There's a bug when you use symmetry with propellers. You could duplicate (copy + paste) a single propeller geometry (using the Cut, Copy, Paste buttons in Geom Browser) and change the Y value to -Y as a workaround to create symmetric propellers. Would have to reverse the direction of rotation and adjust the phase angle of one of the props. See attached file.
Side note: Sometimes VSPAero reports 'the mesh is not closed' after completing the simulation. The window freezes and the viewer cannot be opened. Closing and restarting the OpenVSP window allows the VSPAero viewer to be opened without re-running the solver as the solutions are already written to file.
That second part of your query sounds like a geometry optimization problem. I don't think OpenVSP has that provision-at least not available for frontend users. You'll probably have to set it up using the OpenVSP python API in addition to an external optimization package like IPOPT.
Also, those CT values differ by two orders of magnitude. Are you sure you are using the right convention when computing CT and CP? Note that helicopter and propeller conventions are different.
Cibin