Yes, Vinf and Rho need to be consistent with the rest of your model.
When your distances are in m, your velocity should be in m/s. Density should be in kg/m^3.
The actuator disk needs V and rho to be able to take propeller thrust coefficient (CT), and dimensionalize it into thrust to the figure out the corresponding strength of the actuator disk (in terms of vorticity).
The GUI will let you specify the disk parameters in a variety of ways (say, T, rpm, eta), and V, rho will also be used when converting between those quantities to get what VSPAERO actually needs as input.
Rob