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[公告] 博士論文口試 王翔昱 (2013/11/7)
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ぃ熬み~
Oct 31, 2013, 3:36:17 AM10/31/13
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清華大學資訊工程學系博士學位口試
學生姓名： 王翔昱
指導教授： 唐傳義 老師
指導委員：
口試委員： 韓永楷 老師、盧錦隆 老師、林俊淵 老師、葉信宏 老師
日期時間： 民國 102 年 11 月 07 日 13 時 30 分
口試地點： 清華大學台達館 629 會議室
口試題目： Application of Motif-Based Tools on Evolutionary Analysis of Multipartite Single-Stranded DNA Viruses
相似短序列比對工具於多組分單鏈去氧核糖核酸病毒演化分析之應用
論文摘要：
Multipartite viruses contain more than one distinctive genome component, and the origin of multipartite viruses has been
suggested to evolve from a non-segmented wild-type virus. To explore whether recombination also plays a role in the
evolution of the genomes of multipartite viruses, we developed a systematic approach that employs motif-finding tools to
detect conserved motifs from divergent genomic regions and applies statistical approaches to select high-confidence
motifs. The information that this approach provides helps us understand the evolution of viruses. In this study, we
compared our motif-based strategy with current alignment-based recombination-detecting methods and applied our
methods to the analysis of multipartite single-stranded plant DNA viruses, including bipartite begomoviruses, Banana
bunchy top virus (BBTV) (consisting of 6 genome components) and Faba bean necrotic yellows virus (FBNYV) (consisting of
8 genome components). Our analysis revealed that recombination occurred between genome components in some
begomoviruses, BBTV and FBNYV. Our data also show that several unusual recombination events have contributed to the
evolution of BBTV genome components. We believe that similar approaches can be applied to resolve the evolutionary
history of other viruses.
主要著作：
1.Hsiang-Iu Wang, Chih-Hung Chang, Po-Heng Lin, Hui-Chuan Fu, Chuanyi Tang and Hsin-Hung Yeh,
“Application of Motif-based tools on evolutionary analysis of multipartite single-stranded DNA viruses”
PLoS one 2013, DOI 10.1371/journal.pone.0071565
2.Chih-Hung Chang, Hsiang-Iu Wang, Hsiang-Chia Lu, Cheng-En Chen, Hong-Hwa Chen, Hsin-Hung Yeh and Chuan Yi Tang,
“An efficient RNA interference screening strategy for gene functional analysis,”
BMC Genomics 2012, 13:491 doi:10.1186/1471-2164-13-491
3.Chen, C.E., Yeh, K.C., Wu, S.H., Wang, H.I. and Yeh, H.H.
“A vicilin-like seed storage protein, PAP85, is involved in Tobacco mosaic virus replication"
J. Virol. 2013 published ahead of print JVI00268-13R1.
4.Lu, H.C., Hsieh, M.H., Chen, C.E., Chen, H.H., Wang, H.I. and Yeh, H.H.
”A high-throughput virus-induced gene-silencing vector for screening transcription factors in virus-induced plant
defense response in orchid.”
Molecular Plant-Microbe Interactions 2012 25(6):738-746.
5.Lu, H.C.*, Chen, C.E.*, Tsai, M.H., Wang, H.I., Su, H.J. and Yeh, H.H.
“Cymbidium mosaic potexvirus isolate-dependent host movement systems reveal two movement control determinants and
the coat protein is the dominant”
Virology 2009 388, 147-159.
--
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[;32m◆ From: WillJor從allan.cs.nthu.edu.tw [m
學生姓名： 王翔昱
指導教授： 唐傳義 老師
指導委員：
口試委員： 韓永楷 老師、盧錦隆 老師、林俊淵 老師、葉信宏 老師
日期時間： 民國 102 年 11 月 07 日 13 時 30 分
口試地點： 清華大學台達館 629 會議室
口試題目： Application of Motif-Based Tools on Evolutionary Analysis of Multipartite Single-Stranded DNA Viruses
相似短序列比對工具於多組分單鏈去氧核糖核酸病毒演化分析之應用
論文摘要：
Multipartite viruses contain more than one distinctive genome component, and the origin of multipartite viruses has been
suggested to evolve from a non-segmented wild-type virus. To explore whether recombination also plays a role in the
evolution of the genomes of multipartite viruses, we developed a systematic approach that employs motif-finding tools to
detect conserved motifs from divergent genomic regions and applies statistical approaches to select high-confidence
motifs. The information that this approach provides helps us understand the evolution of viruses. In this study, we
compared our motif-based strategy with current alignment-based recombination-detecting methods and applied our
methods to the analysis of multipartite single-stranded plant DNA viruses, including bipartite begomoviruses, Banana
bunchy top virus (BBTV) (consisting of 6 genome components) and Faba bean necrotic yellows virus (FBNYV) (consisting of
8 genome components). Our analysis revealed that recombination occurred between genome components in some
begomoviruses, BBTV and FBNYV. Our data also show that several unusual recombination events have contributed to the
evolution of BBTV genome components. We believe that similar approaches can be applied to resolve the evolutionary
history of other viruses.
