Max median normalization (MaxMedian)

18 views

Skip to first unread message

Chris Gonzales

unread,

Oct 29, 2024, 9:37:42 AM10/29/24

to Omics Playground

Where can I find a good reference for the Max median normalization?

Chris

Ivo Kwee

unread,

Nov 7, 2024, 4:05:21 AM11/7/24

to Omics Playground

Hi. MaxMedian is a variant of "median normalization", i.e. all medians per sample are equalized. But the medians in MaxMedian are set to the highest median of the samples. The rational is to have correction factors that are between [0,1] (or scaling factor above one [1,)) that can be used as QC. In similar vain, MaxSum is just "total intensity" normalization (sum of columns) and scaled to the maximum of the sums with similar reasoning.