A diamond set platinum ring from the Tiffany Notes collection by Tiffany & Co. The ring displays "Tiffany & Co" script engraved around the front of the band 3 times, with 3 round brilliant cut diamonds set in-between totalling 0.03ct. The 3mm wide ring is a size K and has a gross weight of 4.17 grams.
Nitro Platinum, Where the freshness of orange blossoms and the combination of sugary and masculine notes bring strength and complexity together to give an extra touch of elegance.
Fragrance Notes:
Embark on an olfactory adventure with PLATINUM. This exhilarating fragrance captures the essence of the great outdoors and the thrill of exploration, making it the perfect companion for your journeys. The olfactive pyramid of PLATINUM is a symphony of invigorating top notes, including birch leaves, orange and bergamot, setting the stage for an uplifting ambiance. The heart notes blend muguet, cardamom and violet harmoniously, adding depth and allure. Finally, base notes of vetiver, cedarwood and amber provide a soothing and elegant finish, leaving a refined and enduring impression. Indulge in the captivating essence of PLATINUM, where refined notes harmonize with your vibrant spirit. Embrace the invigorating world of PLATINUM today.
Top Note: Bergamot, Orange and Birch Leaves
Its woody and aromatic fragrance evokes a raw masculine power that opens up with a citrus splash of Bergamot, Apple with the freshness of mint.
vCloud Suite 2018 Platinum is a software-only bundle that contains vRealize Suite 2018 and vSphere Platinum. See the vRealize Suite and vSphere Platinum release notes for information about what is new in these products.
While I agree with most of what you said, there are a few Ableton certified trainers that turned me on to Izotope Ozone (for Ableton), even though I have used PN for a few years now. Unless it's a really crappy version to begin with, don't let PN touch your tracks for the sake of the artists and all those engineers that mixed that record a certain way because that's how it's supposed to sound. Platinum Notes = Will never touch my files.Īs long as you use good versions of your tracks (all of mine are ripped into Apple Lossless, or are downloaded as 320 MP3s if I can't get a lossless format) then use Auto Gain in Traktor, watch your meters when loading a track and use the gain on the mixer to match, but please. You can google "Loudness war" and get tons upon tons of more information on this as well. Here's a great example and a few sites where you can read about the Loudness War. Gain is the only thing that I will ever use to match track volumes. It has the potential to kill the dynamics of a track, something that can not be fixed. This is why I will never allow a program to do this to my tracks. I understand the problem of tracks not being the same volume as each other, but are you going to have the possibility of hurting a track just to make it sound as loud as the next?
Dynamics give life to a track by giving it highs and lows. Basically, "loud sounds better" to the common person today and most people are wearing shitty Apple earbuds that have to compete with all the surrounding mass of sound, so people are mixing as loud as possible. Here's the problem, an algorithm can't actually hear anything.īasically, I see Platinum Notes helping lend in to something going on that we like to call in the audio engineering world as "The Loudness Wars". What you are doing with a program like Platinum notes is taking out those dynamics with compressors and several other things that some algorithm decided upon. If you remove these you are seriously effecting the intended sound of a track. Not to mention as long as you've got good rips of the tracks they area already mastered with proper dynamics and such that the song is intended to have. I also do not believe in anything that is basically "auto-mastering" a song, and quickly frankly, as I said before, just the concept scares me. I've been an audio engineer for many years, and I have not heard of a single legit engineer using Izotope Ozone for mastering. While Platinum Notes is using a legit mastering suite to perform it's function, it's using the cheapest mastering suite you can buy. There's the recording engineer, mixing engineer, and then the mastering engineer, that all did their tweaks to make that track sound the way it does, the way the artist wanted it to. While not as much in EDM, with most music, tracks have several engineers tweaking the sound a certain way because that's how the artist wants it to sound. I take very much pride in the fact that I have the highest quality rips from all of my CDs and vinyls. If it was a simple volume matching, it wouldn't be that bad, but there's so much more that it has the potential to ruin for me.
