Hi,
the current version of SimuLTE does not allow the communication between an application on the UE and an application at the eNodeB.
You can setup a connection with a remote host outside the LTE network, possibly coexisting with the D2D connection with another UE.
SimuLTE also allows you to dynamically switch the D2D communication from the direct link to the traditional infrastructure path and vice versa, according to either a best-CQI policy or your own policy. You can find some information about this in this paper:
Best regards.
Giovanni