主要著作：
1.Hsiang-Iu Wang, Chih-Hung Chang, Po-Heng Lin, Hui-Chuan Fu, Chuanyi Tang and Hsin-Hung Yeh,
“Application of Motif-based tools on evolutionary analysis of multipartite single-stranded DNA viruses”
PLoS one 2013, DOI 10.1371/journal.pone.0071565
2.Chih-Hung Chang, Hsiang-Iu Wang, Hsiang-Chia Lu, Cheng-En Chen, Hong-Hwa Chen, Hsin-Hung Yeh and Chuan Yi Tang,
“An efficient RNA interference screening strategy for gene functional analysis,”
BMC Genomics 2012, 13:491 doi:10.1186/1471-2164-13-491
3.Chen, C.E., Yeh, K.C., Wu, S.H., Wang, H.I. and Yeh, H.H.
“A vicilin-like seed storage protein, PAP85, is involved in Tobacco mosaic virus replication"
J. Virol. 2013 published ahead of print JVI00268-13R1.
4.Lu, H.C., Hsieh, M.H., Chen, C.E., Chen, H.H., Wang, H.I. and Yeh, H.H.
”A high-throughput virus-induced gene-silencing vector for screening transcription factors in virus-induced plant
defense response in orchid.”
Molecular Plant-Microbe Interactions 2012 25(6):738-746.
5.Lu, H.C.*, Chen, C.E.*, Tsai, M.H., Wang, H.I., Su, H.J. and Yeh, H.H.
“Cymbidium mosaic potexvirus isolate-dependent host movement systems reveal two movement control determinants and
the coat protein is the dominant”
Virology 2009 388, 147-159.
--
[m [1m [;32;40m┌─│┌┌─┌─╮─┬┌─╮│ ┌─ [1;37mtelnet://imaple.tw [31m�[;30;41m�[m
[1m [32m├─││├─├┬╯ │├─││ ├─ [37m [32mIAS_EverTale [37m [31m�[;30;41m�[m
[1m┌ [42m└─ [;30;42m�[1;37m|╯└─│╰ ││ ╯└─└─�[;30;42mG [1;37m �[;30;42m�[1;37m �[;30;42m�[1;37m �[;30;42ms [1;37m �[;30;42mO [1;37;40m┐ [;30;41m�[1;31;40m�[;30;40mNAYURI [m
[1m￣￣￣￣￣￣￣￣￣￣￣￣￣￣￣￣￣￣￣￣￣￣￣￣￣￣￣￣ [;30;41m�[1;31;40m�[m
[;32m◆ From: WillJor從allan.cs.nthu.edu.tw [m
ぃ熬み~
Oct 31, 2013, 3:52:16 AM10/31/13
to
清華大學資訊工程學系博士學位口試
學生姓名： 王翔昱
指導教授： 唐傳義 老師
指導委員：
口試委員： 韓永楷 老師、盧錦隆 老師、林俊淵 老師、葉信宏 老師
日期時間： 民國 102 年 11 月 07 日 13 時 30 分
口試地點： 清華大學台達館 629 會議室
口試題目： Application of Motif-Based Tools on Evolutionary Analysis of
Multipartite Single-Stranded DNA Viruses
相似短序列比對工具於多組分單鏈去氧核糖核酸病毒演化分析之應用
論文摘要：
Multipartite viruses contain more than one distinctive genome component,
and the origin of multipartite viruses has been suggested to evolve from
a non-segmented wild-type virus. To explore whether recombination also
plays a role in the evolution of the genomes of multipartite viruses,
we developed a systematic approach that employs motif-finding tools to
detect conserved motifs from divergent genomic regions and applies statistical
approaches to select high-confidence motifs. The information that this approach
provides helps us understand the evolution of viruses. In this study, we
compared our motif-based strategy with current alignment-based
recombination-detecting methods and applied our methods to the analysis of
multipartite single-stranded plant DNA viruses, including bipartite
begomoviruses, Banana bunchy top virus (BBTV)(consisting of 6 genome components)
學生姓名： 王翔昱
指導教授： 唐傳義 老師
指導委員：
口試委員： 韓永楷 老師、盧錦隆 老師、林俊淵 老師、葉信宏 老師
日期時間： 民國 102 年 11 月 07 日 13 時 30 分
口試地點： 清華大學台達館 629 會議室
口試題目： Application of Motif-Based Tools on Evolutionary Analysis of
Multipartite Single-Stranded DNA Viruses
相似短序列比對工具於多組分單鏈去氧核糖核酸病毒演化分析之應用
論文摘要：
Multipartite viruses contain more than one distinctive genome component,
and the origin of multipartite viruses has been suggested to evolve from
a non-segmented wild-type virus. To explore whether recombination also
plays a role in the evolution of the genomes of multipartite viruses,
we developed a systematic approach that employs motif-finding tools to
detect conserved motifs from divergent genomic regions and applies statistical
approaches to select high-confidence motifs. The information that this approach
provides helps us understand the evolution of viruses. In this study, we
compared our motif-based strategy with current alignment-based
recombination-detecting methods and applied our methods to the analysis of
multipartite single-stranded plant DNA viruses, including bipartite
and Faba bean necrotic yellows virus (FBNYV)(consisting of 8 genome components).
