No, currently there is a 1:1 relationship between connections and the topic/channel that connection is subscribed to. This is fairly intentional to avoid implementation complexity.
If you find yourself wanting to subscribe to a large number of topics at the same time, often it's a useful signal that you might be better off consolidating your topics and pushing the more granular description into the messages themselves. For example, at Bitly we have several general data streams that contain a wide variety of messages, but each message has a well structured "action" key in it. Some consumers might need a few of the actions, but some need them all. By consolidating and pivoting on the messages themselves we avoid managing hundreds of discreet topics for each specific event.