Newest OncoKB updates: May 19, 2023

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May 19, 2023, 5:33:42 PM5/19/23

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Dear OncoKB user,

Here are the latest OncoKB updates:

Updated therapeutic implications - new alterations with a level of evidence

Level	Gene	Mutation	Cancer Type	Drug(s)	Evidence
1	RARA	PML-RARA Fusion	Acute Promyelocytic Leukemia	Tretinoin	PMID: 1850498; FDA-approval (1995) of Tretinoin
				Arsenic Trioxide	PMID: 11559723; FDA-approval (2000) of Arsenic Trioxide
				Tretinoin + Arsenic Trioxide	PMID: 23841729; FDA-approval (2000) of Arsenic Trioxide + Tretinoin
2	ERBB2	Amplification	Biliary Tract Cancer	Trastuzumab + Pertuzumab	Inclusion in Biliary Tract Cancer NCCN guidelines (v2.2023)
R2	EGFR	L792H	Non-Small Cell Lung Cancer	Osimertinib	PMID: 28093244, 28625641, 29506987, 29857056, 34526717

Changed Annotation

Gene	Mutation	Cancer Type	Drug(s)	Previous Level	Current Level	Reason
ESR1	Oncogenic ligand-binding domain in-frame insertions or deletions	Breast Cancer	Elacestrant	3A	2	Inclusion in Breast Cancer NCCN guidelines (v4.2023)
KRAS	G12C	Pancreatic Adenocarcinoma	Adagrasib, Sotorasib	3A	2	Inclusion in Pancreatic Cancer NCCN guidelines (v1.2023)

Updated therapeutic implications - Removal of therapies for variants with a level of evidence

Gene	Mutation	Cancer Type	Current Level of Evidence	Drug(s) removed from OncoKB	Drug(s) remaining in OncoKB	Evidence
FGFR2	Fusions	Cholangiocarcinoma	1	Infigratinib	Pemigatinib, Futibatinib	Discontinuation of infigratinib
FGFR1	Amplification	Lung Squamous Cell Carcinoma	3A		Debio1347, Erdafitinib
FGFR1, FGFR2, FGFR3	Oncogenic Mutations	All Solid Tumors	4		Debio1347, Erdafitinib, AZD4547

As always, don’t hesitate to reach out if you have comments, questions or suggestions. We love to hear from you.

The OncoKB Team

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