some gut bacteria could synthesize oxythiamine, the Thiamine anti-metabolite, and cause disease

[Joseph Arabasz MD]

Dear Topica,

                         I hope this note finds You well

     oxythiamine is an anti-metabolite which blocks the Essential B1 Vitamine Pathway

The body would perceive that as a severe Thiamine deficiency with all of its clinical presentations and complications

     The mortality rate from a severe Thiamine deficiency is 30%

"Therefore, it is

conceivable that other groups of bacteria can exist in the gut that can mediate the reverse

process and produce oxythiamine. An intriguing possibility may be that altered gut

microflora in ESRD can lead to abnormal oxythiamine production and absorption with

subsequent functional thiamine deficiency in the face of normal or increased serum levels"

      As has been reviewed, the text SILENCE, refers to the case where a Physician acquired a disease which was defined as non-curable, but after dialysis, disappeared

     The implication was that Dr North's original diagnosis was erroneous

"Even more unusual is the way North’s recovery occurred. She was one of the first people to be tried on renal dialysis"

     Should she have experienced gut bacteria which synthesized oxythiamine, which is dialyzable, or acquired that toxin from any source, eg some sort of fecalith there at the midwest, then she would have experienced a Thiamine deficiency because of that anti-metabolite

     fatigue:depression::dementia:psychosis

We are now aware that deficiencies of Thiamine (B1), Niacin (B3), Folate (B9), and/or Cobalamin (B12) cause severe fatigue and dementia, which is often misdiagnosed as depression or psychosis

     That would cause an expensive medical misadventure

     Rumor is that jonathan makes his living off medical misadventures

Best wishes always

Thank you for your assistance with this matter

Cordially,

Joseph W Arabasz MD

S/P USAF, Top Secret 1964-69

University of Colorado at Boulder 1972, CU School of Medicine '75, '77, '83

Past Division Chairman, Anesthesiology, Cook County Hospital, Chicago, Illinois

Past Chairman, Respiratory Therapy, Cook County Hospital, Chicago

Diplomate ABA

Mensa

Sigma Xi, The Professional Science Research Society

http://www.SigmaXi.org

PO Box 6939

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720-364-2265

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Subject Title- Thiamine deficiency in end-stage renal disease- malnutrition despite ample nutrients

"In another study, Koeth et al

found that intake of L-carnitine (in red meat) can cause atherosclerosis via a similar

mechanism. Therefore, these authors have identified gut microbiota as a link between

dietary intake of nutrients and CVD (cardiovascular disease). Furthermore, it is well-known that dietary and

environmental factors can lead to alterations in intestinal microbiome, thereby contributing

to the pathogenesis of various clinical phenotypes. In fact, Vaziri et al

evaluated the microbiota of patients with ESRD (end stage renal disease) on hemodialysis using phylogenetic microarray and found

significant differences in the abundance of numerous bacteria between the ESRD

and control groups. Furthermore, there is a report of a specific form of Escherichia coli

(“thiamine-missing” mutant E coli) that can convert oxythiamine to thiamine 9

 

Therefore, it is

conceivable that other groups of bacteria can exist in the gut that can mediate the reverse

process and produce oxythiamine. An intriguing possibility may be that altered gut

microflora in ESRD can lead to abnormal oxythiamine production and absorption with

Moradi and Said

Author manuscript; available in PMC 2017 July 20

subsequent functional thiamine deficiency in the face of normal or increased serum levels.

Although overt symptoms and signs of B1 deficiency might not be present, functional

thiamine deficiency may contribute to various complications of ESRD including oxidative

stress, impaired energy metabolism, anemia, CVD, and ultimately increased mortality

(Figure 1). These novel mechanisms will need to be further examined in future studies

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