newest updated & donaldson obit- amprolium meal, meat etc additives, among others, are Thiamine anti-metabolites and apparently causes fatigue, brain fog spectrum of disease, &c
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Joseph Arabasz MD
Aug 3, 2025, 9:08:27 PMAug 3
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Subject: newest updated & donaldson obit- amprolium meal, meat etc additives, among others, are Thiamine anti-metabolites and apparently causes fatigue, brain fog spectrum of disease, &c
"Conclusions
It is the overall opinion of this commission that the benefits of antibacterial additives fed to Animals do not outweigh the risks.
the experience of post covid on top of the CFS (chronic fatigue syndrome- which is being worked up at Medical Clinic) was most unusual as nigerian 419 hustle bully conartist bragged that he caused that entity
European Food Safety Authority
EFSA Journal
EFSA J. 2021 Oct 26;19(10):e06854. doi: 10.2903/j.efsa.2021.6854
Maximum levels of contamination for dozens of antimicrobial active substances, feed.
Part 3- Amprolium
EFSA Panel on Biological Hazards (BIOHAZ)
FARSC - Feed Antimicrobial Resistance Selection Concentration
"Concentration (FARSC) study developed specifically for the assessment was applied. However, due to the lack of data on the parameters required to calculate the FARSC for amprolium, it was not possible to conclude the assessment. To address growth promotion,
data from scientific publications obtained from an extensive literature review were used. Levels of amprolium in feed that showed to have an effect on growth promotion/increased yield were reported.
The lack of antibacterial activity at clinically relevant concentrations for amprolium suggests that further studies relating to bacterial resistance are not a priority."
© 2021 European Food Safety Authority.
FYI-
Subject updated- amprolium meal, meat etc additives, among others, are Thiamine anti-metabolites and apparently causes fatigue, brain fog spectrum of disease, &c
amprolium fed food chain Animals, Agriculture
chicken
turkey
lamb
calves
meat
offal
Offal- aka variety meats, pluck or organ meats, is the internal organs of a butchered animal. Offal may also refer to the by-products of milled grains, such as corn or wheat (depending on context, there are several, dozens of types of offal)
eggs
ethanol yeast cultures
pet food- feline and canine
Subject- amprolium additives, among others which blocks the Essential B1 Thiamine metabolic pathway to cause disease among Humans
Doses from different sources of amprolium would be additive
"amprolium administered to laying hens is deposited primarily in the egg yolk, and residues can be detected in eggs for 10 days or more after cessation of treatment, depending on the dose and assay sensitivity."
"Be aware that the use of amprolium as an anticoccidial in lambs and calves has caused cerebrocortical lesions and clinical signs similar to those that occur with Thiamin deficiency."
There are several Thiamine antimetabolites, known since at least the 1930's-
Description
A thiamine antagonist due to its inhibition of thiamine pyrophosphorylation. It (pyrithiamine) is used to produce thiamine deficiency.
oxythiamine B1-hypovitaminosis- article
REF- B1-hypovitaminosis
oxythiamine B1-hypovitaminosis
Dear Topica,
I hope this note find You well
Apparently, certain rural groups are upset about the amprolium findings
FYI-
amprolium is type of Thiamine antimetabolite which blocks that Essential B1 Vitamine pathway and disrupts, prevents carbohydrate metabolism
caution-
amprolium, &c additives for poultry
Amprolium is the organic compound sold as anticoccidial against the protozoan, used in poultry, Animal grains
"Conclusions
It is the overall opinion of this commission that the benefits of antibacterial additives fed to Animals do not outweigh the risks.
With regard to medicinal substances, they are specifically used to prevent disease and therefore they should be treated as pharmaceutical specialties
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Some chicken grain contain amprolium (not an antibiotic)
Technologies and Risks
amprolium is structurally similar to vitamin B1. When it is administered orally to chickens, it has a minimal bioavailability, but the absorbed fraction is widely distributed into the tissues and rapidly eliminated in the urine and feces. Amprolium administered
to laying hens is deposited primarily in the egg yolk, and residues can be detected in eggs for ~ dozen days or more after cessation of treatment, depending on the dose and assay sensitivity.