Our analysis revealed that recombination occurred between genome components in
some begomoviruses, BBTV and FBNYV. Our data also show that several unusual
recombination events have contributed to the evolution of BBTV genome
components. We believe that similar approaches can be applied to resolve the
evolutionary history of other viruses.
主要著作：
1.Hsiang-Iu Wang, Chih-Hung Chang, Po-Heng Lin, Hui-Chuan Fu, Chuanyi Tang
and Hsin-Hung Yeh,
“Application of Motif-based tools on evolutionary analysis of multipartite
single-stranded DNA viruses”
PLoS one 2013, DOI 10.1371/journal.pone.0071565
2.Chih-Hung Chang, Hsiang-Iu Wang, Hsiang-Chia Lu, Cheng-En Chen, Hong-Hwa Chen,
Hsin-Hung Yeh and Chuan Yi Tang,
“An efficient RNA interference screening strategy for gene functional analysis”
some begomoviruses, BBTV and FBNYV. Our data also show that several unusual
recombination events have contributed to the evolution of BBTV genome
components. We believe that similar approaches can be applied to resolve the
evolutionary history of other viruses.
主要著作：
1.Hsiang-Iu Wang, Chih-Hung Chang, Po-Heng Lin, Hui-Chuan Fu, Chuanyi Tang
and Hsin-Hung Yeh,
“Application of Motif-based tools on evolutionary analysis of multipartite
single-stranded DNA viruses”
PLoS one 2013, DOI 10.1371/journal.pone.0071565
2.Chih-Hung Chang, Hsiang-Iu Wang, Hsiang-Chia Lu, Cheng-En Chen, Hong-Hwa Chen,
Hsin-Hung Yeh and Chuan Yi Tang,
BMC Genomics 2012, 13:491 doi:10.1186/1471-2164-13-491
3.Chen, C.E., Yeh, K.C., Wu, S.H., Wang, H.I. and Yeh, H.H.
“A vicilin-like seed storage protein, PAP85, is involved in Tobacco mosaic
virus replication"
J. Virol. 2013 published ahead of print JVI00268-13R1.
4.Lu, H.C., Hsieh, M.H., Chen, C.E., Chen, H.H., Wang, H.I. and Yeh, H.H.
“A high-throughput virus-induced gene-silencing vector for screening
transcription factors in virus-induced plant defense response in orchid.”
Molecular Plant-Microbe Interactions 2012 25(6):738-746.
5.Lu, H.C.*, Chen, C.E.*, Tsai, M.H., Wang, H.I., Su, H.J. and Yeh, H.H.
“Cymbidium mosaic potexvirus isolate-dependent host movement systems reveal
two movement control determinants and the coat protein is the dominant”
Virology 2009 388, 147-159.
--
[;32m※ Origin: 楓橋驛站<bbs.cs.nthu.edu.tw>
3.Chen, C.E., Yeh, K.C., Wu, S.H., Wang, H.I. and Yeh, H.H.
“A vicilin-like seed storage protein, PAP85, is involved in Tobacco mosaic
virus replication"
J. Virol. 2013 published ahead of print JVI00268-13R1.
4.Lu, H.C., Hsieh, M.H., Chen, C.E., Chen, H.H., Wang, H.I. and Yeh, H.H.
“A high-throughput virus-induced gene-silencing vector for screening
transcription factors in virus-induced plant defense response in orchid.”
Molecular Plant-Microbe Interactions 2012 25(6):738-746.
5.Lu, H.C.*, Chen, C.E.*, Tsai, M.H., Wang, H.I., Su, H.J. and Yeh, H.H.
“Cymbidium mosaic potexvirus isolate-dependent host movement systems reveal
two movement control determinants and the coat protein is the dominant”
Virology 2009 388, 147-159.
--
[;32m◆ From: WillJor @ allan.cs.nthu.edu.tw [m
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