayton County. Meanwhile, the new administration and Congress should undo recent damage to transgender rights protections. Read the article. PERSPECTIVE Failed Assignments — Rethinking Sex Designations on Birth Certificates V.M. Shteyler, J.A. Clarke, and E.Y. Adashi Sex designations on birth certificates offer no clinical utility, and they can be harmful for intersex and transgender people. Moving such designations below the line of demarcation wouldn’t compromise the birth certificate’s public health function but could avoid harm. Read the article. PERSPECTIVE The Caregiver A. Gupta The young triathlete with brain metastases has rapidly become debilitated. But his wife, a cancer survivor, has a sagelike calm, born in part of experience volunteering with dying children. Her husband — and his oncologist — are fortunate to have such a caregiver. Read the article.

FACEBOOK Cytokine Storm TWITTER CRISPR-Cas9 Gene Editing for Sickle Cell Disease and β-Thalassemia INSTAGRAM

From Portraits to Role Models — Why We Need Black Physicians in Academic Medicine

ORIGINAL ARTICLE

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine F.P. Polack and Others A vaccine containing an RNA molecule encoding the SARS-CoV-2 spike protein was tested in a trial in which two injections were given 3 weeks apart. After the second injection, Covid-19 developed in 162 patients receiving placebo, with a median follow-up of 2 months, and in 8 patients receiving the vaccine. Side effects were mainly mild-to-moderate injection-site pain and swelling. Read the article.

PERSPECTIVE The Discovery of Hepatitis C — The 2020 Nobel Prize in Physiology or Medicine

J.H. Hoofnagle and S.M. Feinstone

The discovery of HCV was a major milestone in 20th-century medicine, and the 2020 Nobel awardees represent three critical periods of research on this important virus. Their discovery led to elimination of post-transfusion hepatitis and a means to cure hepatitis C. Read the article.

LISTEN TO THE PODCAST »

Evinacumab in Refractory Hypercholesterolemia

Read the related article. VIEW ALL QUICK TAKES »

Read the related article. VIEW ALL VISUAL ABSTRACTS »

Physician Jobs December 12, 2020

[NEJM]

View in browser

JJ LUNGZ MD SUBSCRIBE

Weekend Briefing December 19, 2020

  

IMAGES IN CLINICAL MEDICINE A 50-year-old man with recently diagnosed lung cancer presented with shortness of breath and a cough. Water-soluble contrast esophagography (shown in a video) revealed a bronchoesophageal fistula. Read the article. VIEW MORE IMAGES »

To access the CME exam, look for the CME icon in the toolbar on the article page.

ORIGINAL ARTICLE

Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults CLINICAL PRACTICE Severe Covid-19

CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL

Case 39-2020: A 29-Month-Old Boy with Seizure and Hypocalcemia FIND MORE CME »

IMAGES IN CLINICAL MEDICINE LEARN MORE »

PERSPECTIVE The Gift R. Rush The man had been admitted many times, and he knew what my sweat and repositioning implied and what my repeated offers to stop the procedure meant. I had spent the afternoon exposing my inexperience clearly. In response, he had offered himself. Read the article.

FACEBOOK Emergence of a Highly Fit SARS-CoV-2 Variant TWITTER

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

INSTAGRAM SARS-CoV-2 Vaccination — An Ounce (Actually, Much Less) of Prevention

ORIGINAL ARTICLE

REGN-COV2, a Neutralizing Antibody Cocktail, in Outpatients with Covid-19 D.M. Weinreich and Others An anti–SARS-CoV-2 antibody cocktail was given to patients within 3 days after PCR confirmation of Covid-19. In patients who were antibody-negative at baseline, treatment was associated with rapid viral clearance and potentially with a less frequent need for medical attention. The effect was less marked among patients who were antibody-positive at baseline. Read the article.

PERSPECTIVE Health Coverage and Care for Transgender People — Threats and Opportunities

D. Stroumsa and A.R. Kirkland

The fate of Russell Toomey’s case against Arizona, and of other transgender Americans’ access to care, depends on the influence of Bostock v. Clayton County. Meanwhile, the new administration and Congress should undo recent damage to transgender rights protections. Read the article.

LISTEN TO THE PODCAST »

Phase 1 Study of a SARS-CoV-2 mRNA Vaccine in Older Adults

Read the related article. VIEW ALL QUICK TAKES »

Read the related article. VIEW ALL VISUAL ABSTRACTS »

Physician Jobs December 19, 2020

[NEJM]

View in browser

JJ LUNGZ MD SUBSCRIBE

Weekend Briefing December 26, 2020

  

IMAGES IN CLINICAL MEDICINE A 60-year-old man with sickle cell disease presented with fatigue and shortness of breath. He was found to have anemia, and bone marrow biopsy revealed hemophagocytosis of sickle cells. Read the article. VIEW MORE IMAGES »

To access the CME exam, look for the CME icon in the toolbar on the article page.

ORIGINAL ARTICLE

Changes in Seizure Frequency and Antiepileptic Therapy during Pregnancy REVIEW ARTICLE Systemic Therapy for Estrogen Receptor–Positive, HER2-Negative Breast Cancer

CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL

Case 40-2020: A 24-Year-Old Man with Headache and Covid-19 FIND MORE CME »

IMAGES IN CLINICAL MEDICINE LEARN MORE »

PERSPECTIVE Essential but Undefined — Reimagining How Policymakers Identify Safety-Net Hospitals P. Chatterjee, B.D. Sommers, and K.E. Joynt Maddox Safety-net hospitals provide essential care to patients regardless of their insurance coverage, financial circumstances, or immigration status, and they often operate with thin margins. But the lack of a clear definition for safety-net hospitals presents challenges. Read the article. PERSPECTIVE Medicaid and Child Health Equity J.M. Perrin, G.M. Kenney, and S. Rosenbaum For children, no other insurer has equaled Medicaid’s comprehensive coverage and cost-sharing protections. But Medicaid also has important limitations, and the imperative to achieve racial and socioeconomic health equity demands structural changes to the program. Read the article. PERSPECTIVE Whiteout E.J. Rourke Two New England blizzards, two patients dying alone, and one resident desperate to bring their loved ones safely to their side for a final goodbye. Could one patient’s “good” death undo the harm of the other patient’s “bad” death? Read the article.

FACEBOOK Tocilizumab in Patients Hospitalized with Covid-19 Pneumonia TWITTER A Neutralizing Monoclonal Antibody for Hospitalized Patients with Covid-19 INSTAGRAM

Failed Assignments — Rethinking Sex Designations on Birth Certificates

ORIGINAL ARTICLE

Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19 A.C. Kalil and Others In a trial involving 1033 patients hospitalized with Covid-19, the addition of baricitinib to remdesivir was associated with shorter recovery time, particularly among patients receiving high-flow oxygen, and with a 30% higher odds of improvement at day 15 than remdesivir alone. Adverse events were less frequent with the combination therapy. Read the article.

PERSPECTIVE The Gift R. Rush

The man had been admitted many times, and he knew what my sweat and repositioning implied and what my repeated offers to stop the procedure meant. I had spent the afternoon exposing my inexperience clearly. In response, he had offered himself. Read the article.

LISTEN TO THE PODCAST »

Ultrasound Subthalamotomy for Parkinson’s Disease

Read the related article. VIEW ALL QUICK TAKES »

Read the related article. VIEW ALL VISUAL ABSTRACTS »

Physician Jobs December 26, 2020 Cardiology Colorado Seeking FT Cardiologist in Colorado Springs The UCHealth Heart and Vascular team in Colorado Springs is adding a full-time, fellowship trained in Advanced Heart Failure and Transplant Cardiology. Board certification in Internal Medicine and Cardiovascular Disease are required. Here are a few good reasons to join our cardiology team in Colorado Springs.... Family Medicine Colorado Seeking full-time FM physician in Firestone UCHealth Medical Group is ready to welcome a full-time Family Medicine physician who is enthusiastic and patient-driven to join our collegial and high-functioning practice at in Firestone, CO - less than 30 miles from Denver. The ideal candidate will have a minimum of two years of experience and be board eligible/certified.…

Looking for a new practice opportunity? View these jobs and other listings at NEJM CareerCenter. Search now for both permanents and locum tenens job in many specialties.

