hypoglycemia & migraine headaches

[Joseph Arabasz MD]

Subject- hypoglycemia & migraine headaches

 

Dear Topica et al,

hypoglycemia & migraine headaches

European Review Article 2022

"The role of brain glucose metabolism and the pathophysiology of migraine headache

The rationale for a brain energy deficit as cause for headaches (the “neuroenergetic hypothesis“ possibly could explain the migraine chronification) is presented.

The role of hypoglycemia as cause for migraine, both episodic and chronic, is discussed.

Abstract

Increasing evidence suggests that migraine may be the result of an impaired brain glucose metabolism. Several studies have reported brain mitochondrial dysfunction, impaired brain glucose metabolism in specific brain areas of migraineurs.

Furthermore, peripheral insulin resistance, a condition demonstrated in several studies, may extend to the brain, leading to brain insulin resistance. This condition has been proven to downregulate insulin receptors in neurons and triggers reduction in glucose uptake and glycogen synthesis, mainly during high metabolic demand.

This Review examines the clinical, epidemiologic and pathophysiologic data supporting the hypothesis that abnormalities in brain glucose metabolism may generate a mismatch between the brain's energy reserve and metabolic expenditure, which could trigger migraine attacks.

Moreover, alteration in glucose homeostasis could generate a chronic brain energy deficit promoting migraine chronification.

Best wishes always

Thank You for Your assistance with this matter

Cordially,

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