As was said before, nitrous oxide with a B12 deficiency pre-existing, causes diseases such as fatigue, dementia etc syndromes and spinal nerve damage

[Joseph Arabasz MD]

Subject: As was said before, nitrous oxide with a B12 deficiency pre-existing, causes diseases such as fatigue, dementia etc syndromes and spinal nerve damage

 

Dear Topica et al,

                                        I hope this note finds You well

     The impression is that some characters knew about the dangers of nitrous oxide gas before it was reported at the Medical Literature

This material is from the 1990's

Cordially,

Joseph W Arabasz MD
S/P USAF, Top Secret 1964-69
University of Colorado at Boulder 1972, CU School of Medicine '75, '77, '83
Past Division Chairman, Anesthesiology, Cook County Hospital, Chicago, Illinois
Past Chairman, Respiratory Therapy, Cook County Hospital, Chicago
Diplomate ABA
Mensa
Sigma Xi, The Professional Science Research Society
< http://www.SigmaXi.org >
PO Box 6939
Denver, CO 80206

USA
https://groups.google.com/forum/#!categories/nutrition-jwamd
http://groups.google.com/group/nutrition-jwamd/topics
http://www.topica.com/lists/joseph...@topica.com (2001-2014 site closed/open)

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http://onlinelibrary

"A contraindication to nitrous oxide"

Southampton General Hospital, Southampton SO16 6XY, UK

First published: March 1999
DOI: 10.1046/j.1365-2044.1999.0811w.xView/save citation

Nitrous oxide is a widely used, safe, anaesthetic without adverse effects in routine clinical use. However, patients who have a pre-existing vitamin B12 or folate abnormality, whether inherited or acquired, are at particular risk of nitrous oxide toxicity [1]. This was brought to my attention when asked to anaesthetise a patient with the extremely rare disorder, dihydropteridine reductase (DHPR) deficiency. This is a rare inherited disorder of pterin metabolism and defective folate metabolism is an important feature. It is suggested that in patients with DHPR deficiency, accumulating dihydropterins (BH2) inhibit the enzymes important for folate turnover, and thus render the patient folate deplete [2].
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Regarding the nitrous oxide-Essential Vitamine B12 deficiencies, some would say that because of the damage to the myelin, it could be described as a nerve gas

     The worst case scenarios are when the Patient is deficient of B12 prior to the nitrous exposure, since when the methionine synthase enzyme is blocked, then the scavenging pathway is shut down for that cobalamin pathway (B12)

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