FOLLOW US

As a valued reader of NEJM, you are receiving this Weekend Briefing because you selected to receive the NEJM Weekly Table of Contents. The Weekend Briefing is a companion to the Table of Contents. To ensure consistent delivery of NEJM emails, please add webm...@n.nejm.org to your Contacts or Address Book. Click here to unsubscribe from Weekend Briefing. If you prefer not to receive content alerts, information about updates, services, or special offers from NEJM.org, sign in to My NEJM Alerts to update your email preferences. The New England Journal of Medicine 860 Winter Street Waltham, MA 02451 USA Copyright © 2020 Massachusetts Medical Society. All rights reserved.

[NEJM]

View in browser

JJ LUNGZ MD SUBSCRIBE

Weekend Briefing January 2, 2021

  

IMAGES IN CLINICAL MEDICINE A 35-year-old man presented with painless swelling in the right lower leg. Magnetic resonance imaging revealed a large, well-defined cystic lesion with multiple daughter cysts, a finding consistent with echinococcal cysts. Read the article. VIEW MORE IMAGES »

To access the CME exam, look for the CME icon in the toolbar on the article page.

ORIGINAL ARTICLE

Trial of Dexamethasone for Chronic Subdural Hematoma ORIGINAL ARTICLE Higher or Lower Hemoglobin Transfusion Thresholds for Preterm Infants

CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL

Case 41-2020: A 62-Year-Old Man with Memory Loss and Odd Behavior FIND MORE CME »

IMAGES IN CLINICAL MEDICINE LEARN MORE »

PERSPECTIVE Human Molecular Genetics and Genomics — Important Advances and Exciting Possibilities F.S. Collins, J.A. Doudna, E.S. Lander, and C.N. Rotimi Genomic research has evolved from seeking to understand the fundamentals of the human genetic code to examining the ways in which this code varies among people, and then applying this knowledge to interventions that are tailored to target the underlying causes of disease. Read the article.

FACEBOOK Antibody Status and Incidence of SARS-CoV-2 Infection in Health Care Workers TWITTER

Systemic Therapy for Estrogen Receptor–Positive, HER2-Negative Breast Cancer

INSTAGRAM The Gift

ORIGINAL ARTICLE

Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine L.R. Baden and Others Two injections of mRNA-1273, a lipid nanoparticle–encapsulated mRNA-based vaccine produced in collaboration with the NIAID that encodes the SARS-CoV-2 spike protein, conferred protection against Covid-19 illness in 94% of vaccinated patients. Adverse effects of the vaccine were mild, transient local reactions, and the incidence of systemic effects such as fever, headache, and fatigue was low. Read the article.

PERSPECTIVE Essential but Undefined — Reimagining How Policymakers Identify Safety-Net Hospitals

P. Chatterjee, B.D. Sommers, and K.E. Joynt Maddox

Safety-net hospitals provide essential care to patients regardless of their insurance coverage, financial circumstances, or immigration status, and they often operate with thin margins. But the lack of a clear definition for safety-net hospitals presents challenges. Read the article.

LISTEN TO THE PODCAST »

Higher or Lower Hemoglobin Transfusion Thresholds for Preterm Infants

Read the related article. VIEW ALL QUICK TAKES »

Read the related article. VIEW ALL VISUAL ABSTRACTS »

Physician Jobs January 2, 2021

Cardiology Colorado Seeking FT Cardiologist in Colorado Springs The UCHealth Heart and Vascular team in Colorado Springs is adding a full-time, fellowship trained in Advanced Heart Failure and Transplant Cardiology. Board certification in Internal Medicine and Cardiovascular Disease are required. Here are a few good reasons to join our cardiology team in Colorado Springs.... Family Medicine Colorado Seeking full-time FM physician in Firestone UCHealth Medical Group is ready to welcome a full-time Family Medicine physician who is enthusiastic and patient-driven to join our collegial and high-functioning practice at in Firestone, CO - less than 30 miles from Denver. The ideal candidate will have a minimum of two years of experience and be board eligible/certified.… Looking for a new practice opportunity? View these jobs and other listings at NEJM CareerCenter. Search now for both permanents and locum tenens job in many specialties.

FOLLOW US

As a valued reader of NEJM, you are receiving this Weekend Briefing because you selected to receive the NEJM Weekly Table of Contents. The Weekend Briefing is a companion to the Table of Contents. To ensure consistent delivery of NEJM emails, please add webm...@n.nejm.org to your Contacts or Address Book. Click here to unsubscribe from Weekend Briefing. If you prefer not to receive content alerts, information about updates, services, or special offers from NEJM.org, sign in to My NEJM Alerts to update your email preferences.

The New England Journal of Medicine 860 Winter Street Waltham, MA 02451 USA

Copyright © 2021 Massachusetts Medical Society. All rights reserved.

[NEJM]

View in browser

JJ LUNGZ MD SUBSCRIBE

Weekend Briefing January 9, 2021

  

IMAGES IN CLINICAL MEDICINE A 45-year-old man presented to the emergency department after a motorcycle accident. A pelvic radiograph showed widening of the pubic symphysis, an injury known as an open-book fracture. Read the article. VIEW MORE IMAGES »

To access the CME exam, look for the CME icon in the toolbar on the article page.

ORIGINAL ARTICLE

Dipeptidyl Peptidase 4 Inhibition for Prophylaxis of Acute Graft-versus-Host Disease ORIGINAL ARTICLE Phase 3 Trial of Interleukin-1 Trap Rilonacept in Recurrent Pericarditis CLINICAL PRACTICE Osteoarthritis of the Knee FIND MORE CME »

IMAGES IN CLINICAL MEDICINE LEARN MORE »

PERSPECTIVE The Purdue Pharma Opioid Settlement — Accountability, or Just the Cost of Doing Business? C.S. Davis Over the objections of numerous members of Congress, state attorneys general, and families of people killed by opioids, Purdue Pharma and the Sacklers were permitted to enter into plea agreements that resolve all current federal criminal and civil charges against them. Read the article. PERSPECTIVE Drug-Coated Devices for Peripheral Arterial Disease A. Farb, M. Malone, and W.H. Maisel Recent analyses provide reassurance about using paclitaxel-coated devices in patients with peripheral arterial disease, but the FDA believes that clinical studies of these devices should continue and should collect long-term mortality data. Read the article. PERSPECTIVE Doctor as Street-Level Bureaucrat E.H. Geng Doctors are street-level bureaucrats, making decisions that can have particularly significant effects on vulnerable people. Often when we’re faced with a choice between defending the system and advocating for the patient, we instinctively do the former. Read the article.

FACEBOOK Breathing for Two TWITTER Early High-Titer Plasma Therapy to Prevent Severe Covid-19 in Older Adults INSTAGRAM Whiteout

REVIEW ARTICLE Maintaining Safety with SARS-CoV-2 Vaccines M.C. Castells and E.J. Phillips The vast majority of people who have received the Covid-19 vaccine to date have had self-limited local or low-grade systemic reactions that resolve within 2 or 3 days. A very small number of people have had serious anaphylactic reactions requiring catecholamine infusion and respiratory support. It is important to survey patients in advance of vaccination for allergic responses and to be aware of the early signs of an immediate hypersensitivity reaction. Read the article.

PERSPECTIVE Human Molecular Genetics and Genomics — Important Advances and Exciting Possibilities

F.S. Collins, J.A. Doudna, E.S. Lander, and C.N. Rotimi

Genomic research has evolved from seeking to understand the fundamentals of the human genetic code to examining the ways in which this code varies among people, and then applying this knowledge to interventions that are tailored to target the underlying causes of disease. Read the article.

LISTEN TO THE PODCAST »

Sitagliptin Prevention of Acute Graft-versus-Host Disease

Read the related article. VIEW ALL QUICK TAKES »

Read the related article. VIEW ALL VISUAL ABSTRACTS »

Physician Jobs January 9, 2021 Family Medicine Wisconsin Seeking FM physician in Janesville We are seeking a talented, engaged, and committed Board Eligible or Board Certified Family Medicine Physician who has a proven ability to engage with their colleagues and patients and who shares our dedication to exceptional care and outcomes..... Family Medicine Missouri FM opportunity in Bridgeton SSM Health is a Catholic not-for-profit health system serving the comprehensive health needs of communities across the Midwest through a robust and fully integrated health care delivery system. Headquartered in St. Louis, SSM Health has care delivery sites in Missouri.…

Looking for a new practice opportunity? View these jobs and other listings at NEJM CareerCenter. Search now for both permanents and locum tenens job in many specialties.

