How nanopulse technology can kill off cancerous cells

[Michael J Robey]

Nanopulse Technology

Using very short, very powerful electric shocks, researchers are
developing a way to jolt cancer cells into committing suicide, or
healthy cells into healing wounds.

The technique involves blasting cells with nanopulses. These are high-
power electrical bolts that last a few billionths of a second. They
deliver millions of volts - enough to light up a city, but each burst
lasts much less than the blink of an eye.

Longer shocks blow a cell apart, but researchers have found that the
fleeting nanopulses leave the cell membrane unaffected while mixing up
its insides. Now they are working out how to vary the timing and
intensity of the shocks to make cells behave in specific ways.

We would like to state a more consistent theory of cancer that we came
up with, based on ten years of experience. The results are
fascinating, obtained after PAP IMI™ exposures, and after comparing
these results with other theories and methods .

The first assumption involves the most basic principle of physics,
which we have come to realize several years ago in association with
cancer. The assumption concerns the physical energy of the cell.

Energy in physics, as in the universe as a whole, is the most
fundamental and universal concept of cause and effect. This controls
every action in the cosmos, between a donor of the energy [the cause]
and a receptor of the energy [the result]. We may say, a biological
system with energy transformed from one form to another or given from
a donor to a receptor, is a living system. A biological system with
active metabolism and energy not given and taken between donors and
receptors (without metabolism) is a dead system. We state below an
extremely simple and fundamental principle for cancer in relation to
the physical energy condition of a cell.

Cancer , is a critically low state of energy within a cell and with a
critically low metabolism , in which the cell is being “trapped” for
various reasons. This critically low energy and metabolism state is
manifested by a low transmembrane potential (TMP) of 15 mvolts, which
causes a “chain ” of specific malfunctions for the cell, and a general
state of ischemia (low energy) for the organism . When a cell is in
this particular low energy/metabolism state and has below TMP of 15
mvolts that is responsible for cell metabolism (Nobel Laureate Albert
Szent-Gyorgyi, Cone and others). The extremely weak TMP of 15 mvolts
cell divides in two identical parts in an attempt to survive in
larger numbers as a species.

Cancer is also the most general phenomenon of missing cell energy ,
low metabolism and division in biological systems. It is a phenomenon
found in all forms of life, i.e., plants, animals and, we may even
say, in all living societies such as that of humans, animals, plants,
and various micro-organisms .

We may suggest that Cell Cloning, Meristomatic Culturing for plants
and Cancer, all have the same starting point in common for cell
proliferation, that is metabolic stress, or poor nutrition, long known
for cell cloning and meristomatic culturing for plants.

We demonstrate the above, with a common example taken from
agriculture, which is known to most farmers: Let us suppose that we
have two plants which we water every day. The plants stay healthy,
but as a result do not produce flowers or seeds, which would lead to
reproduction of the plant. If we deprive one of the plants of its
nutrition by halting the water supply, as a result you will find the
plant in a state of “stress”. This plant will then produce flowers
and seeds in order to multiply and thus survive as a species. This
result is due to an “instinct” or “survival program” deeply encoded in
its DNA by its creator. This is a general phenomenon of reproduction,
known for almost all plants .

The same holds true for advanced organisms which may secure food
fairly easier versus a primitive one, which strives every day for
food. Indeed a primitive organism is in a continuous state of stress
while finding food and energy. In order to counter this and overtake
its daily battle for food and survival as a species, it multiplies
very fast and in large numbers.

On the contrary, an advanced organism or animal multiplies
relatively very slowly, and in fewer numbers. For example, larger
animals such as elephants or humans multiply very slowly, in
comparison to a smaller animal such as a rabbit or a primitive
organism.

The same is true for a poor, versus a rich society. For example, in
poor couples of primitive societies we will find that they usually
have between five and eight children. In comparison, the couples in
rich societies tend to have one or two children.

Cancer environment, diffusion and metastasis: When a low energy
proliferating cell is found to be lacking the proper nutrition and
energy, many times this is so because it is surrounded by an adverse
environment. This environment can be an anaerobic (non-oxygenated)
one, which is limiting the “energy providing synthesis” of Na and O to
K. Shortage of nutrition and energy may also be due to the fact that
cells are adjacent or are surrounded by another tumor, or other low
energy cells with limited veins and arteries. When a tumor is
starving for energy and nutrition, the starvation is transmitted to
the neighbors. Obviously, adjacent cells will suffer for proper
oxygenation, nutrition and metabolism. Removing energy and nutrition
by a tumor from adjacent cells, may cause a similar shortage of energy
and nutrition, thus cancer diffusion and cancer metastasis to adjacent
cells.

We can say, proliferating cells in an energy crisis, cause a similar
“energy crisis” to nearby cells. In other words, the energy crisis of
a smaller area of cells, is diffused or extended to a broader area,
because of the most basic and fundamental principle of physics, the
principle of the conservation of energy and the principle of
conservation of matter.

