ask about Pathway Commons labelling method

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Michael A

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Aug 21, 2023, 10:52:52 PM8/21/23
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Hello,
I want to ask about Pathway Commons labeling technique. In the picture result that i get, the pathway network has a tag called "Mechanism Interferon" and it has title called "negative regulation of type I interferon-mediated signaling pathway".

My question is:
1. How does Pathway Commons give the tag "Mechanism Interferon"? based on Pathway Commons paper in 2019, you said it's based on most frequent words. However, when i count the word manually, i see several words have same amount of frequent numbers such as "signaling" has 2 words and mechanism also has 2 words. How does Pathway Commons select those words if they have same amount of most frequent numbers?

2. Related to sentence "negative regulation of type I interferon-mediated signaling pathway", it's a GO name pathway and it does not even contain any gene list but why is this name mentioned in my pathway network? can you explain it to me how the labeling works?

3. Related to those questions, one of the authors in this paper is Gary D. Bader. I know his works and he published a paper in Nature protocol in 2019 called "Pathway enrichment analysis and visualization of omics data using g:Profiler, GSEA, Cytoscape and EnrichmentMap". My question is does Pathway Commons adapt his method in that paper for labeling the Pathway network?

That's all my questions. 

Thank you,

Michael
enrichment-network.png
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