FOLLOW US

As a valued reader of NEJM, you are receiving this Weekend Briefing because you selected to receive the NEJM Weekly Table of Contents. The Weekend Briefing is a companion to the Table of Contents. To ensure consistent delivery of NEJM emails, please add webm...@n.nejm.org to your Contacts or Address Book. Click here to unsubscribe from Weekend Briefing. If you prefer not to receive content alerts, information about updates, services, or special offers from NEJM.org, sign in to My NEJM Alerts to update your email preferences. The New England Journal of Medicine 860 Winter Street Waltham, MA 02451 USA Copyright © 2021 Massachusetts Medical Society. All rights reserved.

[NEJM]

View in browser

JJ LUNGZ MD SUBSCRIBE

Weekend Briefing January 16, 2021

  

Covid-19 Vaccine Resources: Your Questions Answered

Visit the new Covid-19 Vaccine Resource Center to stay informed with free access to important articles, FAQs, and related resources that provide practical guidance for your practice and patients.

IMAGES IN CLINICAL MEDICINE An 83-year-old man presented with fatigue, weight loss, and postural hypotension. Computed tomography of the abdomen revealed marked enlargement of both adrenal glands, and a diagnosis of primary adrenal lymphoma was made. Read the article. VIEW MORE IMAGES »

To access the CME exam, look for the CME icon in the toolbar on the article page.

ORIGINAL ARTICLE

Sotagliflozin in Patients with Diabetes and Recent Worsening Heart Failure ORIGINAL ARTICLE Bupropion and Naltrexone in Methamphetamine Use Disorder REVIEW ARTICLE Ewing’s Sarcoma FIND MORE CME »

IMAGES IN CLINICAL MEDICINE LEARN MORE »

PERSPECTIVE Testing in a Pandemic — Improving Access, Coordination, and Prioritization Y. Botti-Lodovico, E. Rosenberg, and P.C. Sabeti The enormous U.S. toll of Covid-19 is attributable in part to the lack of an effective testing regimen. But by building distributed capacity and prioritizing resources appropriately, we can change our trajectory in fighting this pandemic and preempting future ones. Read the article. PERSPECTIVE Incarceration and Social Death — Restoring Humanity in the Clinical Encounter B.A. Salhi and A.D. Osborne Hospitals may intersect with the carceral system and participate in processes of “social death,” in which a person is treated as a nonperson and discounted in social terms. But the clinical encounter can resist rather than reinforce the process of social death. Read the article.

FACEBOOK (A Little) Clarity on Convalescent Plasma for Covid-19 TWITTER The Rapid Rise in Cutaneous Melanoma Diagnoses INSTAGRAM In Search of a Better Equation — Performance and Equity in Estimates of Kidney Function

ORIGINAL ARTICLE

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

F.P. Polack and Others A vaccine containing an RNA molecule encoding the SARS-CoV-2 spike protein was tested in a trial in which two injections were given 3 weeks apart. After the second injection, Covid-19 developed in 162 patients receiving placebo, with a median follow-up of 2 months, and in 8 patients receiving the vaccine. Side effects were mainly mild-to-moderate injection-site pain and swelling. Read the article.

PERSPECTIVE The Purdue Pharma Opioid Settlement — Accountability, or Just the Cost of Doing Business? C.S. Davis

Over the objections of numerous members of Congress, state attorneys general, and families of people killed by opioids, Purdue Pharma and the Sacklers were permitted to enter into plea agreements that resolve all current federal criminal and civil charges against them. Read the article.

LISTEN TO THE PODCAST »

Cardiac Myosin Activation with Omecamtiv Mecarbil in Systolic Heart Failure

Read the related article. VIEW ALL QUICK TAKES »

Read the related article. VIEW ALL VISUAL ABSTRACTS »

Physician Jobs January 16, 2021

[NEJM]

View in browser

JJ LUNGZ MD SUBSCRIBE

Weekend Briefing January 23, 2021

  

Covid-19 Vaccine Resources: Your Questions Answered

Visit the new Covid-19 Vaccine Resource Center to stay informed with free access to important articles, FAQs, and related resources that provide practical guidance for your practice and patients.

IMAGES IN CLINICAL MEDICINE A 7-year-old girl presented with fever and painful blisters on her arms, legs, and face. On hospital day 5, a new skin ulcer developed at an intravenous cannula site. Biopsy results were consistent with a neutrophilic dermatosis. Read the article. VIEW MORE IMAGES »

To access the CME exam, look for the CME icon in the toolbar on the article page.

ORIGINAL ARTICLE

Post-Transcriptional Genetic Silencing of BCL11A to Treat Sickle Cell Disease ORIGINAL ARTICLE Polypill with or without Aspirin in Persons without Cardiovascular Disease

CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL

Case 2-2021: A 26-Year-Old Pregnant Woman with Ventricular Tachycardia and Shock FIND MORE CME »

IMAGES IN CLINICAL MEDICINE LEARN MORE »

PERSPECTIVE At the Cusp — Reimagining Infective Endocarditis Care amid the Opioid Epidemic M.A. Incze The opioid epidemic has transformed the epidemiology of infective endocarditis. Treatment models focused on managing acute complications could be expanded to encompass substance use disorder treatment, intensive case management, supportive housing, and primary care. Read the article. PERSPECTIVE Toward a Medical “Ecology of Attention” M.J. Kissler, K. Kissler, and M. Burden As we continually try to optimize the systems in which we work, we should think ambitiously about clinical environments that optimize attention. A shift to attentive work could improve quality, efficiency, and patient and provider satisfaction and reduce costs of care. Read the article. PERSPECTIVE The Surgeon and the Mother H. Carmichael I did not get to hold you for the first 3 weeks of your life. I knew this would happen. I was the surgeon, and I was prepared. But slowly, over those first weeks, my surgical armor shifted, slipped, cracked, as you gradually opened your eyes and claimed me as your own. Read the article.

FACEBOOK Cardiac Myosin Activation with Omecamtiv Mecarbil in Systolic Heart Failure TWITTER Spinal Cord Injury — Healing from Within INSTAGRAM Ewing’s Sarcoma

ORIGINAL ARTICLE

Interim Results of a Phase 1–2a Trial of Ad26.COV2.S Covid-19 Vaccine J. Sadoff and Others In this interim phase 1–2a trial of an adenovirus-based vaccine (Ad26.COV2.S), participants were divided into two age groups and received one or two injections of either a low-dose or high-dose vaccine or placebo. The vaccine elicited a local injection response in most patients and high titers of neutralizing antibodies in all vaccinated groups. In addition, T-cell responses were noted. Read the article.

PERSPECTIVE Testing in a Pandemic — Improving Access, Coordination, and Prioritization

Y. Botti-Lodovico, E. Rosenberg, and P.C. Sabeti

The enormous U.S. toll of Covid-19 is attributable in part to the lack of an effective testing regimen. But by building distributed capacity and prioritizing resources appropriately, we can change our trajectory in fighting this pandemic and preempting future ones. Read the article.

LISTEN TO THE PODCAST »

CRISPR-Cas9 Gene Editing for SCD and TDT

Read the related article. VIEW ALL QUICK TAKES »

Read the related article. VIEW ALL VISUAL ABSTRACTS »

Physician Jobs January 23, 2021 Pulmonary Disease Oklahoma Seeking BC Pulmonologist in Oklahoma City SSM Health Medical Group in Oklahoma City, OK is seeking a talented, board certified Pulmonologist to be a part of our Pulmonology Team. One who has a proven ability to engage with their colleagues and patients and who share our dedication to exceptional care and outcomes..... Psychiatry Wisconsin Seeking adult Psychiatrist in Fond du Lac Agnesian Healthcare is actively recruiting a full-time (1.0FTE) Adult Psychiatrist to join our experienced and cohesive outpatient behavioral health team consisting of six Psychiatrists and about 11 Psychotherapists (Masters Therapists and Psychologists) in an outpatient clinic setting.…

Looking for a new practice opportunity? View these jobs and other listings at NEJM CareerCenter. Search now for both permanents and locum tenens job in many specialties.

FOLLOW US

As a valued reader of NEJM, you are receiving this Weekend Briefing because you selected to receive the NEJM Weekly Table of Contents. The Weekend Briefing is a companion to the Table of Contents. To ensure consistent delivery of NEJM emails, please add webm...@n.nejm.org to your Contacts or Address Book. Click here to unsubscribe from Weekend Briefing. If you prefer not to receive content alerts, information about updates, services, or special offers from NEJM.org, sign in to My NEJM Alerts to update your email preferences. The New England Journal of Medicine 860 Winter Street Waltham, MA 02451 USA Copyright © 2021 Massachusetts Medical Society. All rights reserved.