This crisis of low energy is reflected in the following general
chain reactions and results :

· low transmembrane potential,

· increased accumulation of sodium ions inside the cell :
Hypernatremia

· increased water molecules attached to sodium molecules
inside the cell associated to hypernatremia

· inflammation;

· increased volume of the cell and osmotic pressure inside
the cell, damaging the cell membrane

· swelling

· thinning of the cell membrane

· cell division.

The above conditions further obstruct cell metabolism. When
transmembrane potential drops below 15 mvolts, it leads to cell
division and eventually causes cells to over populate. This enhances
and diffuses the existing energy crisis from the cells to the
system. The energy crisis is then extended and generalized for the
system as a whole with the characteristic of low energy and ischemia
for the system itself. We may say, that cells with low energy get into
a “panic” state of feverish multiplication in order to preserve their
species, following an inherent program encoded in the most
fundamental part - their DNA, for survival under the emergency of
severe conditions. More cells are produced inside the tumor, or more
cells are produced adjacent to the tumor which found naturally in a
low energy or impoverished environment, diffused from the expanding
prime energy crisis – the prime cancer. Newer cancer cells will lack
even more energy for the same reasons. So, we see naturally why the
tumor grows or diffuses to adjacent areas and tissues, a phenomenon
known as “cancer diffusion”, i.e., cancers ability to diffuse to
adjacent healthy cells and tissues which is particularly unexplained
today by medicine. Obviously, the more those “low energy” cells
multiply, more energy is needed in the organism as a whole to feed
the newborn cells. Therefore, the energy crisis and the cell
starvation continually expand, as does cancer.

The organism soon becomes a “poor society in a panic crisis
situation” as a whole, lacking even more energy. In such a case, more
and more cells will be in a “panic state” for nutrition and energy and
so, we see that cancer triumphantly metastasizes and generalizes. The
organism or person becomes thin, weak and ischemic, with the common
characteristic of loss of weight, low energy, and low nutrition
intake. Cancer then spreads and generalizes, with no way for the
organism or person to overcome this increasing need of energy and
nutrition.

Apparently, there is no way out of this “energy crisis” when many
more new cells appear, and the organism (or the person) dies. This is
more or less the macroscopic “scenario” of the cancer phenomenon.
This is of course omitting numerous details of the cell physiology,
and the details of how the organism gradually fails as a whole. The
reason for this is “over population of starving cells” and the
resulting expansion of this “energy crisis”.

As an indisputable example and confirmation of the above, we may
consider the modern technique of cloning living cells through genetic
engineering. The technique of cloning living cells consists of
forcing a newly fertilized cell (egg) to duplicate into more copies so
that one identical embryo develops. This technique simply reported in
the mass media consists of isolating a newly fertilized egg and
placing it in an environment of very low nutrition. This state of
starvation and obviously low energy causes it to divide into copies
in exact agreement to the ideas expressed above.

After a number of divisions into cell copies, biologists then remove
the cell copies and place them in an environment of proper nutrition
and energy, where an independent and self organized embryo develops.

In some of the latest work, Karl Schoenbach and Stephen Beebe of the
Center for Bioelectrics in Norfolk, Virginia, have shown that the
pulses can make blood platelets clump together in the first stages of
clotting. This is something that might ultimately accelerate wound
repair.
Cell shock

Biologists already treat cells with mild electric shocks in the
laboratory, a technique called electroporation. These shocks make
temporary punctures in cell membranes so that cells can be pumped full
of experimental genes or proteins.

Schoenbach and his colleagues were the first to recognise that you
could use high-power, brief shocks to manipulate cells in other ways.
Working with electrical engineers in the late 1990s, they discovered
that such pulses fry bacteria and sterilize contaminated water.

One of the most significant discoveries was that nanopulses make
mammalian cells commit suicide, rather than blowing them up. This is a
relatively gentle way of killing, because scavenger cells come and
swallow the debris. By contrast, long electric shocks explode cells
and liberate toxic molecules that cause inflammation and pain.

For this reason, researchers hope to use nanopulses to kill cancer
cells while leaving healthy tissue intact. Schoenbach's team has
already shown that the pulses can shrink mouse tumours by over 50%,
and is working on catheters or non-invasive ways to deliver the shocks
to the body.
Quite how nanopulses trigger cell suicide still leaves scientists
scratching their heads. One idea is that the shock flips molecules in
the cell membrane from the inside to the outside, which tells
surrounding cells of their imminent death. "It says 'get rid of me,'"
says Thomas Vernier, who is studying the technique at the University
of Southern California, Los Angeles.

However they work, the nanopulses are prompting a flurry of ideas for
their use. They might replace liposuction as a way to demolish
unwanted flab, or blast away the fatty plaques that cause heart
disease. "It is like asking what to do with a newborn baby," says
Weaver. "Our speculations probably will not pick up the most important
things.

Studies :
PAPPAS’ PHYSIOLOGY OFTHE CELL AND ITS ATOMIC ENERGY

A new pulsed electric field therapy for melanoma disrupts the tumor’s
blood supply and causes complete remission without recurrence - Karl
Schoenbach and Stephen Beebe of the Center for Bioelectrics in
Norfolk, Virginia

For more info on how the PAP IMI™ Nanopulse Generator can aid to
kill off cancerous cells : www.papimiuk.blogspot.com www.papimi.com