You should go back through the Workshop videos and watch one of the presentations on the Wave Drag tool. I talk about the appropriate number of slices in those presentations, but you need the video version, not just the slides.
Due to the formulation of the wave drag tool, the drag will always increase as the number of slices is increased.
What you are seeing with 100 slices is too much. If you gradually increase the number of slices, you will see more reasonable behavior before things possibly go singular (as they appear to have for the 100 slices).
It is impossible to know how many slices you need without knowing your geometry.
Rob