[NEJM]

View in browser

JJ LUNGZ MD SUBSCRIBE

Weekend Briefing January 30, 2021

  

IMAGES IN CLINICAL MEDICINE A 21-month-old boy presented with a pruritic rash on his left leg that was thought to be at the site of a recent insect bite. A video shows a pulsating erythematous plaque, referred to as Quincke’s sign, that was found on his leg. Read the article. VIEW MORE IMAGES »

To access the CME exam, look for the CME icon in the toolbar on the article page.

ORIGINAL ARTICLE

Cryoablation or Drug Therapy for Initial Treatment of Atrial Fibrillation CLINICAL PRACTICE Atrial Fibrillation

CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL

Case 3-2021: A 48-Year-Old Man with Transient Vision Loss FIND MORE CME »

IMAGES IN CLINICAL MEDICINE LEARN MORE »

PERSPECTIVE The NAM at 50: Vaccine Innovations — Past and Future J.L. Gerberding and B.F. Haynes Remarkable progress has been made by the use of vaccines. The future holds great promise for vaccine-mediated control of global pathogens, but providing affordable access to effective vaccines for everyone who could benefit from them remains an important challenge. Read the article.

FACEBOOK Duration of Culturable SARS-CoV-2 in Hospitalized Patients with Covid-19 TWITTER Monoclonal Antibodies to Disrupt Progression of Early Covid-19 Infection INSTAGRAM Last-Mile Logistics of Covid Vaccination — The Role of Health Care Organizations

ORIGINAL ARTICLE

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

F.P. Polack and Others

A vaccine containing an RNA molecule encoding the SARS-CoV-2 spike protein was tested in a trial in which two injections were given 3 weeks apart. After the second injection, Covid-19 developed in 162 patients receiving placebo, with a median follow-up of 2 months, and in 8 patients receiving the vaccine. Side effects were mainly mild-to-moderate injection-site pain and swelling. Read the article.

PERSPECTIVE At the Cusp — Reimagining Infective Endocarditis Care amid the Opioid Epidemic M.A. Incze

The opioid epidemic has transformed the epidemiology of infective endocarditis. Treatment models focused on managing acute complications could be expanded to encompass substance use disorder treatment, intensive case management, supportive housing, and primary care. Read the article.

LISTEN TO THE PODCAST »

Cryoablation for Initial Treatment of Atrial Fibrillation

Read the related article. VIEW ALL QUICK TAKES »

Read the related article. VIEW ALL VISUAL ABSTRACTS »

Physician Jobs January 30, 2021

[NEJM]

View in browser

JJ LUNGZ MD SUBSCRIBE

Weekend Briefing February 6, 2021

  

IMAGES IN CLINICAL MEDICINE A 17-year-old girl with systemic lupus erythematosus presented with decreased vision in her right eye. Examination of the fundus revealed combined occlusion of the central retinal artery and vein. Read the article. VIEW MORE IMAGES »

To access the CME exam, look for the CME icon in the toolbar on the article page.

ORIGINAL ARTICLE

Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine ORIGINAL ARTICLE A Cluster-Randomized Trial of Hydroxychloroquine for Prevention of Covid-19 INTERACTIVE MEDICAL CASE A Treacherous Course CLINICAL PROBLEM-SOLVING Hunting for a Diagnosis FIND MORE CME »

IMAGES IN CLINICAL MEDICINE LEARN MORE »

PERSPECTIVE A Shared Evaluation Platform for Medical Training J.F. McConville and J.N. Woodruff The debate about changing the scoring system for the USMLE Step 1 exam is both a manifestation of dysfunction in the medical education pathway and an opportunity to address this dysfunction. Read the article. PERSPECTIVE Learning How to Die — Lessons from the Irish Wake R.M. Olson Over years of rigorous medical training, from cold cadaver labs to physically demanding, gruesome codes, it gets easier to stop giving love so freely, to cover a dying person’s face, to put on your mask. Yet there are moments in medicine that crack our thick exteriors. Read the article.

FACEBOOK Levonorgestrel vs. Copper Intrauterine Devices for Emergency Contraception TWITTER Cryoballoon Ablation as Initial Therapy for Atrial Fibrillation INSTAGRAM Antigen Presentation by B Cells in Multiple Sclerosis

CORRESPONDENCE

Duration of Culturable SARS-CoV-2 in Hospitalized Patients with Covid-19

M.-C. Kim and Others In 21 consecutive patients with confirmed Covid-19, the median times from symptom onset to negative viral culture and negative real-time RT-PCR were 7 days and 34 days, respectively. The longest interval from symptom onset and from resolution of fever to positive culture was 12 days and 3 days, respectively. Read the article.

PERSPECTIVE Vaccine Innovations — Past and Future

J.L. Gerberding and B.F. Haynes

Remarkable progress has been made by the use of vaccines. The future holds great promise for vaccine-mediated control of global pathogens, but providing affordable access to effective vaccines for everyone who could benefit from them remains an important challenge. Read the article.

LISTEN TO THE PODCAST »

Efficacy and Safety of mRNA-1273 SARS-CoV-2 Vaccine

Read the related article. VIEW ALL QUICK TAKES »

Read the related article. VIEW ALL VISUAL ABSTRACTS »

Physician Jobs February 6, 2021 Obstetrics & Gynecology New York Seeking Family Planning physician for Suffolk County The Department of Obstetrics and Gynecology of Northwell Health and South Shore University Hospital is seeking a full-time Family Planning Physician to join a very active Obstetrics and Gynecologic program located in Suffolk County, New York.... Hematology/Oncology New York BC/BE Gynecologic Oncologist sought for Long Island practice The Northwell Health Department of Obstetrics & Gynecology is seeking a dynamic BC/BE Gynecologic Oncologist to join a highly reputable and growing practice on Long Island. This is an excellent opportunity to join a successful and growing practice.…

Looking for a new practice opportunity? View these jobs and other listings at NEJM CareerCenter. Search now for both permanents and locum tenens job in many specialties.

FOLLOW US

As a valued reader of NEJM, you are receiving this Weekend Briefing because you selected to receive the NEJM Weekly Table of Contents. The Weekend Briefing is a companion to the Table of Contents. To ensure consistent delivery of NEJM emails, please add webm...@n.nejm.org to your Contacts or Address Book. Click here to unsubscribe from Weekend Briefing. If you prefer not to receive content alerts, information about updates, services, or special offers from NEJM.org, sign in to My NEJM Alerts to update your email preferences. The New England Journal of Medicine 860 Winter Street Waltham, MA 02451 USA Copyright © 2021 Massachusetts Medical Society. All rights reserved.

[NEJM]

View in browser

JJ LUNGZ MD SUBSCRIBE

Weekend Briefing February 13, 2021

  

NEW! NEJM Knowledge+ Covid-19 Vaccine Training: What Every Clinician Needs to Know

Introducing Covid-19 Vaccine Training, a free CME course that covers the fundamentals of the Covid-19 vaccines and the practicalities of how they are used. Learn more>>

IMAGES IN CLINICAL MEDICINE A 37-year-old man presented with painful, thickened, and cracked skin on his fingertips, which was associated with weakness of the proximal hip and shoulder muscles. The dermatologic finding was consistent with “mechanic’s hands,” and a diagnosis of antisynthetase syndrome was made. Read the article. VIEW MORE IMAGES »

To access the CME exam, look for the CME icon in the toolbar on the article page.

ORIGINAL ARTICLE

Phase 3 Trials of Tirbanibulin Ointment for Actinic Keratosis ORIGINAL ARTICLE Randomized Trial of a Vaccine Regimen to Prevent Chronic HCV Infection

CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL

Case 4-2021: A 70-Year-Old Woman with Dyspnea on Exertion and Abnormal Findings on Chest Imaging FIND MORE CME »

IMAGES IN CLINICAL MEDICINE LEARN MORE »

PERSPECTIVE The FDA’s Experience with Covid-19 Antibody Tests J. Shuren and T. Stenzel Early in the pandemic, the FDA recognized that ensuring access to antibody tests could advance understanding of Covid-19 and help inform the national response. But it faced several challenges related to evaluating test performance and authorizing products. Read the article. PERSPECTIVE Breathe C.A. Colaianni, K. Knoper, and N. Koscal It’s Dr. C.’s first weekend taking call at her new hospital, only weeks after graduating from residency. Called in to “level” a patient with laryngeal cancer and a closing airway, she’s suddenly disorientingly aware that she’s in charge now. Does she have what it takes? Read the article.

