I realize now my previous total lack of understanding of RS232, COM ports, USB, etc. Reading up I find that RS232 used have real, PORTS in the computer that were hard wired and so worked directly. Going to USB, the USB is not associated 1-1 with any port and so there must be software so that the device can capture the correct signals, therefore drivers. I had no idea that a cable required software, although I do recall that my 507 cable did, but i did not understand why.
After messing with this last night and reading more, I would say that you have hit the nail on the head about a missing driver. as PHD2 shows no COM ports available. As to the 507, I tried it before, but to the mount and not the HBX. On my old LX200 it plugs into the mount base. The new Meade requires the cable be plugged into the HBX (or so I understand). I tried the 507 cable plugged into the Guide port on the new mount and it did not work, but it could be something else. I might not have the driver for that cable installed and/or updated. I will check these options.
I have found Silicon labs has a driver called CP210x USB to UART. I'm trying that as I see that some cables online suggest it. My cable was from Amazon and checking back on it, they said it came with a disc, but did not. I have emailed the seller for info.
Anyway, we have isolated the problem and I have learned a lot (about computers - nothing to do with astronomy) so I should be able to find a solution.
Does anyone know if it makes any difference if I have more than one driver installed? I mean Prolific, Meade, Silabs, etc. I presume that USB and the device can sort it out.
Don