As for loss of control, the field lacks studies that have addressed the question in a more direct and valid way. If tolerance can be (at least partly) reflected by an increase in the actual use of the mobile phone, it is necessary to emphasize this by longitudinal designs rather than cross-sectional self-report studies. Ultimately, it is not possible to assert any definitive conclusions regarding the existence of tolerance in individuals with PMPU unless neurobiological evidence (e.g., alteration/sensitization in specific cerebral circuitries) confirms it.
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