It depends on how you implement autocropping. If you cut away the
margin based on white space, then there is a possibility that
artifacts (spots, smudges, pencil marks) will cause autocropping to
not function properly. On the other hand, if you implement
autocropping based on the text width and height after finding the
center point, then the margins become irrelevant, but if the text size
varies inside a book then you may have to adjust the settings. You
could implement both methods and let the user decide which works best
for his particular book.
Apps like ebookdroid use the white space method which is not very
friendly to older scanned books that have all kinds of things in the
margins.