Try to cd to the folder where OMNeT++ is installed and do source setenv from there.
Also, some of the Python modules are not included in the Python distribution and need to be installed manually. This can be done either with pip or through packages offered by MacPorts or Homebrew. Also, the omnet++ executables are not digitally signed with a key recognized by Apple. BigSur will complain the first time OMNeT++ tries to start one of its executables or load dynamic libraries and kill the installation process. You will need to keep the General tab in System Preferences —> Security & Privacy visible so you can click Accept each time this happens to add an exception for the executable/shared library in question.
I got it working on Big Sur with Intel processor, but in the end I ended up running it in a Ubuntu VM under Parallels. The reason is that I need to get several others people working on the same project and Ubuntu installation presents less challenges…
Regards,
Dragos