Hi Gianluca
In general terms, you want to use every tool available to you to improve tracking, so generally yes you want to use mount-based periodic error correction PEC) in addition to guiding. *Any* properly configured guiding will likely help.
The confusion may be where some mounts have a mount-based PEC that does not play well with guiding. If you are one of the unlucky few in this circumstance, you are somewhat forced to choose between them. I don't recall the specifics here, but I believe there are some ioptron and/or mounts using EQMod that don't play well here. I may be mistaken and/or there are other mounts with the same issue. You will need to figure the answer out in a mount-specific forum, or via the manufacturer.
As a separate point, If you have a mount that plays well with guiding, and after mount-based PEC still has a large periodic error (it may not be the primary period, but is still regularly occuring, such as a 2x or 3x period), you can also use the predictive PEC (PPEC) algorithm in PHD to target that particular period. This one-two punch is a common strategy and can be effective
hth
Brian