FACEBOOK Management of Antithrombotic Therapy after Acute Coronary Syndromes TWITTER Once-Weekly Semaglutide in Adults with Overweight or Obesity INSTAGRAM Hunting for a Diagnosis

ORIGINAL ARTICLE

Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine

L.R. Baden and Others Two injections of mRNA-1273, a lipid nanoparticle–encapsulated mRNA-based vaccine produced in collaboration with the NIAID that encodes the SARS-CoV-2 spike protein, conferred protection against Covid-19 illness in 94% of vaccinated patients. Adverse effects of the vaccine were mild, transient local reactions, and the incidence of systemic effects such as fever, headache, and fatigue was low. Read the article.

PERSPECTIVE The Future of Drug-Pricing Transparency W.B. Feldman, B.N. Rome, J. Avorn, and A.S. Kesselheim A federal “Transparency in Coverage” rule requires insurers to disclose list prices and historical net prices for medications and to give patients personalized cost-sharing estimates. Despite industry opposition, the rule may endure under the Biden administration. Read the article. LISTEN TO THE PODCAST »

Incidence of SARS-CoV-2 Infection in Health Care Workers by Antibody Status

Read the related article. VIEW ALL QUICK TAKES »

Read the related article. VIEW ALL VISUAL ABSTRACTS »

Physician Jobs February 13, 2021

Obstetrics & Gynecology New York

Seeking a dynamic BC Gynecologist to join the Women’s Health Division The Department of Obstetrics and Gynecology of Northwell Health and The Zucker School of Medicine seek a dynamic Board-Certified Gynecologist to join the Women’s Health Division at John T. Mather Memorial Hospital in Port Jefferson, NY....

Hematology/Oncology New York BC/BE Gynecologic Oncologist sought for Long Island practice The Northwell Health Department of Obstetrics & Gynecology is seeking a dynamic BC/BE Gynecologic Oncologist to join a highly reputable and growing practice on Long Island. This is an excellent opportunity to join a successful and growing practice.… Looking for a new practice opportunity? View these jobs and other listings at NEJM CareerCenter. Search now for both permanents and locum tenens job in many specialties.

FOLLOW US

As a valued reader of NEJM, you are receiving this Weekend Briefing because you selected to receive the NEJM Weekly Table of Contents. The Weekend Briefing is a companion to the Table of Contents. To ensure consistent delivery of NEJM emails, please add webm...@n.nejm.org to your Contacts or Address Book. Click here to unsubscribe from Weekend Briefing. If you prefer not to receive content alerts, information about updates, services, or special offers from NEJM.org, sign in to My NEJM Alerts to update your email preferences. The New England Journal of Medicine 860 Winter Street Waltham, MA 02451 USA Copyright © 2021 Massachusetts Medical Society. All rights reserved.

[NEJM]

View in browser

JJ LUNGZ MD SUBSCRIBE

Weekend Briefing February 20, 2021

  

IMAGES IN CLINICAL MEDICINE A 56-year-old man presented with fever and shortness of breath. The white-cell count was 142,000 per microliter, and a diagnosis of acute monoblastic leukemia was made. Read the article. VIEW MORE IMAGES »

To access the CME exam, look for the CME icon in the toolbar on the article page.

ORIGINAL ARTICLE

Avacopan for the Treatment of ANCA-Associated Vasculitis ORIGINAL ARTICLE

Early High-Titer Plasma Therapy to Prevent Severe Covid-19 in Older Adults

CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL

Case 5-2021: A 68-Year-Old Man with Delirium and Renal Insufficiency FIND MORE CME »

IMAGES IN CLINICAL MEDICINE LEARN MORE »

PERSPECTIVE Telemedicine and Medical Licensure — Potential Paths for Reform A. Mehrotra, A. Nimgaonkar, and B. Richman The growth of telemedicine is seen by some physicians, academics, and policymakers as a silver lining of the Covid-19 pandemic. Congress is considering bills that would facilitate the use of telemedicine, and licensure reform could be an important step. Read the article.

FACEBOOK Circadian Mechanisms in Medicine TWITTER Delayed Second Dose versus Standard Regimen for Covid-19 Vaccination INSTAGRAM

The FDA’s Experience with Covid-19 Antibody Tests

ORIGINAL ARTICLE

Repurposed Antiviral Drugs for Covid-19 — Interim WHO Solidarity Trial Results WHO Solidarity Trial Consortium The authors report interim results of the WHO Solidarity trial of four repurposed antiviral drugs — remdesivir, hydroxychloroquine, lopinavir, and interferon beta-1a — in patients hospitalized with Covid-19. Effects on overall mortality, initiation of ventilation, and duration of hospital stay are compared. Read the article.

PERSPECTIVE Vaccinating Children against Covid-19 — The Lessons of Measles P. Klass and A.J. Ratner

As we consider vaccinating children against Covid-19, measles and measles vaccination campaigns may offer relevant insights about parents’ decisions; trust, access, and equity; education campaigns and vaccination mandates; and effects of disinformation. Read the article. LISTEN TO THE PODCAST »

Avacopan in ANCA-Associated Vasculitis

Read the related article. VIEW ALL QUICK TAKES »

Read the related article. VIEW ALL VISUAL ABSTRACTS »

Physician Jobs February 20, 2021

Obstetrics & Gynecology New York Seeking a dynamic BC Gynecologist to join the Women’s Health Division The Department of Obstetrics and Gynecology of Northwell Health and The Zucker School of Medicine seek a dynamic Board-Certified Gynecologist to join the Women’s Health Division at John T. Mather Memorial Hospital in Port Jefferson, NY....

Chiefs/Directors New York Director of Ambulatory Telepsychiatry on Long Island Northwell Health Department of Behavioral Health is recruiting a full-time board certified psychiatrist to be the Director of Ambulatory Telepsychiatry at our service line HQ (Long Island) and remote with some travel throughout Northwell’s footprint.…

Looking for a new practice opportunity? View these jobs and other listings at NEJM CareerCenter. Search now for both permanents and locum tenens job in many specialties.

FOLLOW US

As a valued reader of NEJM, you are receiving this Weekend Briefing because you selected to receive the NEJM Weekly Table of Contents. The Weekend Briefing is a companion to the Table of Contents. To ensure consistent delivery of NEJM emails, please add webm...@n.nejm.org to your Contacts or Address Book. Click here to unsubscribe from Weekend Briefing. If you prefer not to receive content alerts, information about updates, services, or special offers from NEJM.org, sign in to My NEJM Alerts to update your email preferences. The New England Journal of Medicine 860 Winter Street Waltham, MA 02451 USA Copyright © 2021 Massachusetts Medical Society. All rights reserved.

[NEJM]

View in browser

JJ LUNGZ MD SUBSCRIBE

Weekend Briefing February 27, 2021

  

IMAGES IN CLINICAL MEDICINE An 80-year-old man presented with abdominal bloating, constipation, and weight loss. A CT scan of the abdomen and pelvis showed a large cystic mass, and a diagnosis of a urachal mucinous cystic tumor was made. Read the article. VIEW MORE IMAGES »

To access the CME exam, look for the CME icon in the toolbar on the article page.

ORIGINAL ARTICLE

Dexamethasone in Hospitalized Patients with Covid-19 ORIGINAL ARTICLE Muscarinic Cholinergic Receptor Agonist and Peripheral Antagonist for Schizophrenia REVIEW ARTICLE β-Thalassemias FIND MORE CME »

IMAGES IN CLINICAL MEDICINE LEARN MORE »

PERSPECTIVE Conquering Atherosclerotic Cardiovascular Disease — 50 Years of Progress G.H. Gibbons, C.E. Seidman, and E.J. Topol Substantial reductions in cardiovascular mortality in the United States reflect the power of a system that catalyzes the integration of basic science, translational research, technological innovation, evidence-based public policy, and public health practice. Read the article. PERSPECTIVE Without Sanctuary S.M. Ogunwole I often reflect on how our society decides who deserves punishment and who deserves redemption. I think about grace, and how Black people get so little. And I think about the varied manifestations of Ms. A.’s pain — how no one, me included, offered her a sanctuary. Read the article.

FACEBOOK BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Mass Vaccination Setting TWITTER

Avacopan for the Treatment of ANCA-Associated Vasculitis

INSTAGRAM

A Randomized Trial of Convalescent Plasma in Covid-19 Severe Pneumonia

REVIEW ARTICLE

Maintaining Safety with SARS-CoV-2 Vaccines M.C. Castells and E.J. Phillips

The vast majority of people who have received the Covid-19 vaccine to date have had self-limited local or low-grade systemic reactions that resolve within 2 or 3 days. A very small number of people have had serious anaphylactic reactions requiring catecholamine infusion and respiratory support. It is important to survey patients in advance of vaccination for allergic responses and to be aware of the early signs of an immediate hypersensitivity reaction. Read the article.

