Yes. You have at last 3 ways:
1. Simplest way is convert you game to node module or to browser plugin (NPAPI or/and PPAPI).
2. It is not best solution, but it possible to run nwjs in hidden window and render there your gui, then via sockets (or via process memory OS API) send rendered picture into the game process and there render it over game image.
3. Integrate nwjs into the game or integrate game into nwjs.