I use a powered USB 3.0 hub to connect my mount (iEQ-45), Canon 7Dii, and QHY5L-II. The powered hub is connected back to my laptop using a single 10m USB 3.0 active repeater cable into a USB 3.0 socket on my laptop, this has worked well for over a year now.
I used to use a pair of 10m USB 2 active repeater cables, one running a hub connecting the Canon camera and the mount the other the QYH guide camera only. I was also lucky enough to have two separate USB hubs (one USB 2 the other USB 3.0) on my laptop that were independent of each other. If I tried sharing anything with the USB 2 link used for the QHY camera it or the other devices failed regularly. The Canon camera and mount where quite happy to be connected vis the USB 2 hub into the USB 3.0 hub on the laptop, with the QHY guide camera connected into the USB 2 hub on the laptop. One thing that is not realised by many is that laptops have internal USB hubs and even when not sharing connections from devices back to the laptop they can be effectively sharing a single hub internal to the laptop, and if bandwidth is tight this can be a cause of failure. I don't know but have long suspected that the QHY cameras are bandwidth hogs at USB 2 speeds.
I find my USB 3.0 single cable solution works very well and now only have two cables from my house out to my mount in the garden, one for power the other being the USB 3.0 active repeater, much less to trip over :^))
USB 3.0 hub I use, I think it has now been superseded:
This powered hub appears to have the advantage of not grouping all its ports together so that connecting a USB 2 device down rates all other ports to USB 2 speeds, by using ports at each end of the hub I do appear to still get USB 3.0 performance from the Canon 7Dii which has a USB 3.0 connection while the QHY guide camera and mount work quite happily connected at the other end.
10m USB 3.0 active repeater cable
I did try an alternative active repeater cable that did not work well. Luckily I decided to try the configuration out during the day before trying to use it at night for imaging and found the other cable very unreliable in that sometimes the laptop could detect devices connected to the hub and other times not. I have learnt that not all USB devices and hubs are equal and spending more money is not always a guarantee of getting better quality.
Jim