The quality of the reporting in the Owen 1990 study was low, and this study does not meet the current expected standards (Schultz 2010). No conclusions can be drawn from this study due to the small number of participants and risk of bias. Owen 1990 was rated as high risk of bias for blinding of participants and personnel. The study was rated as unknown risk of bias for the other assessed items. The exact details of the medication prescribed in the usual care arm, in terms of dosage and frequency were not reported.
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