I recommend it, or at least another "keying" program for every DJ. So don't hesitate to run your WAVs through it, you'll only get better output as a result.Ok, first, let me say this first, I LOVE MiK and every track I have has been run through it. Improved dynamics for 494 out of 500 files "We bought 500 files from Beatport and ran them through Platinum Notes 4.0. We posted this on, and it's true for both MP3 and WAV files: But if you have high-res audio tracks going into PN, it has more leeway to improve them. If you put a low-quality radio rip into Platinum Notes, it's not really going to improve it dramatically. There's a saying "garbage in, garbage out", and that applies to audio processing. The consensus is that if you have really good source files (WAVs or uncompressed AIFFs), PN will do an even better job and make the output better. WAV files myself and we created Platinum Notes to work on them. Danny Hard wrote:I see, but I believe that Wave tracks bought on Beatport aren't supposed to be editted by Platinum Notes right?ĭanny, I use.
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THE recent circular addressed to the dealers in platinum by the Director of Materials in the Ministry of Munitions requiring them to make a return of the whole of the stock of this metal, its ores and residues, on their premises, and forbidding any trading without a permit under a heavy penalty, will cause no surprise to those scientific men who are cognisant of the situation. Indeed, it is to be regretted that this step has not been taken before. It is most unfortunate that this rare, and for many purposes indispensable, meta) has been allowed to be used for jewelry and purely ornamental purposes. Either silver or gold is much better adapted to the production of attractive ornaments and is more beautiful than the greyish-white of platinum, while, of course, neither has the high melting point, electrical resistance, and chemical refractory qualities which make platinum so valuable a metal both in science and in the arts. The normal annual world's output of this metal is about 300,000 troy ounces. This figure dropped in 1914 to 250,000 ounces in consequence of the outbreak of war. Russia produces 95 per cent, of the world's total, chiefly from the Ural placers. The crude platinum contains from 70 to 90 per cent, of this metal, but it is invariably alloyed with iron in considerable proportions and with varying amounts of the other metals of the platinum group. Colombia produces about 10,000 ounces, while the total output of other countries does not exceed 2000 ounces. It is obtained in the United States Mint in the electrolytic refining of gold and silver, but only in amounts of about 200 ounces per annum. A small amount is also recovered from the mud resulting from the electrolytic refining of copper. Considerable interest was aroused by the recent announcement that platinum had been discovered in the Lower Rhine region of Germany. No statements as to its possible commercial exploitation have as yet been forthcoming.
Chronic lymphocytic leukemia (CLL) cells can lose function of P53 and acquire resistance to standard chemotherapy. We found that expression P73, a member of the P53 family, could be induced in CLL cells following CD40-ligation via a c-abl dependent pathway. Induced expression of P73 was associated with re-acquired sensitivity to drugs commonly used treat this disease, such as Fludarabine monophosphate. Similar effects also were noted for CLL cells transduced with an adenovirus vector encoding P731. Prior studies found that P73 also can be induced in breast and colon cancer cell lines following treatment with platinum-based compounds, potentially accounting for the activity of this class of drugs. We hypothesized that treatment of CLL cells with such compound also could induce P73 and that such induced expression also might be associated with re-acquired sensitivity of P53-deficient CLL cells to standard anti-cancer drugs. We studied the mechanisms and effects of platinum-based compounds on CLL cells lacking functional p53. Studies were done with both the p3 dysfunctional pro-lymphocytic celline MEC-1 and with primary CLL cells that lacked functional P53. Treatment of MEC-1 cells with cisplatinum or oxaliplatin induced nuclear translocation of c-Abl in several hours, which was subsequently followed by expression of P73, and then its putative target genes, encoding Bid, p21 and Fas (CD95). Platinum-induced expression of these P73-target genes could be inhibited by co-treatment of the cells with the c-Abl inhibitor imatinib. Cisplatinum treatment of MEC-1 cells resulted in cell cycle arrest. Furthermore, cis-platinum treatment of MEC-1 cells or P53-deficient CLL cells synergized with Fas-mediated apoptosis, and importantly resulted in acquired sensitivity to the drug fludarabine monophosphate in vitro, apparently via a c-Abl dependent pathway. Purified p53 dysfunctional CLL cells obtained before and after 24 and 48 hrs of in vivo cisplatinum treatment revealed de novo expression of both P73 and Bid, illustrating induction of P73 at therapeutic dosages of cisplatin. This study indicates that platinum treatment of CLL cells induces c-Abl dependent expression of P73, which can enhance the sensitivity of P53-deficient CLL cells to drugs such as fludarabine monophosphate. These results provide additional incentive to investigate the activity of platinum-based chemotherapy regimens in patients with refractory disease who have CLL cells lacking functional P53, which currently are ongoing in Europe and the United States.
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