PERSPECTIVE Last-Mile Logistics of Covid Vaccination — The Role of Health Care Organizations T.H. Lee and A.H. Chen

In the United States, where public–private health care integration is highly variable, patients have turned to their health care providers for information about Covid vaccination, and health care systems are having to master four types of new and unfamiliar work. Read the article. LISTEN TO THE PODCAST »

Dexamethasone and Covid-19

Read the related article. VIEW ALL QUICK TAKES »

Read the related article. VIEW ALL VISUAL ABSTRACTS »

Physician Jobs February 27, 2021

[NEJM]

View in browser

JJ LUNGZ MD SUBSCRIBE

Weekend Briefing March 6, 2021

  

IMAGES IN CLINICAL MEDICINE Respiratory distress developed in a neonate after delivery at 32 weeks of gestation. Endotracheal intubation was unsuccessful, and he died 4 hours after delivery. A postmortem esophagram obtained after the administration of barium showed tracheal agenesis and bronchoesophageal fistula. Read the article. VIEW MORE IMAGES »

To access the CME exam, look for the CME icon in the toolbar on the article page.

ORIGINAL ARTICLE

Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19 ORIGINAL ARTICLE A Randomized Trial of Albumin Infusions in Hospitalized Patients with Cirrhosis REVIEW ARTICLE Diffuse Large B-Cell Lymphoma FIND MORE CME »

IMAGES IN CLINICAL MEDICINE LEARN MORE »

PERSPECTIVE Establishing Equity in Medical Education — Supporting Clinical Trainees with Disabilities S. Rastogi No road map exists to help medical students with disabilities navigate the wards, and supervisors may challenge students’ accommodations or fail to brief their colleagues on students’ needs. Systemic change is needed to dismantle these barriers in medical training. Read the article. PERSPECTIVE Physician, Heal Thy Double Stigma — Doctors with Mental Illness and Structural Barriers to Disclosure O.S. Haque, M.A. Stein, and A. Marvit Throughout the medical school admissions process, training, and licensure activities, students and physicians with histories of mental illness face structural barriers that result in discrimination and discourage disclosure and care seeking. Read the article. PERSPECTIVE Breathless S. Carter Mr. C. was one of those patients I thought about day in and day out. I desperately wanted him to get better, but it grew increasingly clear, with his pulmonary function not improving and other organ systems declining, that he was unlikely to have a meaningful survival. Read the article.

FACEBOOK Delayed Large Local Reactions to mRNA-1273 Vaccine against SARS-CoV-2 TWITTER STING-Induced Inflammation — A Novel Therapeutic Target in ALS? INSTAGRAM β-Thalassemias

ORIGINAL ARTICLE

Dexamethasone in Hospitalized Patients with Covid-19

The RECOVERY Collaborative Group

Among hospitalized patients with Covid-19, treatment with dexamethasone resulted in lower 28-day mortality than usual care, according to the level of respiratory support the patients were receiving, indicating a possible correlation between efficacy and the stage of infection. Read the article.

PERSPECTIVE Conquering Atherosclerotic Cardiovascular Disease — 50 Years of Progress

G.H. Gibbons, C.E. Seidman, and E.J. Topol

Substantial reductions in cardiovascular mortality in the United States reflect the power of a system that catalyzes the integration of basic science, translational research, technological innovation, evidence-based public policy, and public health practice. Read the article.

LISTEN TO THE PODCAST »

Albumin Infusions in Hospitalized Patients with Cirrhosis

Read the related article. VIEW ALL QUICK TAKES »

Read the related article. VIEW ALL VISUAL ABSTRACTS »

Physician Jobs March 6, 2021 Gastroenterology New York General Gastroenterologist opening in Upper Manhattan The ColumbiaDoctors Division of Digestive Diseases, has an opening for a general Gastroenterologist in Upper Manhattan. This position is open to both new graduates and experienced Gastroenterologists. NewYork-Presbyterian Allen Hospital is located on the northern tip of Manhattan.... Neurology New York BC/BE General Neurologist sought for Park Slope, Brooklyn opening The NewYork-Presbyterian Medical Group is looking for a full-time Board Certified/Board Eligible General Neurologist with an interest in outpatient neurology to join our team at NewYork-Presbyterian/Brooklyn Methodist Hospital in Park Slope, Brooklyn.…

Looking for a new practice opportunity? View these jobs and other listings at NEJM CareerCenter. Search now for both permanents and locum tenens job in many specialties.

FOLLOW US

As a valued reader of NEJM, you are receiving this Weekend Briefing because you selected to receive the NEJM Weekly Table of Contents. The Weekend Briefing is a companion to the Table of Contents. To ensure consistent delivery of NEJM emails, please add webm...@n.nejm.org to your Contacts or Address Book. Click here to unsubscribe from Weekend Briefing. If you prefer not to receive content alerts, information about updates, services, or special offers from NEJM.org, sign in to My NEJM Alerts to update your email preferences. The New England Journal of Medicine 860 Winter Street Waltham, MA 02451 USA Copyright © 2021 Massachusetts Medical Society. All rights reserved.

[NEJM]

View in browser

JJ LUNGZ MD SUBSCRIBE

Weekend Briefing March 13, 2021

  

IMAGES IN CLINICAL MEDICINE A 36-year-old woman presented with cough and shortness of breath. A chest radiograph showed fine micronodular opacities. A transbronchial biopsy revealed microliths, and a diagnosis of pulmonary alveolar microlithiasis was made. Read the article. VIEW MORE IMAGES »

To access the CME exam, look for the CME icon in the toolbar on the article page.

ORIGINAL ARTICLE

A Pragmatic, Randomized Clinical Trial of Gestational Diabetes Screening CLINICAL PRACTICE Epistaxis

CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL

Case 7-2021: A 19-Year-Old Man with Shock, Multiple Organ Failure, and Rash FIND MORE CME »

IMAGES IN CLINICAL MEDICINE LEARN MORE »

PERSPECTIVE Private Equity and Physician Medical Practices — Navigating a Changing Ecosystem J.M. Zhu and D. Polsky In recent years, private-equity firms have emerged as influential players in the health care market, offering a lifeline to smaller groups needing a competitive edge. The growth of private-equity investment has generated intense interest in potential adverse effects. Read the article. PERSPECTIVE The Good Doctor — Jack Geiger, Social Justice, and U.S. Health Policy S. Rosenbaum and D.R. Hawkins, Jr. H. Jack Geiger, who died in December, left an indelible imprint on health equity and social justice as paramount elements of a national health policy. Above all, this imprint is found in the community health centers program, where medicine is an entry point into health. Read the article. PERSPECTIVE My Intern R.E. Leiter Bobby was an intern in our program, and when he and I worked on a team together, he became my intern, and I was his senior resident. By the end of a long, busy month, I was proud of the doctor Bobby had already become. And then one day he didn’t come into work. Read the article.

FACEBOOK Antibody Responses in Seropositive Persons after a Single Dose of SARS-CoV-2 mRNA Vaccine TWITTER

A Randomized Trial of Albumin Infusions in Hospitalized Patients with Cirrhosis

INSTAGRAM Without Sanctuary

CORRESPONDENCE

Delayed Large Local Reactions to mRNA-1273 Vaccine against SARS-CoV-2

K.G. Blumenthal and Others Delayed cutaneous reactions developed in 12 patients days after initial injection-related symptoms resolved. The reactions, some as severe as grade 3, resolved in a few days with local therapy, and all 12 patients received the second vaccination; 6 had no recurrence of the local reaction, 3 had similar reactions to the initial injection reaction, and 3 had milder reactions. Read the article.

PERSPECTIVE Establishing Equity in Medical Education — Supporting Clinical Trainees with Disabilities S. Rastogi

No road map exists to help medical students with disabilities navigate the wards, and supervisors may challenge students’ accommodations or fail to brief their colleagues on students’ needs. Systemic change is needed to dismantle these barriers in medical training. Read the article.

LISTEN TO THE PODCAST »

Risdiplam in Type 1 Spinal Muscular Atrophy

Read the related article. VIEW ALL QUICK TAKES »

Read the related article. VIEW ALL VISUAL ABSTRACTS »

Physician Jobs March 13, 2021

[NEJM]

View in browser

JJ LUNGZ MD SUBSCRIBE

Weekend Briefing March 20, 2021

  

IMAGES IN CLINICAL MEDICINE A 63-year-old woman presented with nodules on her arms that appeared several weeks after she had cut her hands while washing fish. Granulomas were observed on biopsy, and cultures grew Mycobacterium marinum. Read the article. VIEW MORE IMAGES »

To access the CME exam, look for the CME icon in the toolbar on the article page.

