Updated New migraine treatment- Nicotinic Acid vasodilates & endocrinopathy fatigue seen with lactose intolerance

19 views
Skip to first unread message

Joseph Arabasz MD

unread,
Feb 6, 2020, 6:31:06 PM2/6/20
to nutriti...@googlegroups.com
Subject: Updated New migraine treatment- Nicotinic Acid vasodilates and endocrinopathy fatigue seen with lactose intolerance
 

     Details regarding types of Niacin, as different entities are labelled as Vitamine B3, but only Nicotinic Acid vasodilates to prevent migraines when taken immediately with the onset of the aura

Imperative to use only the Niacin, Essential B3 Vitamine Nicotinic Acid, which causes the vasodilation of the skin, cerebral vasculature etc
     This is experienced as erythematous, itchy skin

Vasodilating the cerebral arteries is how the migraines are immediately terminated, most likely by relaxing vascular, arterial smooth muscle

     Some "niacin" preparations deliberately don't cause the slightly itchy, reddened skin vasodilation and won't prevent migraines, eg, nicotinamide and inositol, although they are labelled as Niacin

      Revenues for migraine monoclonal antibody treatments (erenumab prescription) are about $750/month with only 50% effectiveness for about 30% of Patients

     Nicotinic acid treatment of migraines costs only about $.30/tablet but must be started immediately with aura

     Recently heard of the most unusual case of a Person who has aura, but doesn't have headaches
He has severe Parkinson's disease

 Newly approved ubrelvy is only effective for active migraines ~19% of cases, depending on the dose, and might require over an hour to take effect
     "The list price for a dose of ubrelvy is $85

------------------------------------------------------------------------------------------------------------------------------------------------------------------
Dear Topica,
                                                                                                                                                                                            I hope this note finds You well

     Much gnashing of teeth by personnel who feel they are about to experience reduced revenues from their anti-migraine monoclonal antibody monthly treatments which are apparently only 50% effective with 30% of Patients

FYI-

     As you're aware, some scammers attempt to drive others to extreme (aka psy ops sensory overload sociopathy)


     Heard about the Chicago states attorney wise guy who threatened that he, "causes headaches, but doesn't get them" (downtown city hall meeting) who is now persona non grata


      Was surprised to have found the mr. jim f donaldson esq JD, or his doppelganger, at the ~2624 East 7th Ave Parkway, Denver, CO 80206 as some sort of parishoner

     And the Rumor is that mr. jim f donaldson esq JD is being excommunicated- should make it easier to terminate with extreme prejudice his gang of doppelgangers' sociopathy

     his gang members, etc  are ms. rice jd on the bench, nazi dr. hoffman md at cphp.org ($1200/hour scam despite having made payments to them for about a decade) and dr. mahoney md


FYI-

     Found some recent Research concepts which indicate that endocrinopathies occur when People avoid lactose foods for decades because of reduced lactase, eg decreased Thyroxine function with hypothyroid Patients

     That, of course, would worsen fatigue

https://en.wikipedia.org/wiki/Lactose_intolerance 
"The exact number of adults with lactose intolerance is unknown. One estimate puts the average at 65% of the global population"

     Milk contains all of the Essential Amino Acids
There aren't any Essential Proteins
     However, A Complete Protein contains all of the Essential Amino Acids
     eg, Milk is a Complete Protein

https://academic.oup.com/jcem/article/99/8/E1454/2537424  
Systematic Appraisal of Lactose Intolerance as Cause of Increased Need for Oral Thyroxine

     Difficult to say what the effect would be on the Normal Thyroid Patient- speculative opinion would be subclinical hypothyroidism


Best wishes always


Thank you for your assistance with this matter


Cordially,


Joseph W Arabasz MD
S/P USAF, Top Secret 1964-69
University of Colorado at Boulder 1972, CU School of Medicine '75, '77, '83
Past Division Chairman, Anesthesiology, Cook County Hospital, Chicago, Illinois 
Past Chairman, Respiratory Therapy, Cook County Hospital, Chicago
Diplomate ABA
Mensa
Sigma Xi, The Professional Science Research Society 
PO Box 6939
Denver, CO 80206
USA


------------------------------------------------------------------------------------------------------------------------

FYI-

     

New migraine treatment costs ~$7000/year- However vasodilation with OTC Niacin, is made about $.20/episode which seems to be effective, and doesn't require missing a day of work


---------------

"Since then (to keep things simple as possible), was surprised to see that a single tablet of Niaspan 750mg (or an over the counter sustained release Niacin tablet of the same size) taken immediately with the aura of a migraine would prevent the headache and restore visual defects, possibly by smooth muscle relaxation and the resulting vasodilation to combat the apparent clamping down of blood vessels (with eventual rapid release), which has been described as the etiology of the migraine headache
     Adding a single 100mg immediate release OTC Niacin tablet might be more efficacious with that regimen
----------------


Seems a bit expensive, compared to the efficacious Niaspan OTC extended release pill cost of about $.20
     Adding the rapid acting immediate release 100mg tab of Niacin probably would be even more efficacious

     Imperative to use only the Niacin, Essential B3 Vitamine Nicotinic Acid, which causes the vasodilation of the skin

Vasodilating the cerebral arteries is how the migraines are immediately terminated

     Some "niacin" preparations deliberately don't cause the slightly itchy, reddened skin vasodilation and won't prevent migraines, eg, nicotinamide and inositol

     Unusual Pearl- how there is a Parkinson's Patient here at Denver Colorado who is being considered for deep brain stimulation
His comment was that he has aura, but doesn't experience migraines
     
The drug's maker, Amgen, said U.S. list price is for the once monthly self-injection treatment will be $575 per month or $6,900 annually

The drug's maker, Amgen, said U.S. list price is for the once monthly self-injection treatment will be $575 per month or $6,900 annually


migraines without side effects
When other medications have failed, new injection treatment may help some patients with disabling headaches.
by Shamard Charles, MD / April 17, 2018 / 4:09 PM MDT / Updated May 18, 2018 / 5:30 AM MDT

Millions of Americans suffer from migraine headaches. A new class of drug, fully human monoclonal antibodies, may help to prevent the excruciating headaches without causing side effects. Milan Ilic Photographer / Shutterstock

The Food and Drug Administration approved a new migraine drug on Thursday.

