Fwd: [Annotation] ligands, receptors, and signaling pathways

[Alan Ruttenberg]

Begin forwarded message:

From: Doug howe <dh...@cs.uoregon.edu>

Date: June 16, 2008 3:56:21 PM EDT

To: GO Annotation list <annot...@genome.stanford.edu>

Subject: [Annotation] ligands, receptors, and signaling pathways

Reply-To: dh...@cs.uoregon.edu

Is it correct to annotate receptors with signaling pathway terms?  For example if a BMP receptor mutant is shown to have reduced bmp signaling, should the receptor gene be annotated with the term 'BMP signaling pathway', or are receptors themselves not part of the pathway?  Ditto for ligands.

The current def of 'BMP signaling pathway' is: A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor."

This def makes it seem like the signaling pathway initiates with things downstream of (and excluding) the receptor itself?

Whatever the policy is on this, it might be a useful curatorial note to include on such terms so curators can see the info right in term browsers.

-- 

Doug Howe, Ph.D.

ZFIN Scientific Curator

Zebrafish Nomenclature Coordinator

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