ORIGINAL ARTICLE

Once-Weekly Semaglutide in Adults with Overweight or Obesity REVIEW ARTICLE Extrahepatic Manifestations of Chronic HCV Infection

CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL

Case 8-2021: A 34-Year-Old Woman with Cholangiocarcinoma FIND MORE CME »

IMAGES IN CLINICAL MEDICINE LEARN MORE »

PERSPECTIVE On the Shoulders of Giants — From Jenner’s Cowpox to mRNA Covid Vaccines A. Desmond and P.A. Offit The FDA recently authorized two mRNA vaccines for the prevention of Covid-19. Clearance of this hurdle represents the most recent in a series of advances in the realm of viral vaccines, each building on the last and each with a compelling record of disease prevention. Read the article. PERSPECTIVE Addressing Workforce Diversity — A Quality-Improvement Framework L.S. Rotenstein, J.Y. Reede, and A.B. Jena Lack of workforce diversity in medicine has detrimental effects on patients and clinicians. The evolution of the modern quality movement represents a useful parallel for achieving a complicated goal like equitable representation in health care. Read the article. PERSPECTIVE The Good Fit — Why Medical Applicants’ Personal Statements Are Anything but Personal M.H. Silver Mental illness is so stigmatized that despite its disproportionate prevalence in the field I was entering, I had to pretend I’d never faced it. My personal statement was the first of many experiences that highlighted this discordance between self-care and patient care. Read the article.

FACEBOOK Epistaxis TWITTER Donanemab in Early Alzheimer’s Disease INSTAGRAM My Intern

CORRESPONDENCE Antibody Responses in Seropositive Persons after a Single Dose of SARS-CoV-2 mRNA Vaccine F. Krammer and Others Some persons who have recovered from Covid-19 have antibodies to the spike protein of SARS-CoV-2. In 43 such persons who had received a first mRNA vaccine dose, high levels of neutralizing antispike antibodies were produced — in many cases even higher than after a second dose in 67 persons without baseline antibodies to the virus. Systemic reactions were more common in those seropositive before vaccination. Read the article.

PERSPECTIVE Private Equity and Physician Medical Practices — Navigating a Changing Ecosystem

J.M. Zhu and D. Polsky

In recent years, private-equity firms have emerged as influential players in the health care market, offering a lifeline to smaller groups needing a competitive edge. The growth of private-equity investment has generated intense interest in potential adverse effects. Read the article.

LISTEN TO THE PODCAST »

Pegcetacoplan in Patients with PNH

Read the related article. VIEW ALL QUICK TAKES »

Read the related article. VIEW ALL VISUAL ABSTRACTS »

Physician Jobs March 20, 2021 Hematology/Oncology New York Opportunity for Hematologist/Oncologist specializing in breast in Cortlandt Manor Columbia University/Herbert Irving Comprehensive Cancer Center (CUMC/HICCC), an NCI-designated comprehensive Cancer Center, in partnership with ColumbiaDoctors and NewYork-Presbyterian Medical Group, is looking for a Hematologist/Oncologist specializing in breast to provide comprehensive cancer services.... Gastroenterology New York BC/BE gastroenterologist/hepatologist opening in Queens The Division of Digestive Diseases at NewYork-Presbyterian Medical Group/Queens is seeking a board-certified/board eligible gastroenterologist/hepatologist to join our growing division. NewYork-Presbyterian/Queens is the largest voluntary hospital in Queens and serves patients in a culturally and ethnically diverse area.…

Looking for a new practice opportunity? View these jobs and other listings at NEJM CareerCenter. Search now for both permanents and locum tenens job in many specialties.

FOLLOW US

As a valued reader of NEJM, you are receiving this Weekend Briefing because you selected to receive the NEJM Weekly Table of Contents. The Weekend Briefing is a companion to the Table of Contents. To ensure consistent delivery of NEJM emails, please add webm...@n.nejm.org to your Contacts or Address Book. Click here to unsubscribe from Weekend Briefing. If you prefer not to receive content alerts, information about updates, services, or special offers from NEJM.org, sign in to My NEJM Alerts to update your email preferences. The New England Journal of Medicine 860 Winter Street Waltham, MA 02451 USA Copyright © 2021 Massachusetts Medical Society. All rights reserved.

[NEJM]

View in browser

JJ LUNGZ MD SUBSCRIBE

Weekend Briefing March 27, 2021

IMAGES IN CLINICAL MEDICINE A 5-year-old girl presented with fever, sore throat, and pain with swallowing. Examination showed a strawberry tongue. A throat culture grew group A streptococcus. Read the article. VIEW MORE IMAGES »

To access the CME exam, look for the CME icon in the toolbar on the article page.

ORIGINAL ARTICLE

A Placebo-Controlled Trial of Subcutaneous Semaglutide in Nonalcoholic Steatohepatitis REVIEW ARTICLE Atopic Dermatitis

CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL

Case 9-2021: A 16-Year-Old Boy with Headache, Abdominal Pain, and Hypertension FIND MORE CME »

IMAGES IN CLINICAL MEDICINE LEARN MORE »

PERSPECTIVE Emerging Infectious Diseases — Learning from the Past and Looking to the Future C. Elias, J.N. Nkengasong, and F. Qadri Remarkable progress has been made in preventing deaths from infectious diseases. Now, attention could shift to focusing more resources on pandemic preparedness, including detecting and containing emerging zoonotic threats while they are localized and manageable. Read the article. PERSPECTIVE Ensuring That LGBTQI+ People Count — Collecting Data on Sexual Orientation, Gender Identity, and Intersex Status K.E. Baker, C.G. Streed, Jr., and L.E. Durso For every gap in health and well-being whose contours we have mapped, the widespread lack of comprehensive data collection means that many more disparities — and the policy and programmatic interventions that might address them — remain unknown. Read the article. PERSPECTIVE “To Mitigate the Afflictions of the Human Race” — The Legacy of Dr. Rebecca Crumpler P. Klass Rebecca Crumpler was the first Black woman to earn a medical degree in the United States. The book she published highlights that though she didn’t yet know about microbes, she saw other invisible presences hovering over the heads of patients who were poor or Black. Read the article.

FACEBOOK Extrahepatic Manifestations of Chronic HCV Infection TWITTER New SARS-CoV-2 Variants — Clinical, Public Health, and Vaccine Implications INSTAGRAM Obesity, Immunity, and Cancer

ORIGINAL ARTICLE Efficacy of the ChAdOx1 nCoV-19 Covid-19 Vaccine against the B.1.351 Variant S.A. Madhi and Others A double-blind randomized trial in South Africa documented poor efficacy of two doses of the ChAdOx1 nCoV-19 vaccine against the B.1.351 variant of SARS-CoV-2 that emerged in South Africa. Infections occurred in 3.2% of placebo recipients and in 2.5% of vaccine recipients. Thirty-nine of the 42 virus isolates were the B.1.351 variant. None of the cases led to hospitalization or death. Read the article.

PERSPECTIVE On the Shoulders of Giants — From Jenner’s Cowpox to mRNA Covid Vaccines

A. Desmond and P.A. Offit

The FDA recently authorized two mRNA vaccines for the prevention of Covid-19. Clearance of this hurdle represents the most recent in a series of advances in the realm of viral vaccines, each building on the last and each with a compelling record of disease prevention. Read the article.

LISTEN TO THE PODCAST »

Vaccine Efficacy of ALVAC-HIV (vCP2438) and Bivalent Subtype C gp120–MF59 in HIV-Uninfected Adults — HVTN 702

Read the related article. VIEW ALL QUICK TAKES »

Read the related article. VIEW ALL VISUAL ABSTRACTS »

Physician Jobs March 27, 2021

[NEJM]

View in browser

JJ LUNGZ MD SUBSCRIBE

Weekend Briefing April 3, 2021

IMAGES IN CLINICAL MEDICINE A 31-year-old man with newly diagnosed HIV infection presented with weight loss and papular skin lesions. A blood smear showed yeastlike organisms, and a diagnosis of talaromycosis was made. Read the article. VIEW MORE IMAGES »

To access the CME exam, look for the CME icon in the toolbar on the article page.