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amprolium (antimetabolite of Thiamine)
subject area- Agricultural and Biological Sciences
Chapter- Visual System
amprolium
Be aware that the use of amprolium as an anticoccidial in lambs and calves has caused cerebrocortical lesions and clinical signs similar to those that occur with Thiamin deficiency.
blockage of the Thiamine metabolic pathway is perceived as severe deficiency of that Essential B1 Vitamine, or starvation causing Wernickes etc, apparently fatigue, hypoglycemia, &c
Impression is that Patients with the CFS (chronic fatigue syndrome), post covid should avoid amprolium from any source
As mentioned previously, there are some antimetabolites which block the Thiamine pathway, but don't reduce the serum level of that Essential B1 Vitamine
That implies it would be difficult to measure the Thiamine levels or if that pathway is open
Unusual that request to Lab to measure presence of any Thiamine antimetabolites wasn't answered
Amprolium - an overview | ScienceDirect Topics
www.sciencedirect.com › topics › medicine-and-dentistry › amprolium
It is a thiamine antagonist, blocking the thiamine receptors, thus preventing carbohydrate synthesis. It has a coccidiostatic effect at lower doses and ...
Chapter- Treatment and Drug Therapies of Coccidiosis in Carnivora
Thiamine Analogues
Amprolium (Amprol®, Amprolium®, Ampromed®, Amprosid®, Amprosol®, Amprovine®) is a quaternized derivative of pyrimidine that interferes with thiamine metabolism. It is a thiamine antagonist, blocking the thiamine receptors, thus preventing carbohydrate synthesis.
amprolium is defined as a thiamine analog inhibitor that is used as a coccidiostat for chicken feed, which could induce experimental disease
Chapter
Foods, Materials, Technologies and Risks
Amprolium is structurally similar to vitamin B1. When it is administered orally to chickens, it has minimal bioavailability, but the absorbed fraction is widely distributed into the tissues and rapidly eliminated in the urine and feces. Amprolium administered
to laying hens is deposited primarily in the egg yolk, and residues can be detected in eggs for ~ dozen days or more after cessation of treatment, depending on the dose and assay sensitivity.
No MRL has been established for this compound.
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MRL- Maximum Residue Limit
Agricultural and Biological Sciences
A maximum residue limit is defined as the maximum concentration of a compound residue that is allowed in or on a food commodity at a specific stage in the harvesting, storage, transport, marketing, or processing of the food, up to the final point of consumption.
fatigue:depression::dementia:psychosis
Most surprising was the apparent ruse by someone with real estate relations to travel the caribbean for vacations yearly, where the apparent non-specific tropical enteropathy malabsorption syndrome started and then possibly worsened by the gargoyle mr.
