Hi Tim,
In general you have the right idea regarding the relative image scale of guiding-to-imaging. I don't see any problem using the smaller pixels.
However, it skips over the main point of using an OAG with a scope like yours: you will experience differential flexure when using a separate guidescope. It's not a question of 'if' but 'how much'.
The reason to go with an OAG on a scope with a focal length as long as yours is to avoid DF. That is what I'd recommend.
If you do consider OAG, look for a guide camera that is modern and sensitive. An f/8 RC scope tends to have a lot of falloff on the outer edges, so there's less signal for the OAG. Using a more sensitive guide camera, having a larger pickoff mirror for the OAG, and adjusting the gain higher can all help here
Brian