ORIGINAL ARTICLE

Adjuvant Nivolumab in Resected Esophageal or Gastroesophageal Junction Cancer ORIGINAL ARTICLE Trial of Upadacitinib and Adalimumab for Psoriatic Arthritis CLINICAL PRACTICE Glucose-Lowering Drugs to Reduce Cardiovascular Risk in Type 2 Diabetes INTERACTIVE MEDICAL CASE Casting a Wide Net FIND MORE CME »

IMAGES IN CLINICAL MEDICINE LEARN MORE »

PERSPECTIVE From Vaccine Nationalism to Vaccine Equity — Finding a Path Forward I.T. Katz, R. Weintraub, L.-G. Bekker, and A.M. Brandt To help meet the global need for Covid vaccination, the United States could create a program that integrates global health needs into ongoing funding priorities, augments funding for vaccine production and delivery, and assists in building critical health infrastructure. Read the article. PERSPECTIVE Vancomycin Infusion Reaction — Moving beyond “Red Man Syndrome” S. Alvarez-Arango and Others Although “red man” might, at first glance, be taken as a straightforward description of a white male patient with an erythematous skin reaction, the term had a ready referent outside medicine, where it had long carried racist connotations. Read the article. PERSPECTIVE Beyond the Rubble of Lake Street — Minds in Crisis in a City in Crisis R. Grossman-Kahn I know that psychotic symptoms may reflect current headlines, so I shouldn’t be surprised to see patients with symptoms related to George Floyd’s murder. But I am taken off guard, viewing a timely commitment to social justice through the lens of mental illness. Read the article.

FACEBOOK Atopic Dermatitis TWITTER Embracing Genetic Diversity to Improve Black Health INSTAGRAM

On the Shoulders of Giants — From Jenner’s Cowpox to mRNA Covid Vaccines

CORRESPONDENCE SARS-CoV-2 Infection after Vaccination in Health Care Workers in California J. Keehner and Others After more than 36,500 health care workers at the University of California received at least one dose of vaccine, 71% of 379 workers with positive SARS-CoV-2 tests had positive results within 2 weeks after the first dose. Of 37 workers with positive results after the second dose, 7 had positive results 15 or more days after the dose. Read the article.

PERSPECTIVE Emerging Infectious Diseases — Learning from the Past and Looking to the Future

C. Elias, J.N. Nkengasong, and F. Qadri

Remarkable progress has been made in preventing deaths from infectious diseases. Now, attention could shift to focusing more resources on pandemic preparedness, including detecting and containing emerging zoonotic threats while they are localized and manageable. Read the article.

LISTEN TO THE PODCAST »

Nivolumab in Esophageal or Gastroesophageal Junction Cancer

Read the related article. VIEW ALL QUICK TAKES »

Read the related article. VIEW ALL VISUAL ABSTRACTS »

Physician Jobs April 3, 2021 Hematology/Neurology Oregon Opening for BC/BE Neurologist in Medford clinic Providence Medical Group and the Providence Brain & Spine Institute are in search of a board-certified/board-eligible Neurologist to practice at Providence Medical Group's (PMG) well-established Medford Neurology clinic. This general Neurologist position will participate in the Providence Brain & Spine Institute.... Psychiatry Washington State Seeking innovative and motivated Psychiatrist in Spokane Providence Medical Group is seeking an innovative and motivated Psychiatrist to help develop an ambulatory Psychiatry program, the anchor for a Primary Care collaboration model. Grow and expand an integrated team-based care, collaborative health care model while working with an excellent multi-disciplinary team.…

Looking for a new practice opportunity? View these jobs and other listings at NEJM CareerCenter. Search now for both permanents and locum tenens job in many specialties.

FOLLOW US

As a valued reader of NEJM, you are receiving this Weekend Briefing because you selected to receive the NEJM Weekly Table of Contents. The Weekend Briefing is a companion to the Table of Contents. To ensure consistent delivery of NEJM emails, please add webm...@n.nejm.org to your Contacts or Address Book. Click here to unsubscribe from Weekend Briefing. If you prefer not to receive content alerts, information about updates, services, or special offers from NEJM.org, sign in to My NEJM Alerts to update your email preferences. The New England Journal of Medicine 860 Winter Street Waltham, MA 02451 USA Copyright © 2021 Massachusetts Medical Society. All rights reserved.

[NEJM]

View in browser

JJ LUNGZ MD SUBSCRIBE

Weekend Briefing April 10, 2021

IMAGES IN CLINICAL MEDICINE A 5-year-old girl presented with painful inguinal lymphadenopathy. Her parents had removed a tick from her umbilicus 6 weeks earlier. A diagnosis of ulceroglandular tularemia was made. Read the article. VIEW MORE IMAGES »

To access the CME exam, look for the CME icon in the toolbar on the article page.

ORIGINAL ARTICLE

Lenvatinib plus Pembrolizumab or Everolimus for Advanced Renal Cell Carcinoma REVIEW ARTICLE Vestibular Schwannomas

CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL

Case 10-2021: A 70-Year-Old Man with Depressed Mood, Unsteady Gait, and Urinary Incontinence FIND MORE CME »

IMAGES IN CLINICAL MEDICINE LEARN MORE »

PERSPECTIVE Remote Patient Monitoring — Overdue or Overused? K. Mecklai, N. Smith, A.D. Stern, and D.B. Kramer As the use of remote patient monitoring services grows — driven by health care limitations imposed by the Covid-19 pandemic — clinicians, payers, and patients face important questions regarding the volume, value, and appropriate use of this care model. Read the article. PERSPECTIVE Race, Policing, and History — Remembering the Freedom House Ambulance Service M.L. Edwards In the 1960s, Pittsburgh’s Freedom House Ambulance Service supplanted the police in a role in which they were not effective, reimagined the role of Black citizens in improving community health, and helped establish national standards for emergency medical care. Read the article.

FACEBOOK Antibody Persistence through 6 Months after the Second Dose of mRNA-1273 Vaccine for Covid-19 TWITTER Neutralization of SARS-CoV-2 Variants B.1.429 and B.1.351 INSTAGRAM Sotatercept for the Treatment of Pulmonary Arterial Hypertension

ORIGINAL ARTICLE

Adjuvant Nivolumab in Resected Esophageal or Gastroesophageal Junction Cancer

R.J. Kelly and Others

Adjuvant chemotherapy has not improved disease-free survival among patients with resected esophageal or gastroesophageal junction cancer. In this trial, after neoadjuvant chemoradiotherapy and resection, patients with residual disease were randomly assigned to receive nivolumab or placebo. Nivolumab doubled the median disease-free survival from 11.0 to 22.4 months. Read the article.

PERSPECTIVE From Vaccine Nationalism to Vaccine Equity — Finding a Path Forward

I.T. Katz, R. Weintraub, L.-G. Bekker, and A.M. Brandt

To help meet the global need for Covid vaccination, the United States could create a program that integrates global health needs into ongoing funding priorities, augments funding for vaccine production and delivery, and assists in building critical health infrastructure. Read the article.

LISTEN TO THE PODCAST »

Oxygenation Targets for Acute Hypoxemic Respiratory Failure

Read the related article. VIEW ALL QUICK TAKES »

Read the related article. VIEW ALL VISUAL ABSTRACTS »

Physician Jobs April 10, 2021 Neurology Washington State Seeking full-time Neurologists in Everett Outpatient Neurology near Seattle! Providence Medical Group is seeking full-time outpatient Neurologists to join our Neuroscience Institute. Work alongside highly skilled Neuroscience providers, and enjoy an unparalleled quality of life in the Pacific Northwest against the backdrop of the beautiful Cascade and Olympic mountain ranges.... Family Medicine New York Primary Care opportunity in Queens, NYC Become a full-time Primary Care physician and work with a comprehensive, multidisciplinary team in New York City to aid an at-risk patient population. In this role, you will join NYC Health + Hospitals in their mission to serve low-income and vulnerable New Yorkers who are recovering from the impacts of the COVID-19 pandemic.…

Looking for a new practice opportunity? View these jobs and other listings at NEJM CareerCenter. Search now for both permanents and locum tenens job in many specialties.

FOLLOW US

As a valued reader of NEJM, you are receiving this Weekend Briefing because you selected to receive the NEJM Weekly Table of Contents. The Weekend Briefing is a companion to the Table of Contents. To ensure consistent delivery of NEJM emails, please add webm...@n.nejm.org to your Contacts or Address Book. Click here to unsubscribe from Weekend Briefing. If you prefer not to receive content alerts, information about updates, services, or special offers from NEJM.org, sign in to My NEJM Alerts to update your email preferences. The New England Journal of Medicine 860 Winter Street Waltham, MA 02451 USA Copyright © 2021 Massachusetts Medical Society. All rights reserved.