Have a look at the incidence parameter on the wing to get an idea of what it does. Also, google wing incidence angle.
As Rob describes, there are a lot of things that go into aircraft component orientation to achieve relatively flat and level flight at cruise. For example, the angle of attack could be in reference to the aircraft frame itself, meaning zero angle relative to the freestream of the aircraft fuselage. An occupant would not feel any upward aircraft pitch at this condition. Wings will typically have some incidence at the root and "washout" or twist to lessen the angle at the wing tip. It's also worth having a look at Roskam's equations for CL and CD, specifically what reference area was used. The dynamic pressure is provided.
As a baseline, you should match at least the camber of the 182 airfoils for the thin mode to work in VSPAERO. Then, I'd recommend incrementally adjusting the root incidence until you get 2650 lb of lift for the aircraft.
Is any of this still unclear?