A long-lasting poison scavenger

6 views
Skip to first unread message

Joseph Arabasz MD

unread,
Jan 10, 2019, 1:19:44 AM1/10/19
to



DRUG DEVELOPMENT

A long-lasting poison scavenger

  1. Mattia Maroso

Nerve agents are neurotoxic compounds found in pesticides and chemical weapons. They act by blocking the transmission of nerve impulses to the muscles, and exposure can be fatal within minutes. Zhang et al. developed a nanoparticle-based bioscavenger that breaks down organophosphate nerve agents into innocuous compounds. Prophylactic treatment of rats and guinea pigs confirmed low immunogenicity and good biodistribution. Treated animals were protected from repeated exposure to the nerve agent sarin over 7 days. This nanoscavenger might thus help prevent nerve-agent poisoning in at-risk subjects.

Sci. Transl. Med  eaau7091 (2019)


---------------------------------------------------------------------------------------------------------------------------



Reply all
Reply to author
Forward
0 new messages