james frederick donaldson esq jd chef doppelganger's apparently sickening meal
FYI-
Obituary
mr. james frederick donaldson esq jd (1953-2017) was Rumored apparent moose mason, mormon (aka LDS), hitman conartist, (whose gargoyle doppelganger, at the lofts apts entrance, attempted to recruit & scammed at 11:35pm December 6, 2023, bragging that he had
used his confidence game, possibly kraut type, freud scam sociopathy for many dozens of generations at this Country)
he, or his doppelganger, was originally, apparently scamming as the hospital kitchen worker, then again later at the masonic consistory luncheon, ~1994 or the year after, where disease was immediately caused, and years later at the Denver restaurant where
that apparent stalker type doppelganger confessed to using gas toxins
Rumor is that the mr. james f donaldson esq jd doppelganger gang's management style has caused the National debt of $35+ Trillion
(Have seen several apparent doppelgangers of that ilk, most recently possibly the large mr. connor probst employee threatening false arrest at the Cherry Creek North bank 80206, if don't cooperate with the amputee customer and female teller, Mary, scams,
which have always avoided)
Disbarred 8951
936 E 18TH AVE
Denver, CO 80218-1003
BORN- January 11, 1953
DIED- August 27, 201
Deceased Name- donaldson, james frederick
Denver Post August 29, 2017
donaldson, james frederick
01/11/1953-08/27/2017 Survived by spouse, Deidra, etc
Services- Thursday, August 31, 2017 at mormon Church of Jesus Christ, 740 H Street, Denver 80220
Published by Denver Post from Aug. 29 to Aug. 31, 2017
Best wishes always
Thank You for Your assistance with this matter
Cordially,
Joseph Walter Arabasz MD
S/P USAF, Top Secret 1964-69
University of Colorado at Boulder 1972, CU School of Medicine '75, '77, '83
Critical Care Fellowship
Past Division Chairman, Anesthesiology, Cook County Hospital, Chicago, Illinois
Past Chairman, Respiratory Therapy, Cook County Hospital, Chicago
Diplomate ABA
Mensa
Sigma Xi, The Professional Science Research Society
PO Box 6939
Denver, CO 80206
USA
http://www.topica.com/lists/joseph...@topica.com (2001-2014 site, open-closed)
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7.3 Toxicological aspects
Coccidiostats are generally considered to be free from side effects and
toxicity as long as they are used in their target species at the correct dosage.
However, chemotherapeutic coccidiostats have a narrow range of safety and
there are many reports in the literature of accidental intoxications with
various anticoccidial drugs. However, most such events can be avoided if
proper manufacturing practices (GMP) are maintained.
Intoxications with coccidiostats have been reported with
poor mixing of the grain resulting in uneven cocccidiostat concentration,
failure to properly dilute the coccidiostat concentrate, and in cases of
incorrect identification of the product (Szancer, 1989; Novilla,
1992). The feed can become cross-contaminated at the production mill and
Animal meal has on occasion been shown to contain traces of coccidiostat.
Toxicity has also been noted when giving poultry meal
containing coccidiostat to animal species for which the feed was not intended
Diagnosis of coccidiostat intoxication is sometimes difficult due to
reversibility of clinical signs and/or the variability of pathological lesions
found with toxicity of coccidiostats of different chemical groups. Feed
analysis is often not possible to perform because the feed has already been
consumed
7.3.3 Residues
To avoid residues of coccidiostats in meat, withdrawal periods before
slaughter of the animals are assigned (table 7.I.). Eggs are, however, a
special problem. Maximum age levels and restrictions on usage in layer feed
may not always be enough to ensure that yolks are free of coccidiostats.
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"Comparison of the effects of some thiamine analogues upon thiamine transport through the BBB to the CNS (Central Nervous System)
A series of chemical analogues of thiamine were given to see how each affected the flux of thiamine into the brain and the findings are compared with those for a fifth analogue studied in previous work. Pyrithiamine, thiamine disulphide and acetylthiamine,
like amprolium, inhibited thiamine transport across the BBB
analysis shows that they compete mainly for the saturable component of thiamine flux across the BBB, with only a slight inhibition of the non-saturable component, most clearly seen with pyrithiamine.
oxythiamine, despite its similarity to thiamine did not have any significant effect upon the flux of the vitamin into the brain.
These findings explain the efficacy of pyrithiamine administration, especially in conjunction with a thiamine-deficient diet, in rapidly producing central neurological signs of deficiency.
(PREVIOUS STUDIES FROM THE 1930'S STATE THAT OXYTHIAMINE DOESN'T ENTER THE CNS (CENTRAL NERVOUS SYSTEM) CAUSING ONLY PERIPHERAL DISEASE, BUT PYRITHIAMINE DOES, CAUSING WERNICKES-
However, if the BBB is damaged by real Thiamine deficiency, previous administration of neopyrithiamine, etc, then oxythiamine would enter the CNS through the BBB and cause more serious disease-
oxymoronic scams are counterproductive)
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120223 6 15pm Should terminate phlebotomist sociopathy at urgent care, KP Aurora Center as she apparently deliberately caused problems with lab draw and needles
120223 5 24pm KP Aurora Center Lab and urgent care
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