Aimovig, known generically as erenumab, is the first drug in a new class of headache medicines. It's been shown to stop migraine headaches before they start.

The drug would be approved for patients who have tried other drugs and found no relief. In studies, it did not entirely prevent migraines, but reduced their frequency.

“Aimovig provides patients with a novel option for reducing the number of days with migraine,” said Dr. Eric Bastings, deputy director of the FDA's neurology products division.

“We need new treatments for this painful and often debilitating condition.”

FDA's approval means the drug may soon be available under prescription. It should also be paid for by health insurance.

The drug's maker, Amgen, said U.S. list price is for the once monthly self-injection treatment will be $575 per month or $6,900 annually.

“The price of Aimovig reflects the value it brings to patients and society, including the financial impact on sufferers, caregivers and employers, while also factoring in critical issues such as patient affordability, and fair and timely access,” Amgen said in a statement.

Erenumab the first in a new class of drugs that block calcitonin gene-related peptide (CGRP), a molecule that transmits migraine pain signals during an attack. It's a human monoclonal antibody -- a targeted immune system protein.

It's formulated as an injection to provide long-lasting protection.


New Drug Could Help Ease Pain of Migraines
FEB. 23, 201701:45
More than 39 million Americans suffer from migraine attacks, according to the Migraine Research Foundation. Of these, about 4 million have chronic migraine and suffer headaches for 10 to 14 days a month.

While some people are helped by low cost, over-the-counter drugs such as ibuprofen, others need prescription medications, such as sumatriptan and ergotamine, which constrict the blood vessels in the brain and can cause dizziness or nausea. Botox injections are also used to help ease migraines in some people.

But a large percentage of sufferers are not helped by anything.

"This is the first-ever mechanism specific migraine drug designed for prevention," said Dr. Peter Goadsby, professor of neurology at Kings College London and the University of California, San Francisco, who is a lead researcher on the drug. "This will change migraine treatment for those who don’t respond to conventional treatments."

Goadsby's team found that the drug reduced the average number of monthly migraine headaches by more than 50 percent for nearly half of study participants. After three months, patients treated with the human antibody were nearly three times more likely to have reduced their migraine days by 50 percent or more than those treated with placebo.

Participants of the study also had a greater average reduction in the number of days with headaches and the number of days they needed to take drugs to stop the migraines.

No patients taking erenumab stopped treatment due to adverse side effects, but the scientists noted that more research will needed to investigate if the benefits continue.

Malden, Massachusetts native Denise Desjardins, 58, with niece Madeline Salvitella suffered from migraine headaches for over 10 years particularly around her menstrual cycle, but found great relief after taking erenumab, a fully human monoclonal antibody drug that is showing great promise in migraine prevention

“I would land in bed for two to three days, four to five times a year,” said Desjardins. “These were in-your-bed, no-matter-what headaches.”

Her migraines became a daily misery after a bilateral mastectomy following a diagnosis of breast cancer. She was put on Imitrex, a popular migraine drug that helps to quiet overactive pain nerves in the brain, but it didn't help.

For about four years, Desjardins has been taking an erenumab injection once a month, without any side effects, as part of the study.

"I don't even think I get migraines anymore," said Desjardins

Botox injections may relieve migraine pain in children, adolescents
“I think having a treatment that is specifically invented to treat a disease that affects millions of people, makes this a big game changer,” said Dr. Dario Zagar, president of Associated Neurologists of Southern Connecticut.

Because other migraine medications were not developed for headache, their side effects limited how well patients could tolerate them.

“I think someone who gets migraines, will tell you they would do just about anything to reduce how frequently they're getting them — and if you told someone who was getting migraines two or three times a week that they would only get one (a week) or possibly none at all — they would be very happy,” said Zagar
 
&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&

£2.25 billion per year, calculated on the basis of 25 million lost days

£150 million per year, mostly from the costs of prescription drugs and visits. The expenditure on all headache disorders is estimated at £250 million per year

The financial burden of migraine on the is conservatively estimated at £3.42 billion per year. Including all headache disorders the cost rises to £5-7 billion annually

That is for the Country of about 68 Million Citizens- £3.42 billion per year
US Population is about 330 Million, which implies the financial burden of migraines is about £17 billion ($20.9 billion US) per year
------------------------------
RESULTS:
Mean [standard deviation] total annual cost of headache among people with chronic migraine ($8243 [$10,646]) was over three times that of episodic migraine ($2649 [$4634], P?<?.001). Participants with chronic migraine had significantly greater direct medical costs ($4943 [$6382]) and indirect (lost productivity) costs ($3300 [$6907]) than did participants with episodic migraine (direct, $1705 [$3591]; indirect, $943 [$2084]) (P?<?.001 for each). Unlike previous findings, direct medical costs constituted the majority of total headache-related costs for both chronic migraine (60.0%, $4943 of $8243) and episodic migraine (64.3%, $1705 of $2649) participants. A large portion of direct medical costs are attributable to pharmaceutical utilization among both chronic migraine (80%, $3925 of 4943) and episodic migraine (70%, $1196 of $1705) participants


&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&


Reply all
Reply to author
Forward
0 new messages