Very hard to say without seeing the ontology, or at least a breakdown of axiom type, but one strategy we have found useful to isolate the high expressivity components into modules, perform DL reasoning (or even FOL) on these, assert the results, then import these (minus expressive axioms), and keep the core in something like EL that can be speedily reasoned over using Elk or rule-based reasoners. It's not guaranteed complete but a bit of pragmatic intuition goes a long way here.
Of course the other thing to try is just different reasoners. Elk is ubiquitous for large biological ontologies but there have been newer reasoners by the same group and others that reason over larger subsets of DL, or perform advanced modularization for you (MORE, Konklude, ...)
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I hadn't thought of trying other reasoners. I use SWRL a lot and at least with Protege Pellet seems to work the best. For example, I think some of the other reasoners don't support all the SWRL builtins. But it can't hurt to try some other ones out. Especially because I think whatever is causing the problem almost certainly has nothing to do with rules anyway. I think it has to do with datatypes that conflict or that over-write some of the standard RDF ones, but that's just a hunch. Thanks for the idea I'll try some different reasoners and see what happens.Michael
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Thanks, that was great feedback, I'll try your suggestions.
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