the post viral "encephalitis lethargica" fatigue syndromes of 1918 and covid possibly due to GPCR antibodies

[Joseph Arabasz MD]

Dear Topica,

https://www.ncbi.nlm.nih.gov/books/NBK556051/ 

"Cranial Nerve 1 (Olfactory)

The primary olfactory cortex interacts with a variety of cortical and limbic structures by sophisticated pathways that allow the smell to become integrated with memory, emotions, and taste.

At each nostril, human beings have 6 to 10 million olfactory sensory neurons distributed along a surface area of 2.5 cm^2.

(Some Hounds have almost 300 million olfactory sensory neurons)

These cells continuously regenerate from stem cells within the basal portion of the epithelium and have a partial replacement period of 30 to 40 days. The apical portion of these cells has dendrites that project into the epithelial surface, where they interact with odoriferous particles from the outside world by G protein-coupled receptors- (aka GPCR's)

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Comments have been that the 1918 viral epidemic with mortality rate worldwide of over 20 million had its own post "encephalitis lethargica" fatigue syndrome, possibly mediated by the same GPCR antibody mechanism

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