NetSci X c elegans talk

[Thomas Chesney]

Thought you might find this interesting.

The final presentation at the Net Sci X conference in Wroclaw was by Albert Laszlo Barabasi about control in networks and he talked about his new unpublished work on c elgans predictions made by his theory that have been tested by Petra Vertes at Cambridge.

There were two predictions, one that has been proven experimentally and the second has not because experimental methods are not yet fine enough.

In a nutshell the prediction that has been proven is that knocking out one neuron in a larvae will impact on movement but in an adult knocking out the same neuron will not.

The second prediction is about right hand v left hand neurons. The theory predicts that knocking out one will have an impact but not the other - Barabasi said it was not yet possible do this in a real worm.

Barabasi has published on network control in Science and has had one paper on c elegans in Science Communications (I think), and the paper with Vertes is currently being written up.

Will OpenWorm be able to be used for experiments on larvae versus adults, and left hand versus right hand neurons?

Thomas

[Stephen Larson]

Very interesting!  I have heard good things about Barabasi's blending of control theory with C. elegans work.  As a plug, we'll be talking about extremely relevant whole-brain imaging data this Friday in the next OpenWorm journal club... don't miss it!

https://plus.google.com/b/117948341754627144949/events/c11opqt00i45pb127mtbnphhj6o

With regards to larvae vs. left & right neurons -- these are things that modeling & simulation can get at.  Our last journal club was on a paper that made a prediction about an asymmetry they seemed to find in their modeling efforts.  

Best,

  Stephen

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