how could I recognize the signal peptides, N-and C-turminals of a protein sequece

taus...@gmail.com

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Nov 19, 2006, 4:11:02 AM11/19/06

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Hi, everyone!
I would like to ask you a question about how to recognize the signal
peptides, N-and C-terminal sequences from a predicted protein sequence.

Best wishes.

iainiai

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Nov 22, 2006, 5:34:20 PM11/22/06

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Hi "Tauschii",
Sorry that it took so long for this post to go up. Google blocked it
for some reason, so I had to approve it. I'll leave this question to
the forum.....

-IainR

Timothy A Richmond

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Nov 22, 2006, 5:34:49 PM11/22/06

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Do a google search on SignalP. This will predicted signal peptides for
n-terminus. Not sure about c-terminus.
Tim

Lapointe, David

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Nov 27, 2006, 8:59:35 AM11/27/06

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SignalP is one program as well as Sigcleave from the EMBOSS suite
(http://emboss.sourceforge.net/apps/release/4.0/emboss/apps/sigcleave.ht
ml) which is a instance of the Von Heijne method
1. von Heijne, G. "A new method for predicting signal sequence cleavage
sites" Nucleic Acids Res.: 14:4683 (1986)
2. von Heijne, G. "Sequence Analysis in Molecular Biology: Treasure
Trove or Trivial Pursuit" (Acad. Press, (1987), 113-117)

David

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