"how we made Hotmail 10X faster"

[Holt]

Critical lessons here for the Developing World, where bandwidth is SLOW+EXPENSIVE:

Data represents 75th percentile measurements from hundreds of runs of an automated test against a production server. Bandwidth is 300kb down/75 kb up/150ms latency, and browser is IE9. Your results may vary.	Hotmail Dec ‘10	Hotmail June ‘11
Open message	3.3 seconds	0.18 seconds
Delete message	3.1 seconds	0.14 seconds
Compose new message	4.3 seconds	0.20 seconds

In short, use modern browsers and pre-cache users' most common needs:

http://windowsteamblog.com/windows_live/b/windowslive/archive/2011/06/30/instant-email-how-we-made-hotmail-10x-faster.aspx

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